{"id":"dalacin-c","safety":{"commonSideEffects":[{"rate":"10-30","effect":"Diarrhea"},{"rate":"5-10","effect":"Nausea"},{"rate":"5-10","effect":"Abdominal pain"},{"rate":"0.1-1","effect":"Pseudomembranous colitis"},{"rate":"2-5","effect":"Rash"}]},"_chembl":{"chemblId":"CHEMBL1753","moleculeType":"Small molecule","molecularWeight":"424.99"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Clindamycin is a lincosamide antibiotic that binds to the bacterial 50S ribosomal subunit and inhibits transpeptidation and translocation reactions, thereby suppressing bacterial protein synthesis. This bacteriostatic action is effective against a broad spectrum of gram-positive and anaerobic bacteria, making it useful for treating infections in oral and maxillofacial surgery where anaerobic organisms are common.","oneSentence":"Dalacin C (clindamycin) inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, preventing peptide bond formation.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:32:02.557Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Bacterial infections in oral and maxillofacial surgery"},{"name":"Anaerobic bacterial infections"},{"name":"Gram-positive bacterial infections"}]},"trialDetails":[{"nctId":"NCT05164081","phase":"PHASE3","title":"Dual vs. Single-Antibiotic Impregnated Cement in Hemiarthroplasty for Femoral Neck Fracture","status":"ACTIVE_NOT_RECRUITING","sponsor":"Umeå University","startDate":"2022-01-01","conditions":"Femoral Neck Fractures, Prosthetic Infection","enrollment":7000},{"nctId":"NCT07202091","phase":"PHASE2, PHASE3","title":"Role of Antibiotic Therapy or Immunoglobulin On iNfections in hAematoLogy Immunoglobulin Stopping or Extension (Stop Ig)","status":"RECRUITING","sponsor":"Monash University","startDate":"2025-05-06","conditions":"Myeloma, Leukemia, Non Hodgkin's Lymphoma","enrollment":900},{"nctId":"NCT07016217","phase":"NA","title":"Evaluation of an Educational Intervention on Antibiotics in Dental Care","status":"ACTIVE_NOT_RECRUITING","sponsor":"University of British Columbia","startDate":"2023-05-15","conditions":"Dental Infection, Clindamycin, Antibiotics","enrollment":3498},{"nctId":"NCT06787885","phase":"NA","title":"Evaluation of Efficacy and Safety Parameters of Different Antibiotics Regimens for Management of Empyema","status":"RECRUITING","sponsor":"Fayoum University","startDate":"2024-05-01","conditions":"Empyema, Pleural","enrollment":90},{"nctId":"NCT06702345","phase":"NA","title":"Clostridioides Difficile Controlled Human Infection Model","status":"NOT_YET_RECRUITING","sponsor":"Leiden University Medical Center","startDate":"2025-03-01","conditions":"C. Difficile, C. Difficile Infection, Controlled Human Infection","enrollment":60},{"nctId":"NCT06539299","phase":"NA","title":"Socket Preservation - A Randomized Clinical Implementation in a Student Setting","status":"NOT_YET_RECRUITING","sponsor":"Sigmund Freud PrivatUniversitat","startDate":"2024-09-01","conditions":"Alveolar Bone Loss, Dental Implant, Bone Augmentation","enrollment":51},{"nctId":"NCT06336824","phase":"PHASE3","title":"Early Intravenous to Oral Antibiotic Switch in Uncomplicated Staphylococcus Aureus Bacteraemia","status":"RECRUITING","sponsor":"Clinical Research Centre, Malaysia","startDate":"2024-06-28","conditions":"Staphylococcus Aureus Bacteremia","enrollment":290},{"nctId":"NCT05678621","phase":"PHASE2, PHASE3","title":"Role of Antibiotic Therapy or Immunoglobulin On iNfections in hAematoLogy: Immunoglobulin