{"id":"cyclo-phosphamide","brandName":"cyclo phosphamide","genericName":"cyclo phosphamide","companyId":"al-azhar-university","companyName":"Al-Azhar University","phase":"marketed","status":"active","modality":"Small molecule","aliases":[],"developmentCodes":[],"firstApprovalDate":null,"firstApprovalCountry":null,"aiSummary":"Cyclophosphamide, an alkylating agent, is used in various hematological malignancies and autoimmune disorders. It is being evaluated in multiple clinical trials, including CAR T-cell therapy and stem cell transplantation. Despite no FDA label, it has off-label uses in lupus nephritis and multiple sclerosis.","enrichmentLevel":3,"visitCount":0,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Cyclophosphamide is a nitrogen mustard derivative that requires hepatic activation to form active metabolites. These metabolites covalently bind to DNA, creating inter- and intra-strand cross-links that inhibit DNA replication and transcription, leading to apoptosis. It is also immunosuppressive, depleting lymphocytes and suppressing antibody production.","oneSentence":"Cyclophosphamide is an alkylating agent that cross-links DNA strands, preventing cell division and causing cancer cell death.","_ai_confidence":"high"},"administration":{},"safety":{"commonSideEffects":[{"rate":"60-90","effect":"Myelosuppression (neutropenia, thrombocytopenia, anemia)"},{"rate":"60-90","effect":"Nausea and vomiting"},{"rate":"60-90","effect":"Alopecia"},{"rate":"5-40","effect":"Hemorrhagic cystitis"},{"rate":"variable","effect":"Infertility"},{"rate":"1-5","effect":"Secondary malignancies"},{"rate":"common","effect":"Immunosuppression and infection risk"}]},"trials":[],"indications":{"approved":[{"name":"Lymphomas (Hodgkin and non-Hodgkin)"},{"name":"Leukemias (acute and chronic)"},{"name":"Multiple myeloma"},{"name":"Breast cancer"},{"name":"Ovarian cancer"},{"name":"Severe autoimmune diseases (systemic lupus erythematosus, vasculitis)"}]},"commercial":null,"patents":[],"timeline":[],"rwe":[],"competitors":[],"ownershipHistory":[],"trialDetails":[],"genericFilers":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"labelChanges":[],"nice":null,"revenue":null,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":false,"score":3}}