{"id":"cyclofenil","rwe":[{"pmid":"41020776","year":"2025","title":"MolDecor: Leveraging Transformers to Decorate Bioactive Molecules for Property Optimization.","finding":"","journal":"Journal of chemical information and modeling","studyType":"Clinical Study"},{"pmid":"37923147","year":"2024","title":"Molecular cloning of estrogen receptor and its function on vitellogenesis in pompano (Trachinotus ovatus).","finding":"","journal":"General and comparative endocrinology","studyType":"Clinical Study"},{"pmid":"35955769","year":"2022","title":"Distinct Roles of Estrogen Receptors in the Regulation of Vitellogenin Expression in Orange-Spotted Grouper (Epinephelus coioides).","finding":"","journal":"International journal of molecular sciences","studyType":"Clinical Study"},{"pmid":"34135380","year":"2021","title":"Improvement in aqueous solubility of achiral symmetric cyclofenil by modification to a chiral asymmetric analog.","finding":"","journal":"Scientific reports","studyType":"Clinical Study"},{"pmid":"32169784","year":"2020","title":"Development of bivalent triarylalkene- and cyclofenil-derived dual estrogen receptor antagonists and downregulators.","finding":"","journal":"European journal of medicinal chemistry","studyType":"Clinical Study"}],"tags":[{"label":"cyclofenil","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Estrogen receptor","category":"target"},{"label":"ESR1","category":"gene"},{"label":"G03GB01","category":"atc"},{"label":"Active","category":"status"},{"label":"Fertility Agents, Female","category":"pharmacology"},{"label":"Reproductive Control Agents","category":"pharmacology"}],"phase":"marketed","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=CYCLOFENIL","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T00:34:50.176595+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-20T00:34:55.266265+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=CYCLOFENIL","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-20T00:34:56.152159+00:00"},"mechanism.target_chembl":{"url":"","method":"api_direct","source":"ChEMBL mechanism: Estrogen receptor modulator","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T00:34:57.186853+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL141305/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T00:34:56.845498+00:00"}},"allNames":"fertodur","offLabel":[],"synonyms":["cyclofenil","cyclofenyl","cyclopenil","cyclophenil","cyclophenyl","ondogyne","fertodur"],"timeline":[],"approvals":[],"brandName":"Fertodur","ecosystem":[],"mechanism":{"target":"Estrogen receptor","targets":[{"gene":"ESR1","source":"DrugCentral","target":"Estrogen receptor","protein":"Estrogen receptor"}],"modality":"Small Molecule","drugClass":"cyclofenil","explanation":"","oneSentence":"","technicalDetail":"Fertodur (CYCLOFENIL) acts as a selective estrogen receptor modulator (SERM), binding to the estrogen receptor and influencing its activity, which can have downstream effects on gene expression and cellular function."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/753","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=CYCLOFENIL","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T10:24:49.717570","_validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T00:34:58.477896+00:00","fieldsConflicting":1,"overallConfidence":0.8},"biosimilars":[],"competitors":[{"drugName":"clomifene","drugSlug":"clomifene","fdaApproval":"1967-02-01","relationship":"same-class"}],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"cyclofenil","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"clomifene","brandName":"clomifene","genericName":"clomifene","approvalYear":"1967","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"NUI":"N0000166610","NDDF":"003955","UNII":"J468V64WZ1","CHEBI":"CHEBI:31446","INN_ID":"2258","RXNORM":"2983","UMLSCUI":"C0010560","chemblId":"CHEMBL141305","ChEMBL_ID":"CHEMBL141305","KEGG_DRUG":"D01281","DRUGBANK_ID":"DB13472","PUBCHEM_CID":"2898","SNOMEDCT_US":"325778008","MESH_DESCRIPTOR_UI":"D003506"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":133,"therapeuticAreas":["Other"],"atcClassification":{"source":"DrugCentral","atcCode":"G03GB01","allCodes":["G03GB01"]},"biosimilarFilings":[],"recentPublications":[{"date":"2025 Oct 13","pmid":"41020776","title":"MolDecor: Leveraging Transformers to Decorate Bioactive Molecules for Property Optimization.","journal":"Journal of chemical information and modeling"},{"date":"2024 Jan 15","pmid":"37923147","title":"Molecular cloning of estrogen receptor and its function on vitellogenesis in pompano (Trachinotus ovatus).","journal":"General and comparative endocrinology"},{"date":"2022 Aug 3","pmid":"35955769","title":"Distinct Roles of Estrogen Receptors in the Regulation of Vitellogenin Expression in Orange-Spotted Grouper (Epinephelus coioides).","journal":"International journal of molecular sciences"},{"date":"2021 Jun 16","pmid":"34135380","title":"Improvement in aqueous solubility of achiral symmetric cyclofenil by modification to a chiral asymmetric analog.","journal":"Scientific reports"},{"date":"2020 Apr 15","pmid":"32169784","title":"Development of bivalent triarylalkene- and cyclofenil-derived dual estrogen receptor antagonists and downregulators.","journal":"European journal of medicinal chemistry"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"withdrawn","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"","enrichmentLevel":3,"visitCount":1,"regulatoryByCountry":[{"country_code":"CA","regulator":"Health Canada","status":"approved","approval_date":null,"mah":"","brand_name_local":"","application_number":""},{"country_code":"US","regulator":"FDA","status":"approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null}],"trialStats":{"total":0,"withResults":0},"validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T00:34:58.477896+00:00","fieldsConflicting":1,"overallConfidence":0.8},"verificationStatus":"enriching","dataCompleteness":{"mechanism":false,"indications":false,"safety":false,"trials":false,"score":0}}