{"id":"dapsone-5-0-gel-seegpharm","safety":{"commonSideEffects":[{"rate":null,"effect":"Local skin irritation"},{"rate":null,"effect":"Erythema"},{"rate":null,"effect":"Dryness"},{"rate":null,"effect":"Contact dermatitis"}]},"_chembl":{"chemblId":"CHEMBL1043","moleculeType":"Small molecule","molecularWeight":"248.31"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Dapsone works through dual mechanisms: as an antimicrobial agent targeting bacterial folate synthesis, and as an immunomodulator that reduces neutrophil-mediated inflammation. In topical gel formulation, it penetrates skin to suppress inflammatory pathways relevant to acne and other dermatological conditions. The anti-inflammatory effects are particularly useful in conditions driven by neutrophil activation and oxidative stress.","oneSentence":"Dapsone is a sulfone antibiotic that inhibits bacterial dihydropteroate synthase and has anti-inflammatory properties through suppression of neutrophil function and reactive oxygen species production.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:45:42.553Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acne vulgaris (topical gel formulation)"},{"name":"Rosacea (potential indication based on anti-inflammatory properties)"}]},"trialDetails":[{"nctId":"NCT02865005","phase":"PHASE3","title":"Trial of Dapsone 5.0% Gel in the Treatment of Acne Vulgaris","status":"COMPLETED","sponsor":"Seegpharm S.A.","startDate":"2016-02","conditions":"Acne Vulgaris","enrollment":2361}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Experimental Arm"],"phase":"phase_3","status":"active","brandName":"Dapsone 5.0% Gel (SEEGPharm)","genericName":"Dapsone 5.0% Gel (SEEGPharm)","companyName":"Seegpharm S.A.","companyId":"seegpharm-s-a","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Dapsone is a sulfone antibiotic that inhibits bacterial dihydropteroate synthase and has anti-inflammatory properties through suppression of neutrophil function and reactive oxygen species production. Used for Acne vulgaris (topical gel formulation), Rosacea (potential indication based on anti-inflammatory properties).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}