{"id":"d-cycloserine","safety":{"commonSideEffects":[{"rate":null,"effect":"Peripheral neuropathy"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Psychosis or psychiatric symptoms"},{"rate":null,"effect":"Seizures"}]},"_chembl":{"chemblId":"CHEMBL771","moleculeType":"Small molecule","molecularWeight":"102.09"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"D-cycloserine binds to the glycine modulatory site on NMDA receptors, potentiating their function by facilitating the opening of the ion channel. This enhancement of NMDA receptor activity is thought to facilitate learning and memory consolidation, making it useful as an adjunctive agent in cognitive-behavioral therapy for anxiety and trauma-related disorders.","oneSentence":"D-cycloserine is a partial agonist at the N-methyl-D-aspartate (NMDA) receptor glycine site, enhancing glutamatergic neurotransmission in the central nervous system.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:44:03.793Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Tuberculosis (as an adjunctive agent)"},{"name":"Obsessive-compulsive disorder (adjunctive to cognitive-behavioral therapy)"},{"name":"Post-traumatic stress disorder (adjunctive to cognitive-behavioral therapy)"}]},"trialDetails":[{"nctId":"NCT07460947","phase":"PHASE1, PHASE2","title":"A Pilot Trial of One-Day Accelerated TMS and D-cycloserine in Suicidal Patients With Borderline Personality Disorder","status":"NOT_YET_RECRUITING","sponsor":"Mclean Hospital","startDate":"2026-03","conditions":"Borderline Personality Disorder (BPD)","enrollment":20},{"nctId":"NCT03780829","phase":"EARLY_PHASE1","title":"AIH for Spinal Cord Repair","status":"TERMINATED","sponsor":"VA Office of Research and Development","startDate":"2020-02-25","conditions":"SCI","enrollment":50},{"nctId":"NCT05994703","phase":"PHASE2","title":"Assisting Smokers to Switch to an e-Cigarette by Accelerating Learning of Adaptive Habits Using D-cycloserine","status":"COMPLETED","sponsor":"Rose Research Center, LLC","startDate":"2023-10-20","conditions":"Smoking Cessation, Harm Reduction","enrollment":25},{"nctId":"NCT05591677","phase":"PHASE2","title":"D-Cycloserine Augmentation of Intermittent Theta Burst Stimulation (iTBS) in Depression (COGENT)","status":"ACTIVE_NOT_RECRUITING","sponsor":"The Alfred","startDate":"2023-04-21","conditions":"Major Depressive Disorder","enrollment":180},{"nctId":"NCT07227103","phase":"PHASE2, PHASE3","title":"A Randomized, Double-Blind Controlled Comparison of NRX-101 vs. Placebo for Adults Being Treated With Transcranial Magnetic Stimulation for Treatment Resistant Depression","status":"NOT_YET_RECRUITING","sponsor":"NeuroRx, Inc.","startDate":"2026-03-01","conditions":"Treatment Resistant Depression","enrollment":120},{"nctId":"NCT07198685","phase":"NA","title":"6 Months of Bedaquiline(BDQ), Delamanid(DLM), Linezolid(LZD) and Levofloxacin(LFX) in RR-TB Patients in Hubei Province","status":"NOT_YET_RECRUITING","sponsor":"Wuhan Pulmonary Hospital","startDate":"2025-09-30","conditions":"Treat to Target, Treatment Duration","enrollment":52},{"nctId":"NCT05395494","phase":"PHASE2","title":"iTBS-DCS in Fibromyalgia","status":"TERMINATED","sponsor":"University of Calgary","startDate":"2022-08-29","conditions":"Fibromyalgia","enrollment":47},{"nctId":"NCT06121284","phase":"PHASE2","title":"iTBS+D-Cycloserine for Youth Suicide","status":"RECRUITING","sponsor":"University of Calgary","startDate":"2024-03-11","conditions":"Suicidal Ideation, Suicide, Attempted, Depression, Anxiety","enrollment":54},{"nctId":"NCT03535688","phase":"PHASE2","title":"D-cycloserine