{"id":"de-117b-eye-drops","safety":{"commonSideEffects":[{"rate":null,"effect":"Conjunctival hyperemia"},{"rate":null,"effect":"Eye irritation"},{"rate":null,"effect":"Instillation site discomfort"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"ROCK inhibitors modulate the cytoskeleton and cell contractility in ocular tissues, particularly enhancing conventional outflow facility in the eye's drainage system. By inhibiting ROCK signaling, DE-117B increases the ease with which fluid drains from the anterior chamber, thereby lowering intraocular pressure. This mechanism differs from prostaglandin analogs and beta-blockers, offering a novel approach to glaucoma management.","oneSentence":"DE-117B is a selective rho kinase (ROCK) inhibitor that reduces intraocular pressure by improving aqueous humor outflow through the trabecular meshwork and Schlemm's canal.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:08:50.261Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Glaucoma or ocular hypertension"}]},"trialDetails":[{"nctId":"NCT06666855","phase":"PHASE3","title":"A Phase III Study in Subjects With Primary Open Angle Glaucoma or Ocular Hypertension in China","status":"RECRUITING","sponsor":"Santen Pharmaceutical Co., Ltd.","startDate":"2024-11-28","conditions":"Open Angle Glaucoma, Ocular Hypertension","enrollment":338}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"DE-117B Eye Drops","genericName":"DE-117B Eye Drops","companyName":"Santen Pharmaceutical Co., Ltd.","companyId":"santen-pharmaceutical-co-ltd","modality":"Small molecule","firstApprovalDate":"","aiSummary":"DE-117B is a selective rho kinase (ROCK) inhibitor that reduces intraocular pressure by improving aqueous humor outflow through the trabecular meshwork and Schlemm's canal. Used for Glaucoma or ocular hypertension.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}