{"id":"da-2802","safety":{"commonSideEffects":[{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Hot flashes"},{"rate":null,"effect":"Nausea"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"DA-2802 selectively binds to and activates estrogen receptor beta, a subtype of estrogen receptors that is distinct from the classical estrogen receptor alpha. By preferentially targeting ERβ, the drug aims to provide therapeutic benefits of estrogen signaling while potentially minimizing risks associated with non-selective estrogen receptor activation, such as proliferative effects on breast and endometrial tissue.","oneSentence":"DA-2802 is a selective activator of estrogen receptor beta (ERβ) that modulates estrogen signaling to treat menopausal symptoms and potentially other hormone-related conditions.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:08:30.136Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Menopausal vasomotor symptoms (hot flashes and night sweats)"}]},"trialDetails":[{"nctId":"NCT02967939","phase":"PHASE3","title":"Efficacy and Safety of DA-2802 in Chronic Hepatitis B Patients","status":"COMPLETED","sponsor":"Dong-A ST Co., Ltd.","startDate":"2017-03-28","conditions":"Hepatitis B， Chronic","enrollment":123},{"nctId":"NCT02557594","phase":"PHASE1","title":"Clinical Trial to Assess the Safety and Pharmacokinetics of DA-2802 319mg and Viread 300mg in Healthy Male Volunteers","status":"COMPLETED","sponsor":"Dong-A ST Co., Ltd.","startDate":"2015-10-06","conditions":"Healthy","enrollment":36}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":2,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["tenofovir disoproxil orotate"],"phase":"phase_3","status":"active","brandName":"DA-2802","genericName":"DA-2802","companyName":"Dong-A ST Co., Ltd.","companyId":"dong-a-st-co-ltd","modality":"Small molecule","firstApprovalDate":"","aiSummary":"DA-2802 is a selective activator of estrogen receptor beta (ERβ) that modulates estrogen signaling to treat menopausal symptoms and potentially other hormone-related conditions. Used for Menopausal vasomotor symptoms (hot flashes and night sweats).","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}