{"id":"deferiprone-dose-level-2","safety":{"commonSideEffects":[{"rate":"30-40%","effect":"Gastrointestinal disturbances"},{"rate":"10-20%","effect":"Hepatotoxicity"},{"rate":"5-10%","effect":"Leukopenia"}]},"_chembl":{"chemblId":"CHEMBL70927","moleculeType":"Small molecule","molecularWeight":"139.15"},"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Deferiprone works by chelating iron, thereby reducing iron accumulation in the body.","oneSentence":"Iron chelator","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T03:31:50.641Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Beta-thalassemia major"},{"name":"Sickle cell disease"}]},"trialDetails":[{"nctId":"NCT07292259","phase":"PHASE2","title":"Combination of Thalidomide and Hydroxyuria in Transfusion Dependent Thalasemmia","status":"RECRUITING","sponsor":"Pakistan Blood and Marrow Transplant (PBMT) Group","startDate":"2024-01-01","conditions":"Transfusion Dependent Beta Thalassemia","enrollment":150},{"nctId":"NCT06509581","phase":"NA","title":"Vitamin E Supplementation for Children With Transfusion Dependent Beta Thalassemia on Different Iron Chelation Regimen","status":"COMPLETED","sponsor":"Ain Shams University","startDate":"2021-07-05","conditions":"Beta-Thalassemia","enrollment":180},{"nctId":"NCT06006091","phase":"NA","title":"The Effectiveness of the Letrozole-induced Endometrial Preparation Protocol in Frozen-thawed Embryo Transfer (FET)","status":"RECRUITING","sponsor":"International Peace Maternity and Child Health Hospital","startDate":"2023-08-01","conditions":"Letrozole, Infertility, Female","enrollment":858},{"nctId":"NCT01740713","phase":"PHASE2","title":"Pharmacokinetic Study of Deferiprone in Paediatric Patients","status":"COMPLETED","sponsor":"Consorzio per Valutazioni Biologiche e Farmacologiche","startDate":"2012-12","conditions":"Chronic Iron Overload","enrollment":23},{"nctId":"NCT02980458","phase":"PHASE1","title":"Characterisation of Relative Bioavailability With Bioequivalence Assessment of Deferiprone Tablets After Oral Single Dose Administration","status":"COMPLETED","sponsor":"SocraTec R&D GmbH","startDate":"2016-08","conditions":"Bioequivalence","enrollment":25},{"nctId":"NCT02456558","phase":"PHASE1","title":"Evaluation of the Safety, Efficacy, and Pharmacokinetics of Intravenous Deferiprone in HIV-Positive Subjects","status":"COMPLETED","sponsor":"ApoPharma","startDate":"2015-06","conditions":"Asymptomatic HIV Infection","enrollment":30},{"nctId":"NCT02173951","phase":"PHASE2, PHASE3","title":"An Algorithm to Start Iron Chelation in Minimally Transfused Young Beta-thalassemia Major Patients","status":"UNKNOWN","sponsor":"Ain Shams University","startDate":"2014-07","conditions":"Beta Thalassemia Major","enrollment":64},{"nctId":"NCT01996683","phase":"NA","title":"Efficacy and Safety of Efficacy and Safety of Continued Iron Chelation Therapy In Poly-transfused Thalassemia Patients With Low Serum Ferritin (< 500 ng/ml)","status":"UNKNOWN","sponsor":"Ain Shams University","startDate":"2014-11","conditions":"Beta-thalassemia, Serum Ferritin, Iron Chelation Therapy","enrollment":50},{"nctId":"NCT01989455","phase":"PHASE1","title":"A Blinded, Placebo-Controlled Study of the Safety and Pharmacokinetics of Single Doses of Intravenous Deferiprone in Healthy Volunteers","status":"COMPLETED","sponsor":"ApoPharma","startDate":"2013-11","conditions":"Healthy Volunteers","enrollment":64},{"nctId":"NCT01860703","phase":"PHASE4","title":"Evaluation of Whether Deferiprone Affects QT Interval in Healthy Subjects","status":"COMPLETED","sponsor":"ApoPharma","startDate":"2012-11","conditions":"Prolonged QTc Interval","enrollment":50},{"nctId":"NCT01770652","phase":"PHASE4","title":"An Open-label, Non-randomized, Parallel Group Study in Subjects With Mild, Moderate, Severe, or No Renal Impairment","status":"COMPLETED","sponsor":"ApoPharma","startDate":"2013-01","conditions":"Renal Impairment","enrollment":32},{"nctId":"NCT02191657","phase":"PHASE1","title":"Antiretroviral Activity and Pharmacokinetics of Deferiprone in Healthy Volunteers and Asymptomatic HIV-infected Subjects","status":"COMPLETED","sponsor":"ApoPharma","startDate":"2006-11","conditions":"HIV Infection","enrollment":26},{"nctId":"NCT00943748","phase":"PHASE2, PHASE3","title":"Efficacy and Safety of the Iron Chelator Deferiprone in Parkinson's Disease","status":"COMPLETED","sponsor":"University Hospital, Lille","startDate":"2009-10","conditions":"Parkinson's Disease","enrollment":40},{"nctId":"NCT01511848","phase":"PHASE2, PHASE3","title":"Study Of Efficacy,Safety of Combined Deferasirox and Deferiprone Versus Combined Deferiprone and Desferal In Conditions of Iron Overload","status":"UNKNOWN","sponsor":"Ain Shams University","startDate":"2012-02","conditions":"Beta-thalassemia Major, Sickle Cell Disease, Iron Hemosiderosis","enrollment":60},{"nctId":"NCT00897221","phase":"PHASE2","title":"A Study Investigating the Long-term Safety and Efficacy of Deferiprone in Patients With Friedreich's Ataxia","status":"COMPLETED","sponsor":"ApoPharma","startDate":"2009-06","conditions":"Friedreich's Ataxia","enrollment":36}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["DFP"],"phase":"phase_2","status":"active","brandName":"Deferiprone, dose level 2","genericName":"Deferiprone, dose level 2","companyName":"Consorzio per Valutazioni Biologiche e Farmacologiche","companyId":"consorzio-per-valutazioni-biologiche-e-farmacologiche","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Iron chelator Used for Beta-thalassemia major, Sickle cell disease.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}