{"id":"de-104-high-concentration","_chembl":null,"_dailymed":null,"_scrapedAt":"2026-03-28T05:01:36.931Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"_claudeStub":{"ts":1779123378,"model":"claude-sonnet-4-5-20250929"},"description":"DE-104 high concentration is an investigational ophthalmic agent being developed by Santen Inc. for eye disorders. Currently in Phase 1 clinical development, the drug's molecular target, mechanism of action, and specific therapeutic indications have not been publicly disclosed.","indications":{"approved":[{"status":"investigational","condition":"Ophthalmic disorder (unspecified)","patientPopulation":"Adult"}]},"trialDetails":[{"nctId":"NCT00868894","phase":"PHASE1, PHASE2","title":"Safety and Efficacy Study of DE-104 Ophthalmic Solution to Treat Open-angle Glaucoma or Ocular Hypertension","status":"COMPLETED","sponsor":"Santen Inc.","startDate":"2009-03","conditions":"Open-Angle Glaucoma, Ocular Hypertension","enrollment":49},{"nctId":"NCT00650338","phase":"PHASE2","title":"Safety and Efficacy Study of DE-104 Ophthalmic Solution to Treat Open-angle Glaucoma or Ocular Hypertension","status":"COMPLETED","sponsor":"Santen Inc.","startDate":"2008-03","conditions":"Open-Angle Glaucoma, Ocular Hypertension","enrollment":165},{"nctId":"NCT00657579","phase":"PHASE2","title":"Safety and Efficacy Study of DE-104 Ophthalmic Solution to Treat Open-Angle Glaucoma or Ocular Hypertension","status":"COMPLETED","sponsor":"Santen Pharmaceutical Co., Ltd.","startDate":"","conditions":"Open-Angle Glaucoma, Ocular Hypertension","enrollment":""}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":41314,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_1","status":"active","brandName":"DE-104 high concentration","genericName":"DE-104 high concentration","companyName":"Santen Inc.","companyId":"santen-inc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"DE-104 is an ophthalmic solution used to treat Open-Angle Glaucoma and Ocular Hypertension. It is a Rho-associated protein kinase inhibitor, classified as an inhibitor drug modality.","enrichmentLevel":2,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":false,"indications":true,"safety":false,"trials":true,"score":2}}