{"id":"cyanocobalamin","rwe":[{"pmid":"41891996","year":"2026","title":"Thiamine and Micronutrient Deficiencies in Hospitalized Veterans Without Alcohol Use Disorder.","finding":"","journal":"Diseases (Basel, Switzerland)","studyType":"Clinical Study"},{"pmid":"41880962","year":"2026","title":"Innovative bioproduction of natural food preservative 3-hydroxypropionaldehyde by evolved Limosilactobacillus reuteri NK45.","finding":"","journal":"Food chemistry","studyType":"Clinical Study"},{"pmid":"41832801","year":"2026","title":"Population-based deprescribing strategy for proton pump inhibitors: health outcomes from a case-control study.","finding":"","journal":"Medicina clinica","studyType":"Clinical Study"},{"pmid":"41808636","year":"2026","title":"Acquired Multiple Acyl-Coenzyme A Dehydrogenase Deficiency Associated With Sertraline in Sweden-A Nationwide Population-Based Study.","finding":"","journal":"European journal of neurology","studyType":"Clinical Study"},{"pmid":"41780858","year":"2026","title":"Amelioration of postpartum hyperketonemia using amino acids, cyanocobalamin, inositol, α-lipoic acid or monensin during the transition period of dairy cows.","finding":"","journal":"Journal of dairy science","studyType":"Clinical Study"}],"_fda":{"id":"973ff5d8-ba4b-4641-a3a0-3840e4630ce3","set_id":"038fe2e7-dc16-485c-b5fb-746db7231347","openfda":{"nui":["N0000193618","M0001797","M0003153","N0000175901","M0022797","N0000175952","M0022794","N0000175951","N0000192800","N0000005657","N0000175452"],"unii":["WR1WPI7EW8","PQ6CK8PD0R","SY7Q814VUP","1C6V77QF41","P6YC3EG204","ZAD9OKH9JC","R5L488RY0Q","935E97BOY8","I38ZP9992A","KV2JZ1BI6Z"],"route":["ORAL"],"spl_id":["973ff5d8-ba4b-4641-a3a0-3840e4630ce3"],"brand_name":["PNV-DHA"],"spl_set_id":["038fe2e7-dc16-485c-b5fb-746db7231347"],"package_ndc":["42192-321-30"],"product_ndc":["42192-321"],"generic_name":["ASCORBIC ACID, CHOLECALCIFEROL, .ALPHA.-TOCOPHEROL ACETATE, DL-, PYRIDOXINE, FOLIC ACID, CYANOCOBALAMIN, CALCIUM, FERROUS FUMARATE, MAGNESIUM, DOCONEXENT"],"product_type":["HUMAN PRESCRIPTION DRUG"],"pharm_class_cs":["Ascorbic Acid [CS]","Calcium [CS]","Vitamin D [CS]","Vitamin B 12 [CS]","Vitamin B 6 [Chemical/Ingredient]","Analogs/Derivatives [Chemical/Ingredient]"],"substance_name":[".ALPHA.-TOCOPHEROL ACETATE, DL-","ASCORBIC ACID","CALCIUM","CHOLECALCIFEROL","CYANOCOBALAMIN","DOCONEXENT","FERROUS FUMARATE","FOLIC ACID","MAGNESIUM","PYRIDOXINE"],"pharm_class_epc":["Vitamin C [EPC]","Calcium [EPC]","Vitamin D [EPC]","Vitamin B12 [EPC]","Vitamin B6 Analog [EPC]"],"manufacturer_name":["Acella Pharmaceuticals, LLC"],"is_original_packager":[true]},"version":"3","warnings":["WARNING: Ingestion of more than 3 grams of omega-3 fatty acids (such as DHA) per day has been shown to have potential antithrombotic effects, including an increased bleeding time and International Normalized Ratio (INR). Administration of omega-3 fatty acids should be avoided in patients taking anticoagulants and in those known to have an inherited or acquired predisposition to bleeding."],"description":["DESCRIPTION: PNV-DHA is a prescription prenatal/postnatal multivitamin/mineral/essential fatty acid softgel. Each softgel is blue in color, opaque and imprinted with “BP 321” on one side. Supplement Facts Serving Size 1 Tablet Amount Per Serving % DV %DV for Pregnant or Lactating Women Vitamin C 85 mg 142% 142% Vitamin D 3 200 IU 50% 50% Vitamin E 10 IU 33% 33% Vitamin D 6 25 mg 1250% 1000% Folate 1 mg 250% 125% (L-methylfolate calcium 676 mcg (as Xolafin-B™ Percent Daily Values are based on a 2000 calorie diet ) molar equivalent to 600 mcg of Folic Acid) (folic acid, USP 400 mcg) Vitamin B 12 12 mcg 200% 150% Calcium 140 mg 14% 11% Iron (ferrous