for the Treatment of Chronic, Refractory Low Back Pain","status":"TERMINATED","sponsor":"Northwestern University","startDate":"2018-03-30","conditions":"Low Back Pain, Pain","enrollment":203},{"nctId":"NCT03395392","phase":"PHASE2, PHASE3","title":"NRX-101 for Bipolar Depression With Subacute Suicidal Ideation","status":"COMPLETED","sponsor":"NeuroRx, Inc.","startDate":"2022-05-12","conditions":"Bipolar Depression, Suicidal Ideation and Behavior","enrollment":74},{"nctId":"NCT01450306","phase":"NA","title":"Exposure, D-cycloserine Enhancement, and Functional Magnetic Resonance Imaging (fMRI) in Snake Phobics","status":"COMPLETED","sponsor":"Hartford Hospital","startDate":"2010-07","conditions":"Specific Phobia","enrollment":20},{"nctId":"NCT03396068","phase":"PHASE3","title":"NRX-101 for Maintenance of Remission From Severe Bipolar Depression in Patients With Suicidal Ideation","status":"UNKNOWN","sponsor":"NeuroRx, Inc.","startDate":"2019-12-01","conditions":"Bipolar Depression, Suicidal Ideation","enrollment":72},{"nctId":"NCT06128213","phase":"PHASE2","title":"NRX-101 for Complicated Urinary Tract Infection (UTI) Including Pyelonephritis","status":"UNKNOWN","sponsor":"NeuroRx, Inc.","startDate":"2024-03-31","conditions":"Urinary Tract Infections, Pyelonephritis","enrollment":13},{"nctId":"NCT05177601","phase":"PHASE2","title":"iTBS-DCS in Obsessive Compulsive Disorder","status":"UNKNOWN","sponsor":"University of Calgary","startDate":"2021-11-26","conditions":"Obsessive-Compulsive Disorder","enrollment":81},{"nctId":"NCT05731323","phase":"PHASE1","title":"D-Cycloserine+iTBS PK Study","status":"COMPLETED","sponsor":"University of Calgary","startDate":"2022-10-12","conditions":"Major Depressive Disorder","enrollment":12},{"nctId":"NCT05081986","phase":"PHASE2","title":"Repeated iTBS Cycloserine Motor Plasticity","status":"COMPLETED","sponsor":"University of Calgary","startDate":"2021-08-18","conditions":"Motor Activity","enrollment":20},{"nctId":"NCT02385266","phase":"PHASE4","title":"Treating Urological Chronic Pelvic Pain Syndrome (UCPPS) Pain","status":"TERMINATED","sponsor":"Northwestern University","startDate":"2013-09","conditions":"Chronic Prostatitis With Chronic Pelvic Pain Syndrome","enrollment":24},{"nctId":"NCT02099825","phase":"PHASE1","title":"Medication Enhanced Rapid Therapy","status":"TERMINATED","sponsor":"Washington University School of Medicine","startDate":"2014-01-13","conditions":"Anxiety Disorders","enrollment":15},{"nctId":"NCT04357951","phase":"EARLY_PHASE1","title":"D-cycloserine Augmented Treatment for Youth With Tic Disorders","status":"WITHDRAWN","sponsor":"Johns Hopkins University","startDate":"2023-04-15","conditions":"Tourette Syndrome","enrollment":""},{"nctId":"NCT05779267","phase":"","title":"NRX-101 Expanded Access","status":"AVAILABLE","sponsor":"NeuroRx, Inc.","startDate":"","conditions":"Bipolar Depression, Bipolar Affective Disorder","enrollment":""},{"nctId":"NCT03216356","phase":"PHASE2, PHASE3","title":"Effect of D-cycloserine on a Short Imagery Rescripting Intervention for Subclinical PTSD","status":"WITHDRAWN","sponsor":"Boston University Charles River Campus","startDate":"2016-09","conditions":"PTSD","enrollment":""},{"nctId":"NCT01512316","phase":"NA","title":"Exploring Learning and Unlearning of Fear","status":"WITHDRAWN","sponsor":"Universitaire Ziekenhuizen KU Leuven","startDate":"","conditions":"Healthy Individuals","enrollment":""},{"nctId":"NCT03402152","phase":"PHASE2, PHASE3","title":"NRX101 Glx Biomarker Validation