{"id":"darbepoetin-alfa-sf","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Injection site reaction"},{"rate":"10-20%","effect":"Headache"},{"rate":"5-10%","effect":"Fatigue"},{"rate":"5-10%","effect":"Nausea"},{"rate":"5-10%","effect":"Dizziness"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Darbepoetin alfa SF is an erythropoiesis-stimulating protein that works by binding to the erythropoietin receptor on the surface of erythroid progenitor cells, stimulating their proliferation and differentiation into mature red blood cells. This leads to an increase in red blood cell production and a subsequent increase in hemoglobin levels.","oneSentence":"Darbepoetin alfa SF stimulates erythropoiesis by binding to the erythropoietin receptor.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:08:42.120Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Treatment of anemia associated with chronic kidney disease"}]},"trialDetails":[{"nctId":"NCT00093977","phase":"PHASE3","title":"Study to Assess Darbepoetin Alfa in Subjects With Chronic Kidney Disease","status":"COMPLETED","sponsor":"Amgen","startDate":"2004-10","conditions":"Kidney Disease, Chronic Kidney Disease","enrollment":1100}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":9,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"darbepoetin alfa SF","genericName":"darbepoetin alfa SF","companyName":"Amgen","companyId":"amgen","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Darbepoetin alfa SF stimulates erythropoiesis by binding to the erythropoietin receptor. Used for Treatment of anemia associated with chronic kidney disease.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}