fumarate) 27 mg 150% 150% Magnesium 45 mg 11% 10% Docosahexaenoic Acid (DHA) (from omega-3 fatty acids) 300 mg Daily Value (DV) not established OTHER INGREDIENTS: bee’s wax, hydrogenated vegetable oil, lecithin, gelatin, glycerin, purified water, titanium dioxide, FD&C Blue #1, FD&C Red #3. INDICATIONS: PNV-DHA is a multivitamin/multimineral nutritional supplement indicated for use in the dietary management of patients with nutritional deficiencies or are in need of nutritional supplementation. CONTRAINDICATIONS: This product is contraindicated in patients with a known hypersensitivity to any of the ingredients."],"precautions":["PRECAUTIONS: Folic acid alone is improper therapy in the treatment of pernicious anemia and other megaloblastic anemias where Vitamin B12 is deficient. Folic acid in doses above 1.0 mg daily may obscure pernicious anemia in that hematologic remission can occur while neurological manifestations progress."],"how_supplied":["HOW SUPPLIED: PNV-DHA is supplied in child-resistant bottles of 30 softgels (NDC# 42192-321-30). Store at 20° - 25°C (68° - 77°F); excursions permitted to 15° - 30°C (59° - 86°F) [See USP Controlled Room Temperature.]"],"boxed_warning":["WARNING: Accidental overdose of iron-containing products is a leading cause of fatal poisoning in children under 6. Keep this product out of reach of children. In case of accidental overdose, call a doctor or poison control center immediately."],"effective_time":"20240115","adverse_reactions":["ADVERSE REACTIONS: Allergic sensitization has been reported following both oral and parenteral administration of folic acid."],"contraindications":["CONTRAINDICATIONS: This product is contraindicated in patients with a known hypersensitivity to any of the ingredients."],"description_table":["
Supplement Facts
Serving Size 1 Tablet
Amount Per Serving % DV %DV for Pregnant or Lactating Women
Vitamin C85 mg142%142%
Vitamin D 3200 IU50%50%
Vitamin E10 IU33%33%
Vitamin D 625 mg1250%1000%
Folate1 mg250%125%
(L-methylfolate calcium 676 mcg (as Xolafin-B™ Percent Daily Values are based on a 2000 calorie diet) molar equivalent to 600 mcg of Folic Acid)
(folic acid, USP 400 mcg)
Vitamin B 1212 mcg200%150%
Calcium140 mg14%11%
Iron (ferrous fumarate)27 mg150%150%
Magnesium45 mg11%10%
Docosahexaenoic Acid (DHA) (from omega-3 fatty acids) 300 mgDaily Value (DV) not established
"],"inactive_ingredient":["OTHER INGREDIENTS: bee’s wax, hydrogenated vegetable oil, lecithin, gelatin, glycerin, purified water, titanium dioxide, FD&C Blue #1, FD&C Red #3."],"indications_and_usage":["INDICATIONS: PNV-DHA is a multivitamin/multimineral nutritional supplement indicated for use in the dietary management of patients with nutritional deficiencies or are in need of nutritional supplementation."],"spl_unclassified_section":["Rx Only","KEEP THIS AND ALL MEDICATIONS OUT OF THE REACH OF CHILDREN.","All prescription substitutions and/or recommendations using this product shall be made subject to state and federal statutes as applicable. Please note: this is not an Orange Book product and has not been subjected to FDA therapeutic equivalency or other equivalency testing. No representation is made as to generic status or bioequivalency. Each person recommending a prescription substitution using this product shall make such recommendations based on each such person’s professional opinion and knowledge, upon evaluating the active ingredients, excipients, inactive ingredients and chemical information provided herein.","MANUFACTURED FOR: Acella Pharmaceuticals, LLC 9005 Westside Parkway Alpharetta, GA 30009 1-800-541-4802 Rev. 04/10v6 *Xolafin-B™ is a trademark of Acella Pharmaceuticals, LLC"],"dosage_and_administration":["DOSAGE AND ADMINISTRATION: Before, during and/or after pregnancy, one softgel daily or as directed by a physician."],"spl_product_data_elements":["PNV-DHA ascorbic acid, cholecalciferol, .alpha.