Study","status":"COMPLETED","sponsor":"NeuroRx, Inc.","startDate":"2018-11-01","conditions":"Bipolar Depression, Suicidal Ideation","enrollment":8},{"nctId":"NCT04762836","phase":"NA","title":"Pain, Learning, and Nocebo","status":"COMPLETED","sponsor":"Leiden University Medical Center","startDate":"2021-02-28","conditions":"Chronic Pain, Pain Syndrome","enrollment":53},{"nctId":"NCT03937596","phase":"PHASE2","title":"Adjunctive D-Cycloserine in Major Depressive Disorder","status":"COMPLETED","sponsor":"University of Calgary","startDate":"2019-12-01","conditions":"Major Depressive Disorder","enrollment":50},{"nctId":"NCT03511599","phase":"PHASE1","title":"Cycloserine rTMS Plasticity Augmentation in Depression","status":"COMPLETED","sponsor":"University of Calgary","startDate":"2018-09-03","conditions":"Major Depressive Disorder","enrollment":12},{"nctId":"NCT00875342","phase":"NA","title":"Imaginal Exposure & D-Cycloserine (DCS) for Posttraumatic Stress Disorder (PTSD)","status":"TERMINATED","sponsor":"Weill Medical College of Cornell University","startDate":"2008-05","conditions":"Posttraumatic Stress Disorder","enrollment":41},{"nctId":"NCT02635893","phase":"PHASE4","title":"Lower Limb Function After Spinal Cord Injury","status":"COMPLETED","sponsor":"Shirley Ryan AbilityLab","startDate":"2019-06-21","conditions":"Spinal Cord Injury","enrollment":257},{"nctId":"NCT02974010","phase":"PHASE2","title":"Sequential Therapy for the Treatment of Severe Bipolar Depression.","status":"COMPLETED","sponsor":"NeuroRx, Inc.","startDate":"2018-01-15","conditions":"Bipolar Depression, Suicidal Ideas, Suicidal Ideation","enrollment":22},{"nctId":"NCT01944423","phase":"EARLY_PHASE1","title":"Enhancing Panic and Smoking Reduction Treatment With D-Cycloserine","status":"COMPLETED","sponsor":"University of Texas at Austin","startDate":"2013-10","conditions":"Nicotine Addiction, Panic Attack","enrollment":53},{"nctId":"NCT01361633","phase":"PHASE2","title":"The Cognitive Enhancing Effects of D-Cycloserine Among Non-Demented Elderly","status":"COMPLETED","sponsor":"Hartford Hospital","startDate":"2008-01","conditions":"Treatment, Placebo","enrollment":51},{"nctId":"NCT04035603","phase":"PHASE2","title":"Multimodal Cue Exposure Therapy for Smoking Cessation","status":"WITHDRAWN","sponsor":"Boston University Charles River Campus","startDate":"2020-10-01","conditions":"Smoking Cessation","enrollment":""},{"nctId":"NCT02656342","phase":"PHASE4","title":"Translational Approach to the Understanding and Treatment of Obsessive-Compulsive Disorder (OCD). Can D-Cycloserine Enhance and Stabilize the Treatment-response in Relapsed and Non-responding OCD-patients?","status":"COMPLETED","sponsor":"Haukeland University Hospital","startDate":"2015-11","conditions":"Obsessive-Compulsive Disorder","enrollment":163},{"nctId":"NCT01907594","phase":"PHASE2","title":"Effects of Nicotine Replacement Therapy and D-cycloserine on Nicotine Treatment Seekers","status":"WITHDRAWN","sponsor":"New York State Psychiatric Institute","startDate":"2013-08","conditions":"Cigarette Smoking","enrollment":""},{"nctId":"NCT03062150","phase":"NA","title":"Mineralocorticoid Receptor, NMDA Receptor and Cognitive Function in Depression","status":"COMPLETED","sponsor":"Charite University, Berlin, Germany","startDate":"2016-09-27","conditions":"Major Depression","enrollment":232},{"nctId":"NCT01934972","phase":"PHASE3","title":"A Randomized Controlled Trial of Cognitive Remediation and D-cycloserine for Individuals With Bipolar Disorder","status":"COMPLETED","sponsor":"University of Arizona","startDate":"2013-03","conditions":"Bipolar