{"id":"decamethrin","rwe":[{"pmid":"29184267","year":"2017","title":"Deltamethrin-Induced Hepatotoxicity and Virgin Olive Oil Consumption: An Experimental Study.","finding":"","journal":"Iranian journal of medical sciences","studyType":"Clinical Study"},{"pmid":"21947500","year":"2011","title":"Persistence of cypermethrin and decamethrin residues in/on brinjal fruits.","finding":"","journal":"Bulletin of environmental contamination and toxicology","studyType":"Clinical Study"},{"pmid":"18598261","year":"2008","title":"Neurokinin 2 receptor-mediated activation of protein kinase C modulates capsaicin responses in DRG neurons from adult rats.","finding":"","journal":"The European journal of neuroscience","studyType":"Clinical Study"},{"pmid":"16770503","year":"2006","title":"Facile and sensitive spectrophotometric determination of synthetic pyrithroids in their formulations, water and grain samples.","finding":"","journal":"Environmental monitoring and assessment","studyType":"Clinical Study"},{"pmid":"11222940","year":"2001","title":"Glutathione S-transferase in the defence against pyrethroids in insects.","finding":"","journal":"Insect biochemistry and molecular biology","studyType":"Clinical Study"}],"tags":[{"label":"decamethrin","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"P03BA03","category":"atc"},{"label":"Active","category":"status"},{"label":"Insecticides","category":"pharmacology"},{"label":"Pesticides","category":"pharmacology"}],"phase":"unknown","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"decistab","offLabel":[],"synonyms":["NRDC 161","decamethrin","decistab","deltamethrin","decamethrine"],"timeline":[],"approvals":[],"brandName":"Decistab","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"decamethrin","explanation":"Imagine your nerves are like a highway system, and sodium ions are like cars driving on that highway. Decamethrin blocks the sodium ions from driving, causing a traffic jam that prevents the nerve cells from functioning properly, leading to paralysis and death.","oneSentence":"Decamethrin works by binding to the insect's voltage-gated sodium channels, preventing the normal flow of sodium ions and disrupting the nervous system.","technicalDetail":"Decamethrin binds to the insect's voltage-gated sodium channels, specifically the alpha subunit, and prevents the normal flow of sodium ions, leading to a prolonged depolarization of the nerve cell membrane and eventual cell death."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/4378","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=decamethrin","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=decamethrin","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T10:30:20.115570","biosimilars":[],"competitors":[],"genericName":"decamethrin","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[{"nctId":"NCT07004257","phase":"NA","title":"ButOx Human Trial: An Open Label Prospective Cohort Study to Investigate the Effect of Tributyrin (Butyrate Precursor Molecule) Supplementation on Markers of Calcium Oxalate Nephrolithiasis","status":"NOT_YET_RECRUITING","sponsor":"University of British Columbia","startDate":"2025-07-01","conditions":["Urolithiasis"],"enrollment":10,"completionDate":"2028-07-01"},{"nctId":"NCT05736679","phase":"NA","title":"EaveTubes for Vector Control","status":"ACTIVE_NOT_RECRUITING","sponsor":"University of Notre Dame","startDate":"2023-03-23","conditions":["Malaria"],"enrollment":1870,"completionDate":"2025-12"},{"nctId":"NCT04566510","phase":"NA","title":"LLIN Evaluation in Uganda Project","status":"COMPLETED","sponsor":"University of California, San Francisco","startDate":"2020-10-17","conditions":["Malaria"],"enrollment":32895,"completionDate":"2023-03-31"},{"nctId":"NCT04230161","phase":"","title":"Estimating the Malaria Prevention Impact of New Nets: Observational Analyses to Evaluate the Evidence Generated During Piloted New Net Distributions in Rwanda","status":"COMPLETED","sponsor":"PATH","startDate":"2020-02-24","conditions":["Malaria"],"enrollment":3502,"completionDate":"2022-11-18"},{"nctId":"NCT04157894","phase":"","title":"Estimating the Malaria Prevention Impact