-tocopherol acetate, dl-, pyridoxine, folic acid, cyanocobalamin, calcium, ferrous fumarate, magnesium, doconexent CARNAUBA WAX CORN OIL LECITHIN, SOYBEAN GELATIN GLYCERIN WATER TITANIUM DIOXIDE FD&C BLUE NO. 1 FD&C RED NO. 3 ASCORBIC ACID ASCORBIC ACID CHOLECALCIFEROL CHOLECALCIFEROL .ALPHA.-TOCOPHEROL ACETATE, DL- .ALPHA.-TOCOPHEROL, DL- PYRIDOXINE PYRIDOXINE FOLIC ACID FOLIC ACID CYANOCOBALAMIN CYANOCOBALAMIN CALCIUM CALCIUM FERROUS FUMARATE FERROUS CATION MAGNESIUM MAGNESIUM DOCONEXENT DOCONEXENT BP;321"],"package_label_principal_display_panel":["PRINCIPAL DISPLAY PANEL - 30 Softgel Tablets NDC 42192-321-30 PNV-DHA Rx Prenatal Vitamin and DHA Rx Only 30 Softgels Acella PHARMACEUTICALS, LLC PRINCIPAL DISPLAY PANEL - Film Coated Tablets"]},"tags":[{"label":"Vitamin B12","category":"class"},{"label":"Peptide","category":"modality"},{"label":"Cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrial","category":"target"},{"label":"MMAB","category":"gene"},{"label":"MTR","category":"gene"},{"label":"MTRR","category":"gene"},{"label":"B03AE01","category":"atc"},{"label":"Oral","category":"route"},{"label":"Capsule","category":"form"},{"label":"Off-Patent","category":"patent"},{"label":"Generic Available","category":"availability"},{"label":"Established","category":"status"},{"label":"Cobalamin deficiency","category":"indication"},{"label":"Iron deficiency anemia","category":"indication"},{"label":"Megaloblastic anemia due to folate deficiency","category":"indication"},{"label":"Pernicious anemia","category":"indication"},{"label":"Prevention of Vitamin B12 Deficiency","category":"indication"},{"label":"Vitamin Deficiency Prevention","category":"indication"},{"label":"Approved 1940s","category":"decade"},{"label":"Micronutrients","category":"pharmacology"},{"label":"Vitamin B Complex","category":"pharmacology"},{"label":"Vitamins","category":"pharmacology"}],"phase":"marketed","safety":{"boxedWarnings":["WARNING: Accidental overdose of iron-containing products is a leading cause of fatal poisoning in children under 6. Keep this product out of reach of children. In case of accidental overdose, call a doctor or poison control center immediately."],"safetySignals":[{"date":"","signal":"FATIGUE","source":"FDA FAERS","actionTaken":"3196 reports"},{"date":"","signal":"NAUSEA","source":"FDA FAERS","actionTaken":"2649 reports"},{"date":"","signal":"HEADACHE","source":"FDA FAERS","actionTaken":"2310 reports"},{"date":"","signal":"OFF LABEL USE","source":"FDA FAERS","actionTaken":"2303 reports"},{"date":"","signal":"PAIN","source":"FDA FAERS","actionTaken":"2180 reports"},{"date":"","signal":"DIARRHOEA","source":"FDA FAERS","actionTaken":"2170 reports"},{"date":"","signal":"DRUG INEFFECTIVE","source":"FDA FAERS","actionTaken":"2077 reports"},{"date":"","signal":"DYSPNOEA","source":"FDA FAERS","actionTaken":"2060 reports"},{"date":"","signal":"ASTHENIA","source":"FDA FAERS","actionTaken":"1726 reports"},{"date":"","signal":"VOMITING","source":"FDA FAERS","actionTaken":"1718 reports"}],"drugInteractions":[{"url":"/drug/esomeprazole","drug":"esomeprazole","action":"Monitor closely","effect":"May interact with Esomeprazole","source":"DrugCentral","drugSlug":"esomeprazole"},{"url":"/drug/lansoprazole","drug":"lansoprazole","action":"Monitor closely","effect":"May interact with Lansoprazole","source":"DrugCentral","drugSlug":"lansoprazole"},{"url":"/drug/omeprazole","drug":"omeprazole","action":"Monitor closely","effect":"May interact with Omeprazole","source":"DrugCentral","drugSlug":"omeprazole"},{"url":"/drug/pantoprazole","drug":"pantoprazole","action":"Monitor