Disorder","enrollment":30},{"nctId":"NCT02066792","phase":"EARLY_PHASE1","title":"Dose Timing of D-Cycloserine to Augment CBT for Social Anxiety Disorder","status":"COMPLETED","sponsor":"University of Texas at Austin","startDate":"2014-04","conditions":"Social Anxiety Disorder","enrollment":152},{"nctId":"NCT02687165","phase":"NA","title":"Uncovering Neural and Immune Mechanisms of Chronic Pain in Post Treatment Lyme Syndrome","status":"TERMINATED","sponsor":"New York State Psychiatric Institute","startDate":"2016-01-16","conditions":"Post Treatment Lyme Syndrome (PTLS), Chronic Pain","enrollment":4},{"nctId":"NCT01981759","phase":"PHASE4","title":"D-Cycloserine Augmentation of Cognitive Behavioral Therapy for Delusions","status":"COMPLETED","sponsor":"NYU Langone Health","startDate":"2014-02","conditions":"Schizophrenia, Schizoaffective Disorder, Delusional Disorder","enrollment":58},{"nctId":"NCT02735694","phase":"PHASE1","title":"Cycloserine in the Treatment of Sleep Apnea","status":"TERMINATED","sponsor":"University of Manitoba","startDate":"2015-09","conditions":"Sleep Apnea Syndromes","enrollment":18},{"nctId":"NCT00222235","phase":"PHASE2, PHASE3","title":"Adjunctive Treatment for Decreasing Symptoms of Schizophrenia","status":"COMPLETED","sponsor":"University of Maryland, Baltimore","startDate":"2000-01","conditions":"Schizophrenia, Schizoaffective Disorder","enrollment":240},{"nctId":"NCT01352637","phase":"PHASE3","title":"Enhancing Exposure Therapy for Post Traumatic Stress Disorder (PTSD): Virtual Reality and Imaginal Exposure With a Cognitive Enhancer","status":"COMPLETED","sponsor":"Weill Medical College of Cornell University","startDate":"2011-05","conditions":"Post Traumatic Stress Disorder","enrollment":192},{"nctId":"NCT00842309","phase":"EARLY_PHASE1","title":"D-Cycloserine Augmentation of Behavior Therapy for Individuals With Body Dysmorphic Disorder","status":"COMPLETED","sponsor":"Massachusetts General Hospital","startDate":"2008-11","conditions":"Body Dysmorphic Disorder","enrollment":68},{"nctId":"NCT00674570","phase":"PHASE4","title":"Veteran Stress and Learning Study","status":"COMPLETED","sponsor":"VA Office of Research and Development","startDate":"2009-01-13","conditions":"Stress Disorders, Posttraumatic","enrollment":111},{"nctId":"NCT03961464","phase":"NA","title":"The Effect of D-cycloserine on Emotional Processing","status":"COMPLETED","sponsor":"University of Oxford","startDate":"2018-08-10","conditions":"Cycloserine, Healthy Volunteer","enrollment":40},{"nctId":"NCT02582515","phase":"NA","title":"Augmentation of Brief Habit Reversal Training With D-cycloserine or Placebo","status":"COMPLETED","sponsor":"University of California, Los Angeles","startDate":"2015-10","conditions":"Tourette Disorder, Chronic Tic Disorder","enrollment":20},{"nctId":"NCT00198107","phase":"PHASE3","title":"Evaluating the Effectiveness of Aripiprazole and D-Cycloserine to Treat Symptoms Associated With Autism","status":"COMPLETED","sponsor":"Indiana University","startDate":"2005-09","conditions":"Autistic Disorder","enrollment":81},{"nctId":"NCT00515879","phase":"PHASE3","title":"Effect of D-cycloserine Plus Cognitive Behavioral Therapy on People With Social Phobia","status":"COMPLETED","sponsor":"Boston University Charles River Campus","startDate":"2007-12","conditions":"Social Anxiety Disorder","enrollment":169},{"nctId":"NCT02983734","phase":"PHASE2","title":"D-cycloserine: A Novel Treatment for Gulf War Illness (GWDCS)","status":"UNKNOWN","sponsor":"Boston University Charles River Campus","startDate":"2015-10","conditions":"Gulf