{"id":"dapsone-plus-tretinoin-gel","safety":{"commonSideEffects":[{"rate":null,"effect":"Erythema"},{"rate":null,"effect":"Dryness"},{"rate":null,"effect":"Peeling"},{"rate":null,"effect":"Irritation"},{"rate":null,"effect":"Photosensitivity"}]},"_chembl":{"chemblId":"CHEMBL1043","moleculeType":"Small molecule","molecularWeight":"248.31"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Dapsone is a sulfone antibiotic with anti-inflammatory properties that inhibits neutrophil function and reduces inflammatory mediators, while tretinoin is a retinoid that increases cell turnover, reduces comedone formation, and normalizes sebaceous gland function. Together, they address both the inflammatory and comedonal components of acne vulgaris and related dermatological conditions.","oneSentence":"Dapsone reduces inflammation and bacterial growth while tretinoin promotes skin cell turnover and normalizes keratinization to treat acne and related inflammatory skin conditions.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:32:03.897Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acne vulgaris"}]},"trialDetails":[{"nctId":"NCT01313728","phase":"PHASE4","title":"A Study That Evaluates the Decrease in Irritation When Using Additional Acne Treatment Products","status":"COMPLETED","sponsor":"Bausch Health Americas, Inc.","startDate":"2010-12","conditions":"Acne Vulgaris","enrollment":26}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Aczone Gel 5% plus Retin-A Micro Gel 0.1% Pump"],"phase":"marketed","status":"active","brandName":"Dapsone plus Tretinoin Gel","genericName":"Dapsone plus Tretinoin Gel","companyName":"Bausch Health Americas, Inc.","companyId":"bausch-health-americas-inc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Dapsone reduces inflammation and bacterial growth while tretinoin promotes skin cell turnover and normalizes keratinization to treat acne and related inflammatory skin conditions. Used for Acne vulgaris.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}