closely","effect":"May interact with Pantoprazole","source":"DrugCentral","drugSlug":"pantoprazole"},{"url":"/drug/rabeprazole","drug":"rabeprazole","action":"Monitor closely","effect":"May interact with Rabeprazole","source":"DrugCentral","drugSlug":"rabeprazole"}],"commonSideEffects":[{"effect":"Pulmonary edema","drugRate":"reported","severity":"unknown"},{"effect":"Congestive heart failure","drugRate":"reported","severity":"unknown"},{"effect":"Peripheral vascular thrombosis","drugRate":"reported","severity":"unknown"},{"effect":"Anaphylactic shock","drugRate":"reported","severity":"unknown"},{"effect":"Death","drugRate":"reported","severity":"unknown"},{"effect":"Polycythemia vera","drugRate":"reported","severity":"unknown"},{"effect":"Mild transient diarrhea","drugRate":"reported","severity":"unknown"},{"effect":"Itching","drugRate":"reported","severity":"unknown"},{"effect":"Transitory exanthema","drugRate":"reported","severity":"unknown"},{"effect":"Feeling of swelling of entire body","drugRate":"reported","severity":"unknown"}],"specialPopulations":{"Pregnancy":"Teratogenic Effects. Pregnancy Category C: Adequate and well-controlled studies have not been done in pregnant women. However, vitamin B12 is an essential vitamin and requirements are increased during pregnancy. Amounts of vitamin B12 that are recommended by the Food and Nutrition Board, National Academy of Science-National Research Council for pregnant women (4 mcg daily) should be consumed during pregnancy.","Paediatric use":"Intake in children should be in the amount (0.5 to mcg daily) recommended by the Food and Nutrition Board, National Academy of Science-National Research Council."}},"trials":[],"aliases":[],"patents":[],"pricing":[{"market":"United States","source":"CMS National Average Drug Acquisition Cost (NADAC)","asOfDate":"2024-01-03","unitCost":"$2.4691/ML","priceType":"NADAC","sourceUrl":"https://data.medicaid.gov/dataset/4j6z-xnwq","annualCost":"$889","description":"CYANOCOBALAMIN 1,000 MCG/ML VL","retrievedDate":"2026-04-07"}],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=CYANOCOBALAMIN","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T00:33:42.062422+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-20T00:33:48.213112+00:00"},"regulatory.us":{"url":"","method":"api_direct","source":"FDA Drugs@FDA","rawText":"","confidence":1,"sourceType":"fda_drugsfda","retrievedAt":"2026-04-20T00:33:41.193707+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=CYANOCOBALAMIN","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-20T00:33:48.798056+00:00"},"mechanism.drugClass":{"url":"https://api.fda.gov/drug/label.json","method":"deterministic","source":"FDA Label (EPC)","rawText":"","confidence":1,"sourceType":"fda_label","retrievedAt":"2026-04-20T00:33:37.098427+00:00"},"administration.route":{"url":"","method":"deterministic","source":"FDA Label","rawText":"","confidence":1,"sourceType":"fda_label","retrievedAt":"2026-04-20T00:33:37.098468+00:00"},"safety.boxedWarnings":{"url":"","method":"deterministic","source":"FDA Label (boxed_warning)","rawText":"WARNING: Accidental overdose of iron-containing products is a leading cause of fatal poisoning in children under 6. Keep this product out of reach of children. In case of accidental overdose, call a doctor or poison control center immediately.","confidence":1,"sourceType":"fda_label","retrievedAt":"2026-04-20T00:33:37.098475+00:00"},"safety.safetySignals":{"url":"https://api.fda.gov/drug/event.json","method":"api_direct","source":"FDA