War Illness","enrollment":56},{"nctId":"NCT03432689","phase":"PHASE1","title":"Cycloserine rTMS Plasticity Augmentation","status":"COMPLETED","sponsor":"University of Calgary","startDate":"2018-08-06","conditions":"Motor Activity","enrollment":12},{"nctId":"NCT02082912","phase":"PHASE2","title":"NMDA Receptors in Motor Learning in Humans","status":"COMPLETED","sponsor":"Emory University","startDate":"2010-06","conditions":"Stroke","enrollment":14},{"nctId":"NCT01985750","phase":"EARLY_PHASE1","title":"Understanding the Importance of Plasticity in the Brain Mechanisms of Dyspnoea Perception","status":"UNKNOWN","sponsor":"University of Oxford","startDate":"2013-11","conditions":"Chronic Obstructive Pulmonary Disease","enrollment":90},{"nctId":"NCT01399866","phase":"PHASE3","title":"Cognitive Remediation With D-Cycloserine","status":"COMPLETED","sponsor":"Massachusetts General Hospital","startDate":"2011-05","conditions":"Smoking Cessation","enrollment":150},{"nctId":"NCT02376257","phase":"PHASE2","title":"Improving Therapeutic Learning in Depression: Proof of Concept","status":"COMPLETED","sponsor":"Boston University Charles River Campus","startDate":"2014-09-16","conditions":"Major Depressive Disorder","enrollment":36},{"nctId":"NCT01842334","phase":"PHASE1, PHASE2","title":"D-cycloserine (DCS) Pretreatment + CBT + Nicotine Replacement Therapy for Smoking Cessation (DCS)","status":"TERMINATED","sponsor":"Mclean Hospital","startDate":"2013-04","conditions":"Nicotine Dependence, Smoking Cessation","enrollment":22},{"nctId":"NCT00780442","phase":"PHASE2","title":"D-Cycloserine and Cue Exposure in Cocaine-Dependent Individuals","status":"COMPLETED","sponsor":"Medical University of South Carolina","startDate":"2006-09","conditions":"Cocaine Use Disorders","enrollment":27},{"nctId":"NCT00430573","phase":"PHASE2","title":"Efficacy of D-Cycloserine for Enhancing the Effects of CBT for Substance Use","status":"TERMINATED","sponsor":"Boston University Charles River Campus","startDate":"2007-02","conditions":"Substance-Related Disorders","enrollment":15},{"nctId":"NCT01680107","phase":"PHASE3","title":"D-cycloserine Augmented CBT for Panic Disorder","status":"TERMINATED","sponsor":"University of Oxford","startDate":"2012-10","conditions":"Panic Disorder","enrollment":33},{"nctId":"NCT02933684","phase":"PHASE2","title":"D-Cycloserine and Virtual Reality Exposure Therapy","status":"WITHDRAWN","sponsor":"Georgia State University","startDate":"2015-01-01","conditions":"Social Anxiety Disorder","enrollment":""},{"nctId":"NCT00790868","phase":"PHASE2","title":"Exposure, D-Cycloserine Enhancement, and Genetic Modulators in Panic Disorder","status":"COMPLETED","sponsor":"Boston University Charles River Campus","startDate":"2008-04","conditions":"Panic Disorder","enrollment":180},{"nctId":"NCT00963924","phase":"NA","title":"D-cycloserine Augmentation of Cognitive Remediation in Schizophrenia","status":"COMPLETED","sponsor":"Massachusetts General Hospital","startDate":"2009-08","conditions":"Schizophrenia","enrollment":54},{"nctId":"NCT01411774","phase":"PHASE3","title":"D-cycloserine Augmentation of Cognitive Behavioral Therapy (CBT) for Pediatric Obsessive-compulsive Disorder (OCD)","status":"COMPLETED","sponsor":"University of South Florida","startDate":"2011-06","conditions":"Obsessive-compulsive Disorder","enrollment":142},{"nctId":"NCT00742079","phase":"PHASE4","title":"Using D-cycloserine to Enhance the Benefits of Cognitive Behavioral Therapy for Schizophrenia","status":"COMPLETED","sponsor":"Massachusetts General