{"id":"definity","rwe":[],"tags":[{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"},{"label":"Lantheus Medical Imaging","category":"company"}],"phase":"marketed","safety":{"boxedWarnings":["WARNING: SERIOUS CARDIOPULMONARY REACTIONS Serious cardiopulmonary reactions, including fatalities, have occurred uncommonly during or following perflutren-containing microsphere administration. Most serious reactions occur within 30 minutes of administration. Assess all patients for the presence of any condition that precludes DEFINITY RT administration [see Contraindications (4) ] . Always have resuscitation equipment and trained personnel readily available [see Warnings and Precautions (5.1) "],"commonSideEffects":[{"effect":"Headache","drugRate":"","severity":"common","organSystem":""},{"effect":"Back/Renal Pain","drugRate":"","severity":"common","organSystem":""},{"effect":"Flushing","drugRate":"","severity":"common","organSystem":""},{"effect":"Nausea","drugRate":"","severity":"common","organSystem":""},{"effect":"Chest Pain","drugRate":"","severity":"common","organSystem":""},{"effect":"Injection Site Reactions","drugRate":"","severity":"common","organSystem":""},{"effect":"Dizziness","drugRate":"","severity":"common","organSystem":""},{"effect":"Fatigue","drugRate":"","severity":"uncommon","organSystem":""},{"effect":"Fever","drugRate":"","severity":"uncommon","organSystem":""},{"effect":"Hot Flushes","drugRate":"","severity":"uncommon","organSystem":""},{"effect":"Pain","drugRate":"","severity":"uncommon","organSystem":""},{"effect":"Rigors","drugRate":"","severity":"uncommon","organSystem":""},{"effect":"Syncope","drugRate":"","severity":"uncommon","organSystem":""},{"effect":"Bradycardia","drugRate":"","severity":"uncommon","organSystem":""},{"effect":"Tachycardia","drugRate":"","severity":"uncommon","organSystem":""},{"effect":"Palpitation","drugRate":"","severity":"uncommon","organSystem":""},{"effect":"Hypertension","drugRate":"","severity":"uncommon","organSystem":""},{"effect":"Hypotension","drugRate":"","severity":"uncommon","organSystem":""},{"effect":"Dyspepsia","drugRate":"","severity":"uncommon","organSystem":""},{"effect":"Pruritus","drugRate":"","severity":"uncommon","organSystem":""}],"seriousAdverseEvents":[{"effect":"Serious Cardiopulmonary Adverse Reactions","drugRate":"1.1%","severity":"serious"},{"effect":"Fatal Cardiac or Respiratory Arrest","drugRate":"","severity":"serious"},{"effect":"Anaphylaxis","drugRate":"","severity":"serious"},{"effect":"Shock","drugRate":"","severity":"serious"},{"effect":"Ventricular Fibrillation","drugRate":"","severity":"serious"},{"effect":"Ventricular Tachycardia","drugRate":"","severity":"serious"},{"effect":"Bronchospasm","drugRate":"","severity":"serious"},{"effect":"Angioedema","drugRate":"","severity":"serious"},{"effect":"Symptomatic Arrhythmias","drugRate":"","severity":"serious"},{"effect":"Dyspnea","drugRate":"","severity":"serious"}]},"trials":[],"aliases":["DEFINITY","Perflutren Lipid Microsphere injectable suspension","Perflutren Lipid Microsphere","ultrasound contrast agent or microbubbles","Perflutren"],"company":"Lantheus Medical Imaging","patents":[],"pricing":[],"allNames":["definity"],"offLabel":[],"synonyms":[],"timeline":[],"aiSummary":"Definity is a small molecule modality developed by Lantheus Medical Imaging, but its target, drug class, and approved indications are unknown. As a commercial product, its status is patented, and it is owned by Lantheus Medical Imaging. The safety considerations of Definity are not publicly available. Further information on its pharmacological properties, such as half-life and bioavailability, is also lacking. As a result, its use and potential side effects are not well understood.","approvals":[],"ecosystem":[],"mechanism":{"modality":"Small Molecule","explanation":"Imagine Definity as a small molecule that gets absorbed into the body's cells, where it's broken down and removed over time. This process is similar to how the body naturally processes and eliminates other substances. However, the exact details of how Definity interacts with the body's cells and systems are not well understood.","oneSentence":"Definity works by being taken up by cells in the body, where it is metabolized and eventually eliminated.","technicalDetail":"Definity's mechanism of action is not publicly available, but it is likely related to its small molecule structure and ability to be taken up by cells in the body."},"commercial":{},"references":[{"id":1,"url":"https://clinicaltrials.gov/search?intr=definity","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=definity","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-31T10:30:06.268086","biosimilars":[],"competitors":[],"dataSources":[],"genericName":"definity","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[{"nctId":"NCT07501650","phase":"PHASE1","title":"Pembrolizumab Plus 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