FAERS","rawText":"","confidence":1,"sourceType":"fda_faers","retrievedAt":"2026-04-20T00:33:50.350700+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL2110563/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T00:33:49.521478+00:00"}},"allNames":"rubramin pc","offLabel":[],"synonyms":["cyanocobalamin","vitamin B12","cobamin","cyanocobalamine"],"timeline":[{"date":"1949-09-15","type":"positive","source":"DrugCentral","milestone":"FDA approval"},{"date":"1996-11-05","type":"positive","source":"FDA Orange Book","milestone":"Nascobal approved — 0.5MG/INH"},{"date":"2005-01-31","type":"positive","source":"FDA Orange Book","milestone":"Nascobal approved — 0.5MG/SPRAY **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**"},{"date":"2007-07-27","type":"positive","source":"FDA Orange Book","milestone":"Calomist approved — 25MCG/SPRAY"}],"approvals":[{"date":"1949-09-15","orphan":false,"company":"","regulator":"FDA"}],"brandName":"Rubramin Pc","ecosystem":[{"indication":"Cobalamin deficiency","otherDrugs":[{"name":"cobalamin","slug":"cobalamin","company":""},{"name":"hydroxocobalamin","slug":"hydroxocobalamin","company":"Watson Labs"},{"name":"thiamine","slug":"thiamine","company":"Hospira"}],"globalPrevalence":null},{"indication":"Iron deficiency anemia","otherDrugs":[{"name":"docusate sodium","slug":"docusate-sodium","company":""},{"name":"ferric carboxymaltose","slug":"ferric-carboxymaltose","company":"Luitpold"},{"name":"ferric citrate","slug":"ferric-citrate","company":"Keryx Biopharms"},{"name":"ferric derisomaltose","slug":"ferric-derisomaltose","company":"Pharmacosmos As"}],"globalPrevalence":null},{"indication":"Megaloblastic anemia due to folate deficiency","otherDrugs":[{"name":"docusate sodium","slug":"docusate-sodium","company":""},{"name":"ferrous fumarate","slug":"ferrous-fumarate","company":"Gd Searle Llc"},{"name":"ferrous sulfate","slug":"ferrous-sulfate","company":"Lederle"},{"name":"folic acid","slug":"folic-acid","company":"Lederle"}],"globalPrevalence":null},{"indication":"Pernicious anemia","otherDrugs":[{"name":"cobalamin","slug":"cobalamin","company":""},{"name":"hydroxocobalamin","slug":"hydroxocobalamin","company":"Watson Labs"},{"name":"thiamine","slug":"thiamine","company":"Hospira"}],"globalPrevalence":null},{"indication":"Prevention of Vitamin B12 Deficiency","otherDrugs":[{"name":"cobalamin","slug":"cobalamin","company":""},{"name":"cobamamide","slug":"cobamamide","company":""},{"name":"folic acid","slug":"folic-acid","company":"Lederle"},{"name":"hydroxocobalamin","slug":"hydroxocobalamin","company":"Watson Labs"}],"globalPrevalence":null},{"indication":"Vitamin Deficiency Prevention","otherDrugs":[{"name":"ergocalciferol","slug":"ergocalciferol","company":"Sanofi Aventis Us"},{"name":"ferrous sulfate","slug":"ferrous-sulfate","company":"Lederle"},{"name":"folic acid","slug":"folic-acid","company":"Lederle"},{"name":"retinol","slug":"retinol","company":"Hospira"}],"globalPrevalence":null},{"indication":"Vitamin deficiency","otherDrugs":[{"name":"colecalciferol","slug":"colecalciferol","company":"Sandoz"},{"name":"ergocalciferol","slug":"ergocalciferol","company":"Sanofi Aventis Us"},{"name":"ferrous sulfate","slug":"ferrous-sulfate","company":"Lederle"},{"name":"folic acid","slug":"folic-acid","company":"Lederle"}],"globalPrevalence":null}],"mechanism":{"target":"Cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrial","novelty":"Follow-on","targets":[{"gene":"MMAB","source":"DrugCentral","target":"Cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrial","protein":"Cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrial"},{"gene":"MTR","source":"DrugCentral","target":"Methionine synthase","protein":"Methionine synthase"},{"gene":"MTRR","source":"DrugCentral","target":"Methionine synthase reductase","protein":"Methionine synthase