Hospital","startDate":"2006-09","conditions":"Schizophrenia","enrollment":21},{"nctId":"NCT02304432","phase":"EARLY_PHASE1","title":"Targeting a Genetic Mutation in Glycine Metabolism With D-cycloserine","status":"COMPLETED","sponsor":"Mclean Hospital","startDate":"2015-09-27","conditions":"Schizophrenia, Bipolar Disorder","enrollment":2},{"nctId":"NCT00352586","phase":"","title":"Effect of D-cycloserine on Extinction of Fear Conditioning","status":"COMPLETED","sponsor":"National Institute of Mental Health (NIMH)","startDate":"2002-04-03","conditions":"Fear","enrollment":160},{"nctId":"NCT01490697","phase":"PHASE4","title":"Developing Memory Reconsolidation Blockers as Novel Posttraumatic Stress Disorder (PTSD) Treatments","status":"COMPLETED","sponsor":"Roger K. Pitman, MD","startDate":"2009-03","conditions":"Post-traumatic Stress Disorder","enrollment":34},{"nctId":"NCT01157429","phase":"PHASE2","title":"D-cycloserine Adjunctive Treatment for Posttraumatic Stress Disorder (PTSD) in Adolescents","status":"COMPLETED","sponsor":"Tulane University School of Medicine","startDate":"2010-06","conditions":"Posttraumatic Stress Disorder, PTSD","enrollment":24},{"nctId":"NCT00591825","phase":"PHASE2","title":"fMRI Study Examining Effects of D-cycloserine in Specific Phobia","status":"COMPLETED","sponsor":"University of Kansas Medical Center","startDate":"2006-03","conditions":"Phobias","enrollment":54},{"nctId":"NCT01733030","phase":"","title":"The Effects of D-cycloserine on Stimulus Generalization of Conditioned Fear Healthy Controls.","status":"COMPLETED","sponsor":"University of Minnesota","startDate":"2013-01","conditions":"Post Traumatic Stress Syndrome","enrollment":56},{"nctId":"NCT00827281","phase":"PHASE2","title":"D-Cycloserine Enhancement of Exposure-Based CBT for Smoking Cessation (DCSSmoking)","status":"WITHDRAWN","sponsor":"Boston University Charles River Campus","startDate":"2008-08","conditions":"Smokers","enrollment":""},{"nctId":"NCT01157416","phase":"PHASE2","title":"Effect of D-cycloserine on Treatment of Posttraumatic Stress Disorder (PTSD) in Youth","status":"COMPLETED","sponsor":"Tulane University School of Medicine","startDate":"2010-06","conditions":"Posttraumatic Stress Disorders, PTSD","enrollment":33},{"nctId":"NCT01404208","phase":"NA","title":"2/2 D-Cycloserine Augmentation of CBT for Pediatric OCD","status":"COMPLETED","sponsor":"Massachusetts General Hospital","startDate":"2011-07","conditions":"Obsessive-Compulsive Disorder","enrollment":206},{"nctId":"NCT01526538","phase":"PHASE2","title":"Improving Learning-based Treatment of Cocaine Dependence With Medication","status":"COMPLETED","sponsor":"Johns Hopkins University","startDate":"2011-09","conditions":"COCAINE-RELATED DISORDERS","enrollment":52},{"nctId":"NCT00125528","phase":"PHASE2","title":"D-cycloserine in the Management of Chronic Low Back Pain","status":"COMPLETED","sponsor":"Thomas J. Schnitzer","startDate":"2012-07","conditions":"Low Back Pain, Pain","enrollment":41},{"nctId":"NCT00635102","phase":"NA","title":"Glycine and Oral D-Cycloserine in Alcoholic Patients and Healthy Subjects","status":"COMPLETED","sponsor":"Yale University","startDate":"1997-10","conditions":"Alcohol Dependence","enrollment":57},{"nctId":"NCT01649895","phase":"PHASE4","title":"D-Cycloserine as an Adjunct to Internet-CBT for OCD","status":"COMPLETED","sponsor":"Christian Rück","startDate":"2012-08","conditions":"Obsessive-compulsive Disorder","enrollment":128},{"nctId":"NCT01833897","phase":"PHASE4","title":"NMDA Antagonists in Bipolar Depression","status":"COMPLETED","sponsor":"New