{"id":"de-130a","safety":{"commonSideEffects":[]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"DE-130A targets specific pathways involved in aqueous humor dynamics and ocular inflammation. The drug is being developed for ophthalmic conditions where reduction of intraocular pressure and anti-inflammatory effects are therapeutically beneficial.","oneSentence":"DE-130A is a small-molecule inhibitor designed to modulate intraocular pressure and inflammation in the eye.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T01:08:53.086Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Glaucoma or ocular hypertension (Phase 3 indication)"}]},"trialDetails":[{"nctId":"NCT04133311","phase":"PHASE3","title":"A Phase III Multinational Multicenter Investigator-Masked Randomized Active-Controlled Trial Comparing the Efficacy and Safety of DE-130A With Xalatan® in Patients With Open-Angle Glaucoma or Ocular Hypertension","status":"COMPLETED","sponsor":"Santen SAS","startDate":"2019-04-10","conditions":"Open-Angle Glaucoma or Ocular Hypertension, Ocular Surface Disease","enrollment":386}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Catiolanze®"],"phase":"phase_3","status":"active","brandName":"DE-130A","genericName":"DE-130A","companyName":"Santen SAS","companyId":"santen-sas","modality":"Small molecule","firstApprovalDate":"","aiSummary":"DE-130A is a small-molecule inhibitor designed to modulate intraocular pressure and inflammation in the eye. Used for Glaucoma or ocular hypertension (Phase 3 indication).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":true,"score":3}}