{"id":"cyclopenthiazide","rwe":[{"pmid":"41379792","year":"2025","title":"Exploring the link between osteoporosis and stroke risk: An exploratory study based on 2017-2018 NHANES clinical data and bioinformatics analysis.","finding":"","journal":"PloS one","studyType":"Clinical Study"},{"pmid":"41045347","year":"2025","title":"Adduct formation by coeluting endogenous biomolecules using ESI-MS : A comprehensive study on ESI efficiency.","finding":"","journal":"Analytical and bioanalytical chemistry","studyType":"Clinical Study"},{"pmid":"38397416","year":"2024","title":"Identifying OGN as a Biomarker Covering Multiple Pathogenic Pathways for Diagnosing Heart Failure: From Machine Learning to Mechanism Interpretation.","finding":"","journal":"Biomolecules","studyType":"Clinical Study"},{"pmid":"28146143","year":"2017","title":"Combination of endovascular graft exclusion and drug therapy in AAA with hypertension or hyperglycemia.","finding":"","journal":"Minerva cardioangiologica","studyType":"Clinical Study"},{"pmid":"24869750","year":"2014","title":"Blood pressure-lowering efficacy of monotherapy with thiazide diuretics for primary hypertension.","finding":"","journal":"The Cochrane database of systematic reviews","studyType":"Clinical Study"}],"tags":[{"label":"cyclopenthiazide","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"C03AA07","category":"atc"},{"label":"Active","category":"status"},{"label":"Antihypertensive Agents","category":"pharmacology"},{"label":"Cardiovascular Agents","category":"pharmacology"},{"label":"Diuretics","category":"pharmacology"},{"label":"Membrane Transport Modulators","category":"pharmacology"},{"label":"Natriuretic Agents","category":"pharmacology"},{"label":"Sodium Chloride Symporter Inhibitors","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":["cyclopenthiazide"],"offLabel":[],"synonyms":["cyclopenthiazide"],"timeline":[],"approvals":[],"ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"cyclopenthiazide","explanation":"Think of it like a sponge: when you block the sponge's ability to absorb water, it gets too full and spills over. In the kidneys, cyclopenthiazide blocks the sponge-like cells from absorbing too much sodium, causing the body to get rid of excess sodium and water through urine.","oneSentence":"Cyclopenthiazide works by blocking the reabsorption of sodium in the kidneys, leading to increased urine production.","technicalDetail":"Cyclopenthiazide acts as a competitive inhibitor of the sodium-chloride cotransporter (NCC) in the distal convoluted tubule of the kidneys, leading to increased sodium and chloride excretion and subsequent diuresis."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/756","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=CYCLOPENTHIAZIDE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T10:24:58.934004","biosimilars":[],"competitors":[{"drugName":"bendroflumethiazide","drugSlug":"bendroflumethiazide","fdaApproval":"1959-12-07","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"hydroflumethiazide","drugSlug":"hydroflumethiazide","fdaApproval":"1959-07-22","genericCount":3,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"hydrochlorothiazide","drugSlug":"hydrochlorothiazide","fdaApproval":"1959-02-12","patentExpiry":"Jan 23, 2044","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"chlorothiazide","drugSlug":"chlorothiazide","fdaApproval":"1958-09-04","genericCount":6,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"polythiazide","drugSlug":"polythiazide","fdaApproval":"1961-09-26","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"trichlormethiazide","drugSlug":"trichlormethiazide","fdaApproval":"1960-03-09","genericCount":7,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"methylclothiazide","drugSlug":"methylclothiazide","fdaApproval":"1960-10-21","relationship":"same-class"},{"drugName":"cyclothiazide","drugSlug":"cyclothiazide","fdaApproval":"1982-06-08","patentStatus":"Unknown","relationship":"same-class"}],"genericName":"cyclopenthiazide","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"bendroflumethiazide","brandName":"bendroflumethiazide","genericName":"bendroflumethiazide","approvalYear":"1959","relationship":"same-class"},{"drugId":"hydroflumethiazide","brandName":"hydroflumethiazide","genericName":"hydroflumethiazide","approvalYear":"1959","relationship":"same-class"},{"drugId":"hydrochlorothiazide","brandName":"hydrochlorothiazide","genericName":"hydrochlorothiazide","approvalYear":"1959","relationship":"same-class"},{"drugId":"chlorothiazide","brandName":"chlorothiazide","genericName":"chlorothiazide","approvalYear":"1958","relationship":"same-class"},{"drugId":"polythiazide","brandName":"polythiazide","genericName":"polythiazide","approvalYear":"1961","relationship":"same-class"},{"drugId":"trichlormethiazide","brandName":"trichlormethiazide","genericName":"trichlormethiazide","approvalYear":"1960","relationship":"same-class"},{"drugId":"methylclothiazide","brandName":"methylclothiazide","genericName":"methylclothiazide","approvalYear":"1960","relationship":"same-class"},{"drugId":"cyclothiazide","brandName":"cyclothiazide","genericName":"cyclothiazide","approvalYear":"1982","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NUI":"N0000166948","NDDF":"002303","UNII":"VX4S2N85F5","INN_ID":"1230","RXNORM":"3000","UMLSCUI":"C0010581","ChEMBL_ID":"CHEMBL1373254","KEGG_DRUG":"D02061","DRUGBANK_ID":"DB13532","PUBCHEM_CID":"2904","SNOMEDCT_US":"317938008","IUPHAR_LIGAND_ID":"7899","MESH_DESCRIPTOR_UI":"D003518"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"pharmacokinetics":{"source":"DrugCentral","bioavailability":"99%"},"publicationCount":139,"therapeuticAreas":["Nephrology"],"atcClassification":{"source":"DrugCentral","atcCode":"C03AA07","allCodes":["C03AA07","C03AB07","C03EA07"]},"biosimilarFilings":[],"recentPublications":[{"date":"2025","pmid":"41379792","title":"Exploring the link between osteoporosis and stroke risk: An exploratory study based on 2017-2018 NHANES clinical data and bioinformatics analysis.","journal":"PloS one"},{"date":"2025 Nov","pmid":"41045347","title":"Adduct formation by coeluting endogenous biomolecules using ESI-MS : A comprehensive study on ESI efficiency.","journal":"Analytical and bioanalytical chemistry"},{"date":"2024 Feb 2","pmid":"38397416","title":"Identifying OGN as a Biomarker Covering Multiple Pathogenic Pathways for Diagnosing Heart Failure: From Machine Learning to Mechanism Interpretation.","journal":"Biomolecules"},{"date":"2017 Aug","pmid":"28146143","title":"Combination of endovascular graft exclusion and drug therapy in AAA with hypertension or hyperglycemia.","journal":"Minerva cardioangiologica"},{"date":"2014 May 29","pmid":"24869750","title":"Blood pressure-lowering efficacy of monotherapy with thiazide diuretics for primary hypertension.","journal":"The Cochrane database of systematic reviews"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","brandName":"CYCLOPENTHIAZIDE","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Cyclopenthiazide is a small molecule diuretic drug in the cyclopenthiazide class. It is used to treat hypertension and edema by increasing urine production. The commercial status of cyclopenthiazide is unknown, but it is likely available as a generic medication. Key safety considerations include potential electrolyte imbalances and dehydration. Cyclopenthiazide is a thiazide-like diuretic that works by inhibiting sodium reabsorption in the kidneys.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}