{"id":"cyamemazine","rwe":[{"pmid":"41708357","year":"2026","title":"Coprescription of antipsychotics and benzodiazepines at hospital discharge.","finding":"","journal":"L'Encephale","studyType":"Clinical Study"},{"pmid":"41428068","year":"2026","title":"Misuse of cocaine in a patient with cluster headache: A clinico-biological case report.","finding":"","journal":"Annales de biologie clinique","studyType":"Clinical Study"},{"pmid":"40787077","year":"2025","title":"Nonclassical Crystallization of the L‑Tartrate Salt of Cyamemazine.","finding":"","journal":"Crystal growth & design","studyType":"Clinical Study"},{"pmid":"40090830","year":"2025","title":"Clinical profiles, treatment adherence, and quality of life in patients with severe mental disorders treated with cyamemazine: A real-world observational study.","finding":"","journal":"L'Encephale","studyType":"Clinical Study"},{"pmid":"39078300","year":"2024","title":"Case 327: Exogenous Lipoid Pneumonia.","finding":"","journal":"Radiology","studyType":"Clinical Study"}],"tags":[{"label":"cyamemazine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"5-hydroxytryptamine receptor 2A","category":"target"},{"label":"HTR2A","category":"gene"},{"label":"DRD3","category":"gene"},{"label":"DRD1","category":"gene"},{"label":"N05AA06","category":"atc"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{"safetySignals":[{"llr":2553.175,"date":"","count":836,"signal":"Coma","source":"DrugCentral FAERS","actionTaken":"Reported 836 times (LLR=2553)"},{"llr":1671.66,"date":"","count":409,"signal":"Poisoning deliberate","source":"DrugCentral FAERS","actionTaken":"Reported 409 times (LLR=1672)"},{"llr":633.776,"date":"","count":349,"signal":"Drug abuse","source":"DrugCentral FAERS","actionTaken":"Reported 349 times (LLR=634)"},{"llr":586.045,"date":"","count":408,"signal":"Somnolence","source":"DrugCentral FAERS","actionTaken":"Reported 408 times (LLR=586)"},{"llr":491.146,"date":"","count":152,"signal":"Miosis","source":"DrugCentral FAERS","actionTaken":"Reported 152 times (LLR=491)"},{"llr":435.355,"date":"","count":413,"signal":"Toxicity to various agents","source":"DrugCentral FAERS","actionTaken":"Reported 413 times (LLR=435)"},{"llr":332.621,"date":"","count":155,"signal":"Altered state of consciousness","source":"DrugCentral FAERS","actionTaken":"Reported 155 times (LLR=333)"},{"llr":313.952,"date":"","count":146,"signal":"Hepatocellular injury","source":"DrugCentral FAERS","actionTaken":"Reported 146 times (LLR=314)"},{"llr":300.341,"date":"","count":99,"signal":"Asphyxia","source":"DrugCentral FAERS","actionTaken":"Reported 99 times (LLR=300)"},{"llr":287.556,"date":"","count":187,"signal":"Intentional overdose","source":"DrugCentral FAERS","actionTaken":"Reported 187 times (LLR=288)"},{"llr":260.496,"date":"","count":164,"signal":"Suicide attempt","source":"DrugCentral FAERS","actionTaken":"Reported 164 times (LLR=260)"},{"llr":250.195,"date":"","count":166,"signal":"Rhabdomyolysis","source":"DrugCentral FAERS","actionTaken":"Reported 166 times (LLR=250)"},{"llr":240.051,"date":"","count":101,"signal":"Extrapyramidal disorder","source":"DrugCentral FAERS","actionTaken":"Reported 101 times (LLR=240)"},{"llr":185.118,"date":"","count":276,"signal":"Hypotension","source":"DrugCentral FAERS","actionTaken":"Reported 276 times (LLR=185)"},{"llr":176.598,"date":"","count":74,"signal":"Mydriasis","source":"DrugCentral FAERS","actionTaken":"Reported 74 times (LLR=177)"}],"commonSideEffects":[{"effect":"Coma","drugRate":"LLR 2553","severity":"serious"},{"effect":"Poisoning deliberate","drugRate":"LLR 1672","severity":"serious"},{"effect":"Drug abuse","drugRate":"LLR 634","severity":"serious"},{"effect":"Somnolence","drugRate":"LLR 586","severity":"serious"},{"effect":"Miosis","drugRate":"LLR 491","severity":"common"},{"effect":"Toxicity to various agents","drugRate":"LLR 435","severity":"common"},{"effect":"Altered state of consciousness","drugRate":"LLR 333","severity":"common"},{"effect":"Hepatocellular injury","drugRate":"LLR 314","severity":"common"},{"effect":"Asphyxia","drugRate":"LLR 300","severity":"common"},{"effect":"Suicide attempt","drugRate":"LLR 260","severity":"common"},{"effect":"Rhabdomyolysis","drugRate":"LLR 250","severity":"common"},{"effect":"Extrapyramidal disorder","drugRate":"LLR 240","severity":"common"},{"effect":"Hypotension","drugRate":"LLR 185","severity":"common"},{"effect":"Mydriasis","drugRate":"LLR 177","severity":"common"}]},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"ciamatil","offLabel":[],"synonyms":["cyamemazine","ciamatil","cianatil","cyamemazin","cyamepromazine","cyamepromezine"],"timeline":[],"approvals":[],"brandName":"Ciamatil","ecosystem":[],"mechanism":{"target":"5-hydroxytryptamine receptor 1A, 5-hydroxytryptamine receptor 2A, 5-hydroxytryptamine receptor 2C","targets":[{"gene":"HTR2A","source":"DrugCentral","target":"5-hydroxytryptamine receptor 2A","protein":"5-hydroxytryptamine receptor 2A"},{"gene":"DRD3","source":"DrugCentral","target":"D(3) dopamine receptor","protein":"D(3) dopamine receptor"},{"gene":"DRD1","source":"DrugCentral","target":"D(1A) dopamine receptor","protein":"D(1A) dopamine receptor"},{"gene":"DRD2","source":"DrugCentral","target":"D(2) dopamine receptor","protein":"D(2) dopamine