{"id":"cyclopentolate-tropicamide-phenylephrine","safety":{"commonSideEffects":[{"rate":null,"effect":"Transient stinging or irritation"},{"rate":null,"effect":"Blurred vision"},{"rate":null,"effect":"Photophobia"},{"rate":null,"effect":"Increased intraocular pressure"},{"rate":null,"effect":"Systemic anticholinergic effects (rare)"}]},"_chembl":{"chemblId":"CHEMBL1200604","moleculeType":"Small molecule","molecularWeight":"284.36"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Cyclopentolate and tropicamide are anticholinergic agents that block muscarinic receptors in the eye, causing mydriasis (pupil dilation) and cycloplegia (paralysis of accommodation). Phenylephrine is an alpha-1 adrenergic agonist that enhances pupil dilation. Together, these agents facilitate comprehensive ophthalmic examination by maximizing pupil opening and temporarily eliminating the eye's focusing ability.","oneSentence":"This combination of three anticholinergic and sympathomimetic agents dilates the pupil and paralyzes accommodation for ophthalmic examination.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:31:29.794Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Mydriasis and cycloplegia for ophthalmic examination and diagnostic procedures"}]},"trialDetails":[{"nctId":"NCT06914063","phase":"NA","title":"Assessing Patient Comfort, Anxiety, and Satisfaction During CR Comparing Conventional Drops With ROC","status":"ACTIVE_NOT_RECRUITING","sponsor":"Superior University","startDate":"2025-03-20","conditions":"Cycloplegic Paralysis of Accommodation","enrollment":74},{"nctId":"NCT00748059","phase":"PHASE1","title":"The Pathophysiology of Orthostatic Hypotension","status":"COMPLETED","sponsor":"Vanderbilt University Medical Center","startDate":"1996-12","conditions":"Autonomic Nervous System Diseases, Orthostatic Hypotension, Dopamine Beta-Hydroxylase Deficiency","enrollment":10},{"nctId":"NCT04838665","phase":"PHASE4","title":"Changes in Vital Signs and Pupil Diameter Related to Pharmacologic Mydriasis in Premature Infants: A Randomized Double Blind Clinical Study","status":"COMPLETED","sponsor":"University of the Philippines","startDate":"2011-09-30","conditions":"Retinopathy of Prematurity","enrollment":60},{"nctId":"NCT04396301","phase":"PHASE3","title":"Effect of Intracameral Injection of Mydriatic Plus Anaesthetic Combination on Corneal Endothelial Count in Phaco","status":"COMPLETED","sponsor":"Cairo University","startDate":"2019-02-01","conditions":"Corneal Endothelial Cell Loss, Mydriasis, Cataract","enrollment":30},{"nctId":"NCT02177539","phase":"PHASE4","title":"A New More Efficient Cycloplegia Scheme","status":"UNKNOWN","sponsor":"Pontificia Universidad Catolica de Chile","startDate":"2014-05","conditions":"Refractive Errors","enrollment":30}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Cyclogyl, Mydfrin, Mydriacyl"],"phase":"marketed","status":"active","brandName":"Cyclopentolate+tropicamide+phenylephrine","genericName":"Cyclopentolate+tropicamide+phenylephrine","companyName":"Pontificia Universidad Catolica de Chile","companyId":"pontificia-universidad-catolica-de-chile","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This combination of three anticholinergic and sympathomimetic agents dilates the pupil and paralyzes accommodation for ophthalmic examination. Used for Mydriasis and cycloplegia for ophthalmic examination and diagnostic procedures.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}