{"id":"cyclocoumarol","rwe":[{"pmid":"29407982","year":"2018","title":"New selective cyclooxygenase-2 inhibitors from cyclocoumarol: Synthesis, characterization, biological evaluation and molecular modeling.","finding":"","journal":"European journal of medicinal chemistry","studyType":"Clinical Study"},{"pmid":"10562412","year":"1999","title":"Structural forms of phenprocoumon and warfarin that are metabolized at the active site of CYP2C9.","finding":"","journal":"Archives of biochemistry and biophysics","studyType":"Clinical Study"},{"pmid":"3981543","year":"1985","title":"Stereoselective metabolism of conformational analogues of warfarin by beta-naphthoflavone-inducible cytochrome P-450.","finding":"","journal":"Journal of medicinal chemistry","studyType":"Clinical Study"}],"tags":[{"label":"cyclocoumarol","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"}],"phase":"unknown","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"cumopyran","offLabel":[],"synonyms":["cyclocumarol","cumopyrin","cyclocoumarol","methanopyranorin","methopyranorin","cumopyran"],"timeline":[],"approvals":[],"brandName":"Cumopyran","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"cyclocoumarol","explanation":"Imagine your blood as a liquid that can flow freely, but when you get hurt, it needs to clot to stop the bleeding. Cumopyran is believed to help regulate this clotting process by blocking an enzyme that helps blood cells stick together. This can help prevent excessive clotting and reduce the risk of blood clots forming.","oneSentence":"Cumopyran is thought to work by inhibiting an enzyme involved in blood clotting.","technicalDetail":"Cumopyran is likely a competitive inhibitor of the vitamin K-dependent enzyme responsible for the gamma-carboxylation of clotting factors, thereby reducing their activity and inhibiting blood coagulation."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3121","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=cyclocoumarol","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T10:24:44.599622","biosimilars":[],"competitors":[],"genericName":"cyclocoumarol","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"002088","UNII":"725P8AW50M","CHEBI":"CHEBI:135368","UMLSCUI":"C0175157","ChEMBL_ID":"CHEMBL2104144","PUBCHEM_CID":"10606","SNOMEDCT_US":"88589005","MESH_SUPPLEMENTAL_RECORD_UI":"C100102"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":3,"therapeuticAreas":["Hematology"],"biosimilarFilings":[],"recentPublications":[{"date":"2018 Feb 25","pmid":"29407982","title":"New selective cyclooxygenase-2 inhibitors from cyclocoumarol: Synthesis, characterization, biological evaluation and molecular modeling.","journal":"European journal of medicinal chemistry"},{"date":"1999 Dec 1","pmid":"10562412","title":"Structural forms of phenprocoumon and warfarin that are metabolized at the active site of CYP2C9.","journal":"Archives of biochemistry and biophysics"},{"date":"1985 Apr","pmid":"3981543","title":"Stereoselective metabolism of conformational analogues of warfarin by beta-naphthoflavone-inducible cytochrome P-450.","journal":"Journal of medicinal chemistry"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Cumopyran is a small molecule with synonyms including Cyclocoumarol and Cyclocoumarol.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}