York State Psychiatric Institute","startDate":"2013-03","conditions":"Bipolar Disorder","enrollment":8},{"nctId":"NCT02772211","phase":"PHASE4","title":"D-cycloserine for Relapse Prevention Following Intravenous Ketamine in Treatment-resistant Depression","status":"UNKNOWN","sponsor":"Sheba Medical Center","startDate":"2016-06","conditions":"Treatment Resistant Depression","enrollment":60},{"nctId":"NCT02769936","phase":"PHASE1","title":"Glutamate, Learning, and Working Memory","status":"COMPLETED","sponsor":"University of California, Los Angeles","startDate":"2013-11","conditions":"Schizophrenia","enrollment":110},{"nctId":"NCT01086475","phase":"PHASE3","title":"D-Cycloserine and Social Skills Training in Autism Spectrum Disorders","status":"COMPLETED","sponsor":"Indiana University","startDate":"2010-03","conditions":"Autistic Disorder, Asperger's Disorder, Pervasive Developmental Disorder NOS","enrollment":68},{"nctId":"NCT00759473","phase":"PHASE2","title":"D-Cycloserine Facilitation of Cocaine - Cue Extinction","status":"COMPLETED","sponsor":"Medical University of South Carolina","startDate":"2008-09","conditions":"Cocaine Use Disorders","enrollment":79},{"nctId":"NCT00198120","phase":"PHASE3","title":"Safety and Effectiveness of D-Cycloserine in Children With Autism","status":"COMPLETED","sponsor":"Indiana University","startDate":"2004-02","conditions":"Autistic Disorder","enrollment":80},{"nctId":"NCT00356278","phase":"PHASE2, PHASE3","title":"D-cycloserine and Virtual Reality Exposure to Treat Iraq War Veterans With PTSD","status":"COMPLETED","sponsor":"Emory University","startDate":"2006-09","conditions":"Stress Disorder, Post Traumatic","enrollment":156},{"nctId":"NCT00632632","phase":"NA","title":"Virtual Reality & D-cycloserine (DCS) for Posttraumatic Stress Disorder (PTSD)","status":"COMPLETED","sponsor":"Weill Medical College of Cornell University","startDate":"2005-01","conditions":"Posttraumatic Stress Disorder","enrollment":25},{"nctId":"NCT02312635","phase":"EARLY_PHASE1","title":"Augmentation of Cognitive Training in Children With TBI With D-Cyloserine","status":"UNKNOWN","sponsor":"University of California, Los Angeles","startDate":"2012-12","conditions":"Traumatic Brain Injury","enrollment":30},{"nctId":"NCT00980408","phase":"NA","title":"The Influence of Glutamate on Memory in Humans","status":"COMPLETED","sponsor":"University Hospital, Bonn","startDate":"2008-06","conditions":"Healthy Individuals","enrollment":120},{"nctId":"NCT01923896","phase":"PHASE1, PHASE2","title":"D-cycloserine and Treatment of Feeding Disorders","status":"COMPLETED","sponsor":"Emory University","startDate":"2013-03","conditions":"Feeding Disorders, Specific Phobia","enrollment":16},{"nctId":"NCT00000371","phase":"PHASE3","title":"Trial of D-Cycloserine in Schizophrenia","status":"COMPLETED","sponsor":"Massachusetts General Hospital","startDate":"1996-08","conditions":"Schizophrenia","enrollment":60},{"nctId":"NCT01172873","phase":"NA","title":"D-Cycloserine Augmentation to CBT With Exposure and Response Prevention in Adults and Adolescents With OCD","status":"COMPLETED","sponsor":"New York State Psychiatric Institute","startDate":"2008-09","conditions":"Obsessive Compulsive Disorder","enrollment":16},{"nctId":"NCT00455702","phase":"PHASE4","title":"Effects of Weekly Dosing of D-cycloserine on Cognitive Function in Individuals With Schizophrenia","status":"COMPLETED","sponsor":"Massachusetts General Hospital","startDate":"2004-07","conditions":"Schizophrenia","enrollment":38},{"nctId":"NCT00000372","phase":"PHASE3","title":"Glycine