{"id":"cypermethrin","rwe":[{"pmid":"41889148","year":"2026","title":"Protective Effects of Sesame Seed Oil Nanoemulsion Against Cypermethrin-Induced Testicular Toxicity Through Modulation of Oxidative Stress and Apoptotic Signaling in Rats.","finding":"","journal":"Environmental toxicology","studyType":"Clinical Study"},{"pmid":"41888607","year":"2026","title":"Investigating zeta-cypermethrin resistance stability in California Drosophila suzukii populations.","finding":"","journal":"Pest management science","studyType":"Clinical Study"},{"pmid":"41887755","year":"2026","title":"Metabolic Assays and RNAi-Based Functional Characterization of the P450 Gene CYP6AQ1 under Environmental Stress in Apis cerana cerana.","finding":"","journal":"Journal of agricultural and food chemistry","studyType":"Clinical Study"},{"pmid":"41887020","year":"2026","title":"Rapid assessment of pesticide toxicity in aquatic ecosystems using deep learning-based automatic duckweed counting method.","finding":"","journal":"Aquatic toxicology (Amsterdam, Netherlands)","studyType":"Clinical Study"},{"pmid":"41886784","year":"2026","title":"Insecticide Susceptibility of Phlebotomus argentipes and Residual Action of Alpha-Cypermethrin in India: A Multicenter Study.","finding":"","journal":"The American journal of tropical medicine and hygiene","studyType":"Clinical Study"}],"tags":[{"label":"cypermethrin","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"P03BA02","category":"atc"},{"label":"Active","category":"status"},{"label":"Insecticides","category":"pharmacology"},{"label":"Pesticides","category":"pharmacology"}],"phase":"unknown","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":["cypermethrin"],"offLabel":[],"synonyms":["cypermethrin"],"timeline":[],"aiSummary":"Cypermethrin is a synthetic pyrethroid insecticide originally developed by ICI (now part of Syngenta), a small molecule belonging to the drug class of cypermethrin. Its exact target and mechanism of action are not well-documented, but it is known to disrupt insect nervous systems. Cypermethrin is not FDA-approved for human use, and its commercial status is primarily as a pesticide. Key safety considerations include potential neurotoxicity and environmental contamination. As a pesticide, it is not intended for human therapeutic use.","approvals":[],"ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"cypermethrin","explanation":"Imagine your nerves are like a highway system, and sodium ions are like cars driving on that highway. Cypermethrin blocks the sodium ions from driving on the highway, which prevents the insect's nerves from functioning properly and ultimately kills the insect.","oneSentence":"Cypermethrin works by binding to insect voltage-gated sodium channels, preventing the normal flow of sodium ions and disrupting the insect's nervous system.","technicalDetail":"Cypermethrin binds to the insect voltage-gated sodium channel, specifically at the alpha subunit, and prevents the normal flow of sodium ions through the channel, leading to a disruption in the insect's nervous system and ultimately causing death."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/4409","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=cypermethrin","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=cypermethrin","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T10:25:33.274539","biosimilars":[],"competitors":[],"genericName":"cypermethrin","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[{"nctId":"NCT05796193","phase":"NA","title":"Net Transition Initiative: Efficacy of Two Next-generation Nets for Control of Malaria in Cote d'Ivoire","status":"ACTIVE_NOT_RECRUITING","sponsor":"London School of Hygiene and Tropical 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Rwanda","status":"COMPLETED","sponsor":"PATH","startDate":"2020-02-24","conditions":["Malaria"],"enrollment":3502,"completionDate":"2022-11-18"},{"nctId":"NCT04716387","phase":"","title":"Estimating the Malaria Prevention Impact of New Nets: Observational Analyses to Evaluate the Evidence Generated During Piloted New Net Distributions in Mozambique","status":"COMPLETED","sponsor":"PATH","startDate":"2020-08-18","conditions":["Malaria"],"enrollment":8726,"completionDate":"2022-09-30"},{"nctId":"NCT04157894","phase":"","title":"Estimating the Malaria Prevention Impact of New Nets: Observational Analyses to Evaluate the Evidence Generated During Piloted New Net Distributions in Burkina Faso","status":"COMPLETED","sponsor":"PATH","startDate":"2019-07-07","conditions":["Malaria"],"enrollment":5606,"completionDate":"2022-07-06"},{"nctId":"NCT03269006","phase":"NA","title":"Improved Case Detection and Vector Control for Visceral Leishmaniasis","status":"COMPLETED","sponsor":"International 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toxicology"},{"date":"2026 Mar 26","pmid":"41888607","title":"Investigating zeta-cypermethrin resistance stability in California Drosophila suzukii populations.","journal":"Pest management science"},{"date":"2026 Mar 26","pmid":"41887755","title":"Metabolic Assays and RNAi-Based Functional Characterization of the P450 Gene CYP6AQ1 under Environmental Stress in Apis cerana cerana.","journal":"Journal of agricultural and food chemistry"},{"date":"2026 Mar 21","pmid":"41887020","title":"Rapid assessment of pesticide toxicity in aquatic ecosystems using deep learning-based automatic duckweed counting method.","journal":"Aquatic toxicology (Amsterdam, Netherlands)"},{"date":"2026 Mar 26","pmid":"41886784","title":"Insecticide Susceptibility of Phlebotomus argentipes and Residual Action of Alpha-Cypermethrin in India: A Multicenter Study.","journal":"The American journal of tropical medicine and hygiene"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","brandName":"cypermethrin","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":true,"score":2}}