reductase"},{"gene":"MMAA","source":"DrugCentral","target":"Methylmalonic aciduria type A protein, mitochondrial","protein":"Methylmalonic aciduria type A protein, mitochondrial"},{"gene":"AMN","source":"DrugCentral","target":"Protein amnionless","protein":"Protein amnionless"},{"gene":"TCN1","source":"DrugCentral","target":"Transcobalamin-1","protein":"Transcobalamin-1"},{"gene":"TCN2","source":"DrugCentral","target":"Transcobalamin-2","protein":"Transcobalamin-2"}],"modality":"Small Molecule","drugClass":"Vitamin C [EPC]","explanation":"","oneSentence":"","technicalDetail":"Rubramin PC (Cyanocobalamin) acts as a cofactor for the enzyme cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrial, which is involved in the synthesis of methionine and the maintenance of homocysteine levels in the body."},"commercial":{"launchDate":"1949","_launchSource":"DrugCentral (FDA 1949-09-15, )"},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/4196","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=CYANOCOBALAMIN","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=CYANOCOBALAMIN","fields":["publications"],"source":"PubMed/NCBI"},{"id":4,"url":"https://www.fda.gov/drugs/drug-approvals-and-databases/orange-book-data-files","fields":["patents","exclusivity","genericManufacturers"],"source":"FDA Orange Book"}],"_enrichedAt":"2026-03-30T10:20:57.260140","_validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T00:33:55.390217+00:00","fieldsConflicting":1,"overallConfidence":0.8},"biosimilars":[],"competitors":[{"drugName":"folic acid","drugSlug":"folic-acid","fdaApproval":"1946-08-13","genericCount":36,"patentStatus":"Off-patent — generic 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acidemia","source":"DrugCentral","drugName":"CYANOCOBALAMIN","evidenceCount":272,"evidenceLevel":"strong"}],"pipeline":[]},"currentOwner":"Bristol Myers Squibb","drugCategory":"established","labelChanges":[],"patentStatus":"Off-patent — no active Orange Book patents","relatedDrugs":[{"drugId":"folic-acid","brandName":"folic acid","genericName":"folic acid","approvalYear":"1946","relationship":"same-class"},{"drugId":"iron","brandName":"iron","genericName":"iron","approvalYear":"","relationship":"same-class"}],"trialDetails":[{"nctId":"NCT05385042","phase":"NA","title":"Iron and Immune Response to Vaccine (IRONMUM)","status":"COMPLETED","sponsor":"University of Oxford","startDate":"2022-06-18","conditions":["Pregnancy Related"],"enrollment":171,"completionDate":"2025-07-22"},{"nctId":"NCT00078078","phase":"","title":"Clinical and Laboratory Study of Methylmalonic Acidemia","status":"RECRUITING","sponsor":"National Human Genome Research Institute (NHGRI)","startDate":"2004-06-07","conditions":["Organic Acidemia","Methylmalonic Acidemia","Inborn Errors of Metabolism"],"enrollment":2275,"completionDate":""},{"nctId":"NCT07487610","phase":"","title":"Relationship Between Neuropathic Pain and Geriatric Assessment Parameters in Patients Aged 80 Years and Older","status":"RECRUITING","sponsor":"Sultan 1. Murat State Hospital","startDate":"2026-03-17","conditions":["Neuropathic Pain","Old Age; Debility","Pain"],"enrollment":450,"completionDate":"2026-06-30"},{"nctId":"NCT07486141","phase":"NA","title":"Effect of Vitamin D and Folic Acid on Mild Cognitive Impairment","status":"ACTIVE_NOT_RECRUITING","sponsor":"Capital Medical University","startDate":"2024-11-01","conditions":["Mild Cognitive Impairment"],"enrollment":380,"completionDate":"2026-06"},{"nctId":"NCT06969716","phase":"","title":"Frequency of Fibromyalgia Syndrome in Elderly Patients Aged 80 and Above and Its Relationship With Geriatric Parameters","status":"COMPLETED","sponsor":"Sultan 1. 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