and D-Cycloserine in Schizophrenia","status":"WITHDRAWN","sponsor":"Massachusetts General Hospital","startDate":"1998-03","conditions":"Schizophrenia","enrollment":""},{"nctId":"NCT00128401","phase":"PHASE2","title":"Use of an Antibiotic as an Enhancer for the Treatment of Social Phobia","status":"COMPLETED","sponsor":"National Institute of Mental Health (NIMH)","startDate":"2005-08","conditions":"Phobic Disorders, Anxiety, Social Phobia","enrollment":48},{"nctId":"NCT01928823","phase":"PHASE2","title":"Augmentation of Psychotherapy With D-Cycloserine in Agoraphobia","status":"COMPLETED","sponsor":"Charite University, Berlin, Germany","startDate":"2011-11","conditions":"Agoraphobia","enrollment":73},{"nctId":"NCT00633984","phase":"PHASE4","title":"D-Cycloserine Enhancement of Exposure in Social Phobia","status":"COMPLETED","sponsor":"Massachusetts General Hospital","startDate":"2007-03","conditions":"Social Anxiety Disorder","enrollment":169},{"nctId":"NCT00720759","phase":"PHASE2","title":"Improving Stroke Rehabilitation: Spacing Effect and D-cycloserine","status":"COMPLETED","sponsor":"US Department of Veterans Affairs","startDate":"2009-07","conditions":"Stroke","enrollment":24},{"nctId":"NCT01362309","phase":"NA","title":"D-Cycloserine to Enhance Extinction to Alcohol Cues","status":"COMPLETED","sponsor":"University of Georgia","startDate":"2010-11","conditions":"Alcohol Use Disorders.","enrollment":37},{"nctId":"NCT00371176","phase":"NA","title":"A Placebo-Controlled Trial of D-Cycloserine and Exposure Therapy for Combat-PTSD","status":"COMPLETED","sponsor":"US Department of Veterans Affairs","startDate":"2006-10","conditions":"Combat Disorders, Stress Disorders, Post-Traumatic","enrollment":26},{"nctId":"NCT00301080","phase":"PHASE3","title":"D-cycloserine in the Management of Chemotherapy-Induced Peripheral Neuropathic Pain","status":"TERMINATED","sponsor":"Northwestern University","startDate":"2006-02","conditions":"Neurotoxicity, Pain, Breast Cancer","enrollment":7},{"nctId":"NCT01067846","phase":"NA","title":"Cognitive Enhancement and Relapse Prevention in Cocaine Addiction","status":"COMPLETED","sponsor":"University of Arkansas","startDate":"2010-06","conditions":"Cocaine Addiction","enrollment":85},{"nctId":"NCT00964041","phase":"PHASE4","title":"Once Weekly D-cycloserine for Schizophrenia","status":"WITHDRAWN","sponsor":"Massachusetts General Hospital","startDate":"2009-07","conditions":"Schizophrenia","enrollment":""}],"_emaApprovals":[],"_faersSignals":[{"count":3,"reaction":"DRUG RESISTANCE"},{"count":2,"reaction":"PATHOGEN RESISTANCE"},{"count":1,"reaction":"OFF LABEL USE"},{"count":1,"reaction":"PAIN IN EXTREMITY"},{"count":1,"reaction":"VOMITING"}],"_approvalHistory":[],"publicationCount":1375,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Experimental Group","Cycloserine","Seromycin","Cycloserine, King Pharmaceuticals Ltd","D-cycloserine, Cycloserine, DCS"],"phase":"marketed","status":"active","brandName":"d-cycloserine","genericName":"d-cycloserine","companyName":"Massachusetts General Hospital","companyId":"massachusetts-general-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"D-cycloserine is a partial agonist at the N-methyl-D-aspartate (NMDA) receptor glycine site, enhancing glutamatergic neurotransmission in the central nervous system. Used for Tuberculosis (as an adjunctive agent), Obsessive-compulsive disorder (adjunctive to cognitive-behavioral therapy), Post-traumatic stress disorder (adjunctive to cognitive-behavioral therapy).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}