{"id":"da-9701","safety":{"commonSideEffects":[{"rate":null,"effect":"Diarrhea"},{"rate":null,"effect":"Abdominal pain"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Headache"}]},"_chembl":{"chemblId":"CHEMBL498283","moleculeType":"Small molecule","molecularWeight":"405.63"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"DA-9701 works through dual mechanisms: it blocks dopamine receptors (which inhibit gastric contractions) and inhibits acetylcholinesterase (which increases acetylcholine availability to promote gastric muscle contractions). This combination enhances gastric muscle function and accelerates the movement of food from the stomach into the small intestine, improving gastric emptying.","oneSentence":"DA-9701 enhances gastric motility and accelerates gastric emptying by acting as a dopamine antagonist and acetylcholinesterase inhibitor.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:31:38.586Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Functional dyspepsia"},{"name":"Gastroesophageal reflux disease (GERD)"}]},"trialDetails":[{"nctId":"NCT07096921","phase":"NA","title":"The Effect of Two Prokinetics in Patients With Functional Dyspepsia","status":"ACTIVE_NOT_RECRUITING","sponsor":"Eunpyeong St. Mary's Hospital","startDate":"2025-07-08","conditions":"Functional Dyspepsia","enrollment":92},{"nctId":"NCT02775591","phase":"PHASE4","title":"Effect of Short-term Motilitone Therapy on Health-related Quality of Life in PD Patients With Gastrointestinal Symptoms","status":"COMPLETED","sponsor":"Seoul National University Hospital","startDate":"2016-04","conditions":"Parkinson Disease, Dyspepsia","enrollment":147},{"nctId":"NCT03022201","phase":"PHASE4","title":"Comparing the Therapeutic Efficacy and Safety of DA-9701 With Domperidone in Patients With Parkinson's Disease","status":"COMPLETED","sponsor":"Seoul National University Hospital","startDate":"2013-05","conditions":"Parkinson's Disease,Idiopathic","enrollment":40},{"nctId":"NCT01669772","phase":"PHASE1, PHASE2","title":"Study on the Effects of DA-9701 on Gastrointestinal Motility on Healthy Adult Volunteers","status":"COMPLETED","sponsor":"Myung-gui Choi","startDate":"2012-03","conditions":"Healthy Volunteers","enrollment":31},{"nctId":"NCT02091635","phase":"NA","title":"Efficacy of Motilitone on Gastric Accommodation in Healthy Adult Patients: Evaluation Using MRI Method","status":"COMPLETED","sponsor":"Samsung Medical Center","startDate":"2013-08","conditions":"Dyspepsia","enrollment":40}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":38,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Motilitone","Motilitone placebo"],"phase":"marketed","status":"active","brandName":"DA-9701","genericName":"DA-9701","companyName":"Seoul National University Hospital","companyId":"seoul-national-university-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"DA-9701 enhances gastric motility and accelerates gastric emptying by acting as a dopamine antagonist and acetylcholinesterase inhibitor. Used for Functional dyspepsia, Gastroesophageal reflux disease (GERD).","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}