{"id":"cyclosporine-0-010","safety":{"commonSideEffects":[{"rate":null,"effect":"Ocular irritation or burning"},{"rate":null,"effect":"Conjunctival erythema"},{"rate":null,"effect":"Blurred vision"},{"rate":null,"effect":"Foreign body sensation"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Cyclosporine binds to cyclophilin and inhibits calcineurin, a phosphatase required for T-cell activation and IL-2 production. In ocular tissues, this immunosuppressive effect reduces inflammation and increases tear production, making it effective for dry eye disease where immune-mediated tear gland dysfunction is a primary pathology.","oneSentence":"Cyclosporine is a calcineurin inhibitor that suppresses T-cell activation and reduces inflammatory cytokine production in the eye.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:45:31.228Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Dry eye disease (keratoconjunctivitis sicca)"}]},"trialDetails":[{"nctId":"NCT00991458","phase":"PHASE2","title":"Study of Cyclosporine in Post-LASIK Patients","status":"COMPLETED","sponsor":"Allergan","startDate":"2009-10","conditions":"Laser In Situ Keratomileusis","enrollment":621},{"nctId":"NCT00884585","phase":"PHASE3","title":"Efficacy and Safety Study of Cyclosporine 0.010% to Treat Atopic Keratoconjunctivitis","status":"COMPLETED","sponsor":"Allergan","startDate":"2009-05","conditions":"Atopic Conjunctivitis","enrollment":176}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Cyclosporine 0.010%","genericName":"Cyclosporine 0.010%","companyName":"Allergan","companyId":"allergan","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Cyclosporine is a calcineurin inhibitor that suppresses T-cell activation and reduces inflammatory cytokine production in the eye. Used for Dry eye disease (keratoconjunctivitis sicca).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}