{"id":"cytotec-reference-drug","safety":{"commonSideEffects":[{"rate":"13–40","effect":"Diarrhea"},{"rate":"7–20","effect":"Abdominal pain"},{"rate":"3–7","effect":"Nausea"},{"rate":"2–6","effect":"Flatulence"},{"rate":"2–6","effect":"Headache"}]},"_chembl":{"chemblId":"CHEMBL3672588","moleculeType":"Small molecule","molecularWeight":"415.54"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Misoprostol binds to prostaglandin receptors on gastric parietal cells, inhibiting acid secretion while simultaneously increasing mucus and bicarbonate production to strengthen the protective gastric lining. It is commonly used to prevent nonsteroidal anti-inflammatory drug (NSAID)-induced gastric ulcers by restoring the balance between aggressive acid and protective mechanisms.","oneSentence":"Cytotec (misoprostol) is a prostaglandin E1 analog that reduces gastric acid secretion and protects the gastric mucosa.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:30:17.019Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention of NSAID-induced gastric ulcers"},{"name":"Treatment of gastric ulcers"}]},"trialDetails":[{"nctId":"NCT01912066","phase":"PHASE4","title":"A Multicenter, Double Blinded, Randomized, Parallel Assignment Study to Demonstrate the Efficacy of DA9601","status":"COMPLETED","sponsor":"Dong-A ST Co., Ltd.","startDate":"2012-09","conditions":"NSAID-associated Gastroduodenal Injury","enrollment":520}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":2,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Cytotec (reference drug)","genericName":"Cytotec (reference drug)","companyName":"Dong-A ST Co., Ltd.","companyId":"dong-a-st-co-ltd","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Cytotec (misoprostol) is a prostaglandin E1 analog that reduces gastric acid secretion and protects the gastric mucosa. Used for Prevention of NSAID-induced gastric ulcers, Treatment of gastric ulcers.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}