{"id":"deep-frozen-platelets","safety":{"commonSideEffects":[{"rate":null,"effect":"Transfusion reaction (febrile, allergic)"},{"rate":null,"effect":"Alloimmunization"},{"rate":null,"effect":"Transfusion-related acute lung injury (TRALI)"},{"rate":null,"effect":"Bacterial contamination / sepsis"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Platelets are isolated from donor blood, treated with cryoprotectants (typically DMSO), and frozen at ultra-low temperatures to preserve viability. Upon thawing and transfusion, these platelets restore platelet count and function to prevent or treat bleeding complications. This approach extends platelet shelf-life beyond the standard 5-day room-temperature storage, enabling better inventory management and availability.","oneSentence":"Deep-frozen platelets are cryopreserved blood platelets that are thawed and transfused to restore hemostatic function in patients with thrombocytopenia or platelet dysfunction.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:08:56.151Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Thrombocytopenia requiring platelet transfusion support"},{"name":"Platelet refractoriness in hematologic and oncologic patients"}]},"trialDetails":[{"nctId":"NCT05502809","phase":"PHASE3","title":"Frozen Platelets in the Treatmentof Traumatic or Vascular Bleeding","status":"UNKNOWN","sponsor":"Alrijne Ziekenhuis Leiderdorp","startDate":"2023-06-01","conditions":"Trauma, Bleeding","enrollment":158}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":4,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Cryopreserved platelets"],"phase":"phase_3","status":"active","brandName":"Deep-frozen platelets","genericName":"Deep-frozen platelets","companyName":"Alrijne Ziekenhuis Leiderdorp","companyId":"alrijne-ziekenhuis-leiderdorp","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Deep-frozen platelets are being studied as a potential treatment for trauma and bleeding conditions. The exact mechanism of action of deep-frozen platelets is currently unknown.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}