{"id":"dehydrocholic-acid","rwe":[],"tags":[{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"},{"label":"Constipation","category":"indication"},{"label":"Disorder of biliary tract","category":"indication"},{"label":"Incomplete passage of stool","category":"indication"},{"label":"Cholagogues and Choleretics","category":"pharmacology"},{"label":"Gastrointestinal Agents","category":"pharmacology"}],"phase":"phase_2","safety":{"contraindications":["Appendicitis","Gastrointestinal obstruction","Incontinence of feces"]},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"decholin","offLabel":[],"synonyms":["dehydrocholic acid","cholepatin","decholin","dehystolin","ketocholanic acid","oxycholin"],"timeline":[],"approvals":[],"brandName":"Decholin","ecosystem":[{"indication":"Constipation","otherDrugs":[{"name":"bisacodyl","slug":"bisacodyl","company":"Braintree"},{"name":"cholic acid","slug":"cholic-acid","company":"Rtrx"},{"name":"docusate sodium","slug":"docusate-sodium","company":""},{"name":"glycerol","slug":"glycerol","company":"B Braun"}],"globalPrevalence":null},{"indication":"Disorder of biliary tract","otherDrugs":[{"name":"cholic acid","slug":"cholic-acid","company":"Rtrx"},{"name":"homatropine","slug":"homatropine","company":""}],"globalPrevalence":null},{"indication":"Incomplete passage of stool","otherDrugs":[{"name":"bisacodyl","slug":"bisacodyl","company":"Braintree"},{"name":"cholic acid","slug":"cholic-acid","company":"Rtrx"},{"name":"homatropine","slug":"homatropine","company":""},{"name":"macrogol","slug":"macrogol","company":"Braintree"}],"globalPrevalence":null}],"mechanism":{"modality":"Small Molecule","explanation":"Imagine your gallbladder as a water balloon that stores bile, a digestive fluid. Decholin helps to squeeze the balloon, releasing bile into the digestive system to aid in fat digestion and prevent constipation.","oneSentence":"Decholin works by stimulating the contraction of the gallbladder and increasing bile flow.","technicalDetail":"Decholin acts as a cholagogue, increasing the contraction of the gallbladder and promoting the release of bile into the bile ducts, which helps to facilitate the digestion and absorption of fats and fat-soluble vitamins."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/794","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=DEHYDROCHOLIC ACID","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T10:27:03.461982","_validation":{"fieldsValidated":1,"lastValidatedAt":"2026-04-20T08:48:55.526119+00:00","fieldsConflicting":0,"overallConfidence":0.95},"biosimilars":[],"competitors":[],"genericName":"dehydrocholic acid","indications":{"approved":[{"name":"Constipation","source":"DrugCentral","snomedId":14760008,"regulator":"FDA"},{"name":"Disorder of biliary tract","source":"DrugCentral","snomedId":105997008,"regulator":"FDA"},{"name":"Incomplete passage of stool","source":"DrugCentral","snomedId":249515001,"regulator":"FDA"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NUI":"N0000146752","MMSL":"4540","NDDF":"001203","UNII":"NH5000009I","VUID":"4018426","CHEBI":"CHEBI:31459","VANDF":"4018426","INN_ID":"157","RXNORM":"216396","UMLSCUI":"C0011182","ChEMBL_ID":"CHEMBL514446","KEGG_DRUG":"D01693","DRUGBANK_ID":"DB11622","PUBCHEM_CID":"6674","SNOMEDCT_US":"387285003","MESH_DESCRIPTOR_UI":"D003685"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":204,"therapeuticAreas":["Urology"],"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Decholin, also known as Dehydrocholic acid, is a small molecule drug with unknown drug class and target. It is used to treat constipation, disorders of the biliary tract, and incomplete passage of stool. The commercial status of Decholin is unknown, but it is likely to be off-patent. Decholin's safety considerations are not well-documented, but it is essential to monitor patients for potential side effects. Further research is needed to fully understand Decholin's pharmacology and clinical applications.","enrichmentLevel":5,"visitCount":0,"regulatoryByCountry":[{"country_code":"CA","regulator":"Health Canada","status":"approved","approval_date":null,"mah":"","brand_name_local":"","application_number":""}],"trialStats":{"total":0,"withResults":0},"validation":{"fieldsValidated":1,"lastValidatedAt":"2026-04-20T08:48:55.526119+00:00","fieldsConflicting":0,"overallConfidence":0.95},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":false,"score":2}}