{"id":"de-127-ophthalmic-solution-high-dose","_chembl":null,"modality":"Small molecule","_dailymed":null,"_scrapedAt":"2026-03-28T03:10:04.546Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"_claudeStub":{"ts":1779123820,"model":"claude-sonnet-4-5-20250929"},"description":"DE-127 Ophthalmic Solution high dose is an investigational eye drop formulation being developed by Santen Pharmaceutical for ophthalmic conditions. Currently in Phase 2 clinical trials, the drug's specific molecular target and mechanism of action have not been publicly disclosed.","indications":{"approved":[{"status":"investigational","condition":"Ophthalmic condition (unspecified)","patientPopulation":"Adult"}]},"trialDetails":[{"nctId":"NCT03329638","phase":"PHASE2","title":"A Study Assessing the Efficacy and Safety of DE-127 Ophthalmic Solution in Subjects With Mild or Moderate Myopia (APPLE)","status":"COMPLETED","sponsor":"Santen Pharmaceutical Co., Ltd.","startDate":"2017-10-27","conditions":"Myopia","enrollment":99}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_2","status":"active","brandName":"DE-127 Ophthalmic Solution high dose","genericName":"DE-127 Ophthalmic Solution high dose","companyName":"Santen Pharmaceutical Co., Ltd.","companyId":"santen-pharmaceutical-co-ltd","firstApprovalDate":"","aiSummary":"DE-127 Ophthalmic Solution is being studied for its efficacy and safety in treating mild or moderate myopia. According to ClinicalTrials.gov, DE-127 Ophthalmic Solution is being tested in various doses, including high dose, for this condition.","enrichmentLevel":2,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":false,"indications":true,"safety":false,"trials":true,"score":2}}