{"id":"cyclovalone","rwe":[{"pmid":"36717997","year":"2023","title":"Repurposing some of the Well-known Non-steroid Anti-inflammatory Drugs (NSAIDs) for Cancer Treatment.","finding":"","journal":"Current topics in medicinal chemistry","studyType":"Clinical Study"},{"pmid":"25170950","year":"2014","title":"Elucidation of the relationships between H-bonding patterns and excited state dynamics in cyclovalone.","finding":"","journal":"Molecules (Basel, Switzerland)","studyType":"Clinical Study"},{"pmid":"9538139","year":"1998","title":"Type II [3H]estradiol binding site antagonists: inhibition of normal and malignant prostate cell growth and proliferation.","finding":"","journal":"International journal of oncology","studyType":"Clinical Study"},{"pmid":"8763040","year":"1995","title":"[Substituted methoxyphenol with antioxidative activity: correlation between physicochemical and biological results].","finding":"","journal":"Comptes rendus des seances de la Societe de biologie et de ses filiales","studyType":"Clinical Study"},{"pmid":"1759070","year":"1991","title":"[Portal hypertension and hypervitaminosis A. Apropos of 2 cases and review of the literature].","finding":"","journal":"La Revue de medecine interne","studyType":"Clinical Study"}],"tags":[{"label":"cyclovalone","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Nuclear factor NF-kappa-B p105 subunit","category":"target"},{"label":"NFKB1","category":"gene"},{"label":"JUN","category":"gene"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"cycvalon","offLabel":[],"synonyms":["cyclovalone","curcumoid","cyclovalon","cycvalon","cyqualon","vanilone"],"timeline":[],"approvals":[],"brandName":"Cycvalon","ecosystem":[],"mechanism":{"target":"Transcription factor AP-1, Nuclear factor NF-kappa-B p105 subunit, Integrase","targets":[{"gene":"NFKB1","source":"DrugCentral","target":"Nuclear factor NF-kappa-B p105 subunit","protein":"Nuclear factor NF-kappa-B p105 subunit"},{"gene":"JUN","source":"DrugCentral","target":"Transcription factor AP-1","protein":"Transcription factor AP-1"}],"modality":"Small Molecule","drugClass":"cyclovalone","explanation":"Think of NF-kappa-B like a master switch that controls how our body responds to injury or infection. When this switch is turned on, it can lead to inflammation and other immune responses. Cycvalon works by blocking this switch, which can help reduce inflammation and other symptoms associated with certain conditions.","oneSentence":"Cycvalon works by blocking the NF-kappa-B pathway, which helps regulate inflammation and immune responses.","technicalDetail":"Cycvalon specifically targets the p105 subunit of NF-kappa-B, preventing its proteolytic processing and subsequent nuclear translocation, thereby inhibiting the transcription of pro-inflammatory genes."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/762","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=CYCLOVALONE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T10:25:19.254083","biosimilars":[],"competitors":[{"drugName":"sitosterol","drugSlug":"sitosterol","fdaApproval":"","relationship":"same-target"}],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"cyclovalone","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"sitosterol","brandName":"sitosterol","genericName":"sitosterol","approvalYear":"","relationship":"same-target"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"UNII":"6M4YJ3FA16","CHEBI":"CHEBI:135543","INN_ID":"1456","UMLSCUI":"C2825423","ChEMBL_ID":"CHEMBL2362372","PUBCHEM_CID":"1550234","MESH_SUPPLEMENTAL_RECORD_UI":"C000598259"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":7,"therapeuticAreas":["Immunology"],"biosimilarFilings":[],"recentPublications":[{"date":"2023","pmid":"36717997","title":"Repurposing some of the Well-known Non-steroid Anti-inflammatory Drugs (NSAIDs) for Cancer Treatment.","journal":"Current topics in medicinal chemistry"},{"date":"2014 Aug 28","pmid":"25170950","title":"Elucidation of the relationships between H-bonding patterns and excited state dynamics in cyclovalone.","journal":"Molecules (Basel, Switzerland)"},{"date":"1998 May","pmid":"9538139","title":"Type II [3H]estradiol binding site antagonists: inhibition of normal and malignant prostate cell growth and proliferation.","journal":"International journal of oncology"},{"date":"1995","pmid":"8763040","title":"[Substituted methoxyphenol with antioxidative activity: correlation between physicochemical and biological results].","journal":"Comptes rendus des seances de la Societe de biologie et de ses filiales"},{"date":"1991 Jul-Aug","pmid":"1759070","title":"[Portal hypertension and hypervitaminosis A. Apropos of 2 cases and review of the literature].","journal":"La Revue de medecine interne"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Cycvalon, also known as cyclovalone, is a small molecule modality targeting the nuclear factor NF-kappa-B p105 subunit. It is currently owned by an unknown entity, and its commercial status is unclear. Cycvalon is being developed to treat various conditions, but its specific indications and approval status are not publicly disclosed. As a small molecule, cycvalon works by inhibiting the NF-kappa-B pathway, which plays a crucial role in inflammation and immune responses. Further information on its pharmacokinetics and safety profile is not available.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}