receptor"},{"gene":"CHRM4","source":"DrugCentral","target":"Muscarinic acetylcholine receptor M4","protein":"Muscarinic acetylcholine receptor M4"},{"gene":"HTR2C","source":"DrugCentral","target":"5-hydroxytryptamine receptor 2C","protein":"5-hydroxytryptamine receptor 2C"},{"gene":"CHRM1","source":"DrugCentral","target":"Muscarinic acetylcholine receptor M1","protein":"Muscarinic acetylcholine receptor M1"},{"gene":"CHRM3","source":"DrugCentral","target":"Muscarinic acetylcholine receptor M3","protein":"Muscarinic acetylcholine receptor M3"},{"gene":"CHRM5","source":"DrugCentral","target":"Muscarinic acetylcholine receptor M5","protein":"Muscarinic acetylcholine receptor M5"},{"gene":"CHRM2","source":"DrugCentral","target":"Muscarinic acetylcholine receptor M2","protein":"Muscarinic acetylcholine receptor M2"}],"modality":"Small Molecule","drugClass":"cyamemazine","explanation":"Imagine your brain has a 'volume control' for emotions and thoughts. The 5-HT2A receptor is like a dial that can turn up or down the volume of these feelings. By blocking this receptor, Ciamatil helps reduce excessive or overwhelming emotions, which can be beneficial for people with certain psychiatric conditions.","oneSentence":"Ciamatil works by blocking the 5-HT2A receptor, a protein that helps regulate mood and other psychological processes.","technicalDetail":"Ciamatil exerts its effects by competitively antagonizing the 5-HT2A receptor, a subtype of serotonin receptor, which is involved in the regulation of mood, cognition, and other psychological processes."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/746","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=CYAMEMAZINE","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=CYAMEMAZINE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T10:23:43.601945","biosimilars":[],"competitors":[{"drugName":"chlorpromazine","drugSlug":"chlorpromazine","fdaApproval":"1957-09-18","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"levomepromazine","drugSlug":"levomepromazine","fdaApproval":"","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"promazine","drugSlug":"promazine","fdaApproval":"1956-04-13","genericCount":1,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"acepromazine","drugSlug":"acepromazine","fdaApproval":"","relationship":"same-class"},{"drugName":"triflupromazine","drugSlug":"triflupromazine","fdaApproval":"1957-09-16","patentStatus":"Unknown","relationship":"same-class"}],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"cyamemazine","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"chlorpromazine","brandName":"chlorpromazine","genericName":"chlorpromazine","approvalYear":"1957","relationship":"same-class"},{"drugId":"levomepromazine","brandName":"levomepromazine","genericName":"levomepromazine","approvalYear":"","relationship":"same-class"},{"drugId":"promazine","brandName":"promazine","genericName":"promazine","approvalYear":"1956","relationship":"same-class"},{"drugId":"acepromazine","brandName":"acepromazine","genericName":"acepromazine","approvalYear":"","relationship":"same-class"},{"drugId":"triflupromazine","brandName":"triflupromazine","genericName":"triflupromazine","approvalYear":"1957","relationship":"same-class"}],"trialDetails":[{"nctId":"NCT01557712","phase":"PHASE3","title":"Estimate the Efficiency of the Association of an Injection of Ketamine and the Venlafaxine in the Severe Major Depressive Disorder for Six Weeks","status":"COMPLETED","sponsor":"University Hospital, Grenoble","startDate":"2012-03","conditions":["Major Depressive Disorder"],"enrollment":25,"completionDate":"2017-01"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"NDDF":"005507","UNII":"A2JGV5CNU4","CHEBI":"CHEBI:135379","INN_ID":"1148","RXNORM":"21877","UMLSCUI":"C0056643","ChEMBL_ID":"CHEMBL2104153","KEGG_DRUG":"D07307","DRUGBANK_ID":"DB09000","PUBCHEM_CID":"62865","IUPHAR_LIGAND_ID":"84","MESH_SUPPLEMENTAL_RECORD_UI":"C028457"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":95,"therapeuticAreas":["Other"],"atcClassification":{"source":"DrugCentral","atcCode":"N05AA06","allCodes":["N05AA06"]},"biosimilarFilings":[],"recentPublications":[{"date":"2026 Feb 17","pmid":"41708357","title":"Coprescription of antipsychotics and benzodiazepines at hospital discharge.","journal":"L'Encephale"},{"date":"2026 Jan 20","pmid":"41428068","title":"Misuse of cocaine in a patient with cluster headache: A clinico-biological case report.","journal":"Annales de biologie clinique"},{"date":"2025 Aug 6","pmid":"40787077","title":"Nonclassical Crystallization of the L‑Tartrate Salt of Cyamemazine.","journal":"Crystal growth & design"},{"date":"2025 Dec","pmid":"40090830","title":"Clinical profiles, treatment adherence, and quality of life in patients with severe mental disorders treated with cyamemazine: A real-world observational study.","journal":"L'Encephale"},{"date":"2024 Jul","pmid":"39078300","title":"Case 327: Exogenous Lipoid Pneumonia.","journal":"Radiology"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Ciamatil is a small molecule modality. It is also known by other names, including CIAMEMAZINA, CYAMEMAZINE, FL-6229, RP 7204, and RP-7204.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":false,"safety":true,"trials":true,"score":3}}