Stopping or Extension","status":"RECRUITING","sponsor":"Monash University","startDate":"2022-11-30","conditions":"Haematological Malignancy, Hypogammaglobulinemia","enrollment":300},{"nctId":"NCT02538991","phase":"NA","title":"TVT Versus Bulkamid®-Injections in Treatment of Stress Urinary Incontinence","status":"ACTIVE_NOT_RECRUITING","sponsor":"Helsinki University Central Hospital","startDate":"2015-09","conditions":"Urinary Stress Incontinence","enrollment":224},{"nctId":"NCT06291181","phase":"NA","title":"Studying the Distribution of Accessory Gene Regulator (Agr) Quorum Sensing System and the Prevalence of Linezolid and Mupirocin Resistance in Biofilm Producer/Non Producer Staphylococcus Aureus in Sohag University Hospitals","status":"COMPLETED","sponsor":"Sohag University","startDate":"2023-01-01","conditions":"Staphylococcus Aureus","enrollment":265},{"nctId":"NCT06158451","phase":"NA","title":"Clinical and Radiographic Evaluation of Zinc Oxide-Propolis Mixture Versus Modified Triple Antibiotic Paste in LSTR","status":"UNKNOWN","sponsor":"Cairo University","startDate":"2024-03-01","conditions":"Pain, Postoperative, Periapical; Infection","enrollment":40},{"nctId":"NCT06068673","phase":"NA","title":"The Potential Impact of Clindamycin on Neurosurgery Patients.","status":"COMPLETED","sponsor":"Damanhour University","startDate":"2023-03-01","conditions":"Neurologic Complication, Neurosurgery","enrollment":44},{"nctId":"NCT05465304","phase":"","title":"Effect of Azithromycin in Preventing Premature Labour","status":"COMPLETED","sponsor":"Beni-Suef University","startDate":"2021-10-01","conditions":"Pregnant With Complication","enrollment":200},{"nctId":"NCT01876628","phase":"PHASE4","title":"Adjunctive Clindamycin for Cellulitis: C4C Trial.","status":"COMPLETED","sponsor":"University Hospitals Bristol and Weston NHS Foundation Trust","startDate":"2013-10","conditions":"Cellulitis","enrollment":410},{"nctId":"NCT05268835","phase":"PHASE4","title":"Different Oral Doses of Clindamycin in Preventing Post-operative Sequelae of Lower Third Molar Surgery","status":"UNKNOWN","sponsor":"Oral and Maxillofacial Surgery Clinic, Poland","startDate":"2020-02-01","conditions":"Impacted Third Molar Tooth, Impacted Molar","enrollment":300},{"nctId":"NCT02099240","phase":"EARLY_PHASE1","title":"Patients Response to Early Switch To Oral:Osteomyelitis Study","status":"TERMINATED","sponsor":"Julio Ramirez","startDate":"2014-03-06","conditions":"Osteomyelitis","enrollment":11},{"nctId":"NCT03431701","phase":"NA","title":"Chlorhexidine Vaginal Cleansing Versus Iodine Prior to C-section and the Rate of Postoperative Infection","status":"COMPLETED","sponsor":"Makassed General Hospital","startDate":"2018-02-08","conditions":"Vaginal Scrubbing","enrollment":333},{"nctId":"NCT03234517","phase":"PHASE2","title":"Vaginal Clindamycin Cream Plus Vaginal Probiotic for Bacterial Vaginosis","status":"UNKNOWN","sponsor":"Zagazig University","startDate":"2016-08-01","conditions":"Bacterial Vaginosis Treatment","enrollment":200},{"nctId":"NCT02674191","phase":"NA","title":"Posterior Segment Intrusion Using Miniplates","status":"UNKNOWN","sponsor":"Manal El Namrawy","startDate":"2016-05","conditions":"Orthodontic Anchorage Procedures","enrollment":24},{"nctId":"NCT03412071","phase":"NA","title":"Effect of Antibiotics on Penile Microbiome and HIV Susceptibility Study in Ugandan Men","status":"UNKNOWN","sponsor":"University of Toronto","startDate":"2017-12-07","conditions":"Foreskin