{"id":"da-8159-udenafil","safety":{"commonSideEffects":[{"rate":"10-15","effect":"Headache"},{"rate":"5-10","effect":"Flushing"},{"rate":"5-10","effect":"Dyspepsia"},{"rate":"5-10","effect":"Nasal congestion"},{"rate":"5-10","effect":"Back pain"},{"rate":"3-5","effect":"Myalgia"}]},"_chembl":{"chemblId":"CHEMBL2103849","moleculeType":"Small molecule","molecularWeight":"516.67"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Udenafil is a PDE5 inhibitor that works by blocking the enzyme responsible for degrading cyclic guanosine monophosphate (cGMP) in smooth muscle cells. By preventing cGMP breakdown, the drug allows sustained smooth muscle relaxation and vasodilation, particularly in the corpus cavernosum of the penis. This mechanism improves erectile function by enhancing blood flow and penile rigidity.","oneSentence":"DA-8159 (Udenafil) inhibits phosphodiesterase type 5 (PDE5), increasing cyclic GMP levels to promote smooth muscle relaxation and improve blood flow.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:45:36.737Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Erectile dysfunction"}]},"trialDetails":[{"nctId":"NCT03013751","phase":"PHASE3","title":"A Extension Study of Udenafil in Adolescents","status":"COMPLETED","sponsor":"Mezzion Pharma Co. Ltd","startDate":"2017-02-06","conditions":"Functional Single Ventricle Heart Disease","enrollment":301},{"nctId":"NCT05918211","phase":"PHASE3","title":"Fontan Udenafil Exercise Longitudinal Assessment Trial - 2","status":"RECRUITING","sponsor":"Mezzion Pharma Co. 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Used for Erectile dysfunction.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}