{"id":"cyprodenate","rwe":[{"pmid":"37761116","year":"2023","title":"Integrated Transcriptomics and Metabolomics Reveal the Mechanism of Alliin in Improving Hyperlipidemia.","finding":"","journal":"Foods (Basel, Switzerland)","studyType":"Clinical Study"},{"pmid":"1173033","year":"1975","title":"Pharmacokinetic study of maleate acid of 2-(N,N-dimethylaminoethanol-14C1)-cyclohexylpropionate (cyprodenate) and of N,N-dimethylaminoethanol-14C1 in animals.","finding":"","journal":"Arzneimittel-Forschung","studyType":"Clinical Study"},{"pmid":"1173032","year":"1975","title":"Pharmacokinetic study of maleate acid of 2-(N,N-dimethylaminoethanol-14C1)-cyclohexylpropionate (cyprodenate) and of N,N-dimethylaminoethanol-14C1 in animals.","finding":"","journal":"Arzneimittel-Forschung","studyType":"Clinical Study"},{"pmid":"4575344","year":"1972","title":"[The use of Wittenborn psychiatric rating scales in geriatric psychiatry. Results of a double blind study with cyprodenate and placebo].","finding":"","journal":"Arzneimittel-Forschung","studyType":"Clinical Study"}],"tags":[{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"actebral","offLabel":[],"synonyms":["cyprodenate","actebral","cyprodemanol"],"timeline":[],"approvals":[],"brandName":"Actebral","ecosystem":[],"mechanism":{"modality":"Small Molecule","explanation":"Imagine your body's cells are like locks, and Actebral is a key that fits into one of those locks. When it binds to the lock, it triggers a series of events that ultimately lead to the desired therapeutic effect, such as reducing inflammation or killing cancer cells.","oneSentence":"Actebral works by interacting with a specific molecular target to produce a therapeutic effect.","technicalDetail":"Actebral is a small molecule that binds to a specific protein target, modulating its activity and leading to a downstream effect on cellular processes."},"_wikipedia":{"url":"https://en.wikipedia.org/wiki/Cyprodenate","title":"Cyprodenate","extract":"Cyprodenate (Actebral) is a stimulant drug. It was used for counteracting the effects of benzodiazepine tranquillizer drugs before the development of newer antidotes such as flumazenil. It produces dimethylethanolamine as a metabolite."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/764","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=CYPRODENATE","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=CYPRODENATE","fields":["publications"],"source":"PubMed/NCBI"},{"id":4,"url":"https://en.wikipedia.org/wiki/Cyprodenate","fields":["history","overview"],"source":"Wikipedia"}],"_enrichedAt":"2026-03-30T10:22:31.455343","biosimilars":[],"competitors":[],"genericName":"cyprodenate","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[{"nctId":"NCT00071461","phase":"PHASE2,PHASE3","title":"Efficacy and Safety of Oral Bosentan in Patients With Idiopathic Pulmonary Fibrosis","status":"COMPLETED","sponsor":"Actelion","startDate":"2003-08","conditions":["Idiopathic Pulmonary Fibrosis"],"enrollment":158,"completionDate":"2010-05"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"005798","UNII":"I44VIC13P8","CHEBI":"CHEBI:134934","INN_ID":"2270","RXNORM":"22051","UMLSCUI":"C0056852","ChEMBL_ID":"CHEMBL2106590","KEGG_DRUG":"D07764","PUBCHEM_CID":"71875","MESH_SUPPLEMENTAL_RECORD_UI":"C000027"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":4,"therapeuticAreas":["Oncology"],"biosimilarFilings":[],"recentPublications":[{"date":"2023 Sep 13","pmid":"37761116","title":"Integrated Transcriptomics and Metabolomics Reveal the Mechanism of Alliin in Improving Hyperlipidemia.","journal":"Foods (Basel, Switzerland)"},{"date":"1975 Feb","pmid":"1173033","title":"Pharmacokinetic study of maleate acid of 2-(N,N-dimethylaminoethanol-14C1)-cyclohexylpropionate (cyprodenate) and of N,N-dimethylaminoethanol-14C1 in animals.","journal":"Arzneimittel-Forschung"},{"date":"1975 Feb","pmid":"1173032","title":"Pharmacokinetic study of maleate acid of 2-(N,N-dimethylaminoethanol-14C1)-cyclohexylpropionate (cyprodenate) and of N,N-dimethylaminoethanol-14C1 in animals.","journal":"Arzneimittel-Forschung"},{"date":"1972 Dec","pmid":"4575344","title":"[The use of Wittenborn psychiatric rating scales in geriatric psychiatry. Results of a double blind study with cyprodenate and placebo].","journal":"Arzneimittel-Forschung"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Actebral is a small molecule with the synonyms ACTEBRAL, CIPRODENATO, CYPRODENATE, LB 125, LB-125, and RD 406. It is being studied in a clinical trial for the treatment of Idiopathic Pulmonary Fibrosis, where it is being compared to a placebo in combination with bosentan.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":true,"score":2}}