HIV Susceptibility","enrollment":125},{"nctId":"NCT01929278","phase":"PHASE1","title":"W0265-103: A Single-Center, Evaluator-Blinded, Randomized, Placebo Controlled, Phase 1 Clinical Trial Evaluating The Phototoxic Potential Of Topically Applied Clindamycin 1.0% - Tretinoin 0.025% Gel (Ct Gel) In Healthy Volunteers","status":"COMPLETED","sponsor":"Stiefel, a GSK Company","startDate":"2008-12-08","conditions":"Acne Vulgaris","enrollment":37},{"nctId":"NCT00730028","phase":"PHASE2","title":"Uncomplicated Skin and Soft Tissue Infections Caused by Community-Associated Methicillin-Resistant Staphylococcus Aureus","status":"COMPLETED","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"2009-04","conditions":"Staphylococcal Infection","enrollment":1310},{"nctId":"NCT02054676","phase":"NA","title":"Validation of the Jawbone Anatomy Classification in Endosseous Dental Implant Treatment","status":"UNKNOWN","sponsor":"Lithuanian University of Health Sciences","startDate":"2014-02","conditions":"Partially Edentulous Jaw","enrollment":80},{"nctId":"NCT02348463","phase":"","title":"Treatment of Bacterial Vaginosis in Early Pregnancy in Skaraborg and the Effect on Spontaneous Preterm Delivery","status":"COMPLETED","sponsor":"Skaraborg Hospital","startDate":"2007-01","conditions":"Bacterial Vaginosis","enrollment":540},{"nctId":"NCT01823523","phase":"NA","title":"Orthognathic Surgery and Postoperative Antibiotic Use","status":"UNKNOWN","sponsor":"Atlantic Center for Oral and Maxillofacial Surgery","startDate":"2013-06","conditions":"Dentofacial Deformity","enrollment":300},{"nctId":"NCT01245322","phase":"PHASE4","title":"Treatment of Bacterial Vaginosis Combined With Human Lactobacilli","status":"COMPLETED","sponsor":"Skaraborg Hospital","startDate":"2007-01","conditions":"Bacterial Vaginosis","enrollment":75},{"nctId":"NCT01374581","phase":"PHASE3","title":"Impact of Artemisinin-based Combination Therapy and Quinine on Treatment Failure and Resistance in Uncomplicated Malaria","status":"COMPLETED","sponsor":"Universiteit Antwerpen","startDate":"2012-05","conditions":"Malaria","enrollment":2117},{"nctId":"NCT01757236","phase":"PHASE2","title":"Efficacy and Safety Study of Antibiotic Treatment to Treat Hip Prosthetic Joint Infection","status":"UNKNOWN","sponsor":"University Hospital, Tours","startDate":"2012-10","conditions":"Hip Prosthetic Joint Infection","enrollment":100},{"nctId":"NCT00219570","phase":"PHASE4","title":"Dalacin-T Gel Post Approval Study","status":"COMPLETED","sponsor":"Pfizer","startDate":"2005-01","conditions":"Acne Vulgaris","enrollment":134},{"nctId":"NCT00997048","phase":"NA","title":"Comparison Between Laying Open and Sinus Excision of Pilonidal Sinus - a Randomized Study","status":"COMPLETED","sponsor":"Uppsala University","startDate":"2002-10","conditions":"Pilonidal Sinus","enrollment":80}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":16,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Dalacin C","genericName":"Dalacin C","companyName":"Oral and Maxillofacial Surgery Clinic, Poland","companyId":"oral-and-maxillofacial-surgery-clinic-poland","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Dalacin C (clindamycin) inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, preventing peptide bond formation. Used for Bacterial infections in oral and maxillofacial surgery, Anaerobic bacterial infections, Gram-positive bacterial infections.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}