{"id":"cyclobenzaprine-with-caffeine","safety":{"commonSideEffects":[{"rate":null,"effect":"Drowsiness"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Dry mouth"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Nervousness or jitteriness (from caffeine)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Cyclobenzaprine works as a centrally-acting skeletal muscle relaxant, likely through alpha-2 adrenergic receptor agonism and monoamine reuptake inhibition, reducing muscle spasm and tension. Caffeine is added as a stimulant to counteract the sedative effects of cyclobenzaprine, improving wakefulness and potentially enhancing analgesic efficacy through adenosine receptor antagonism.","oneSentence":"Cyclobenzaprine is a muscle relaxant that reduces muscle tension through central nervous system depression, while caffeine is a stimulant that counteracts sedation and enhances alertness.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:08:15.110Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute muscle spasm and musculoskeletal pain"}]},"trialDetails":[{"nctId":"NCT02862977","phase":"PHASE3","title":"Efficacy and Safety of the Combination of Ketoprofen and Cyclobenzaprine and Caffeine in Osteomuscular Treatment","status":"COMPLETED","sponsor":"EMS","startDate":"2017-11-10","conditions":"Musculoskeletal Pain","enrollment":414},{"nctId":"NCT01421433","phase":"PHASE3","title":"A Comparative Study Between Lysine Clonixinate+Cyclobenzaprine and Caffeine+Carisoprodol+Sodium Diclofenac+Paracetamol","status":"UNKNOWN","sponsor":"Farmoquimica S.A.","startDate":"2012-05","conditions":"Low Back Pain","enrollment":160}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Miosan Caf®"],"phase":"phase_3","status":"active","brandName":"Cyclobenzaprine with caffeine","genericName":"Cyclobenzaprine with caffeine","companyName":"EMS","companyId":"ems","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Cyclobenzaprine is a muscle relaxant that reduces muscle tension through central nervous system depression, while caffeine is a stimulant that counteracts sedation and enhances alertness. Used for Acute muscle spasm and musculoskeletal pain.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}