of New Nets: Observational Analyses to Evaluate the Evidence Generated During Piloted New Net Distributions in Burkina Faso","status":"COMPLETED","sponsor":"PATH","startDate":"2019-07-07","conditions":["Malaria"],"enrollment":5606,"completionDate":"2022-07-06"},{"nctId":"NCT05125133","phase":"NA","title":"Evaluation of Insecticide-treated Eave Nets and Window Screens for Malaria Control in Tanzania.","status":"UNKNOWN","sponsor":"Ifakara Health Institute","startDate":"2021-07-09","conditions":["Malaria,Falciparum"],"enrollment":1800,"completionDate":"2022-09-30"},{"nctId":"NCT03269006","phase":"NA","title":"Improved Case Detection and Vector Control for Visceral Leishmaniasis","status":"COMPLETED","sponsor":"International Centre for Diarrhoeal Disease Research, Bangladesh","startDate":"2016-01-01","conditions":["Visceral Leishmaniasis"],"enrollment":202,"completionDate":"2019-07-30"},{"nctId":"NCT01644682","phase":"PHASE3","title":"Replacement of Insecticides to Control Visceral Leishmaniasis (VL)","status":"COMPLETED","sponsor":"International Centre for Diarrhoeal Disease Research, Bangladesh","startDate":"2012-05","conditions":["Cost-effective and Sustainable Vector Control Methods Will be Established to Reduce VL in India, Bangladesh and Nepal"],"enrollment":3600,"completionDate":"2014-12"},{"nctId":"NCT02458066","phase":"NA","title":"Trial to Compare Effectiveness of 2 Insecticides in Preventing Malaria","status":"COMPLETED","sponsor":"Medical Care Development, Inc.","startDate":"2014-02","conditions":["Malaria"],"enrollment":2800,"completionDate":"2014-10"},{"nctId":"NCT01575613","phase":"NA","title":"Reducing the Burden of Malaria by Targeting Hotspots of Malaria Transmission","status":"COMPLETED","sponsor":"Radboud University Medical Center","startDate":"2012-04","conditions":["Malaria"],"enrollment":17506,"completionDate":"2012-11"},{"nctId":"NCT01713517","phase":"PHASE4","title":"Impact of Insecticide Resistance on Vector Control","status":"UNKNOWN","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2011-04","conditions":["Malaria, Falciparum"],"enrollment":28000,"completionDate":"2014-10"},{"nctId":"NCT01456858","phase":"PHASE3","title":"Insecticide Treated Polyethylene Sheeting for Prevention of Malaria in Emergencies","status":"COMPLETED","sponsor":"The Mentor Initiative","startDate":"2003-12","conditions":["Malaria"],"enrollment":222,"completionDate":"2004-07"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"004346","UNII":"2JTS8R821G","CHEBI":"CHEBI:4388","RXNORM":"22374","UMLSCUI":"C0057233","ChEMBL_ID":"CHEMBL1593566","KEGG_DRUG":"D07785","DRUGBANK_ID":"DB13600","PUBCHEM_CID":"40585","MESH_SUPPLEMENTAL_RECORD_UI":"C017180"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":48,"therapeuticAreas":["Other"],"atcClassification":{"source":"DrugCentral","atcCode":"P03BA03","allCodes":["P03BA03"]},"biosimilarFilings":[],"recentPublications":[{"date":"2017 Nov","pmid":"29184267","title":"Deltamethrin-Induced Hepatotoxicity and Virgin Olive Oil Consumption: An Experimental Study.","journal":"Iranian journal of medical sciences"},{"date":"2011 Dec","pmid":"21947500","title":"Persistence of cypermethrin and decamethrin residues in/on brinjal fruits.","journal":"Bulletin of environmental contamination and toxicology"},{"date":"2008 Jun","pmid":"18598261","title":"Neurokinin 2 receptor-mediated activation of protein kinase C modulates capsaicin responses in DRG neurons from adult rats.","journal":"The European journal of neuroscience"},{"date":"2006 Nov","pmid":"16770503","title":"Facile and sensitive spectrophotometric determination of synthetic pyrithroids in their formulations, water and grain samples.","journal":"Environmental monitoring and assessment"},{"date":"2001 Mar 15","pmid":"11222940","title":"Glutathione S-transferase in the defence against pyrethroids in insects.","journal":"Insect biochemistry and molecular biology"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Decistab is a small molecule insecticide. It is used in the manufacture of long-lasting insecticidal mosquito nets to control malaria vectors.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":true,"score":2}}