{"id":"custodiol-htk-soln","safety":{"commonSideEffects":[]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Custodiol HTK (histidine-tryptophan-ketoglutarate solution) is a specialized extracellular-type preservation fluid designed for hypothermic organ storage. It contains a balanced composition of electrolytes, amino acids (histidine and tryptophan), and ketoglutarate that reduces intracellular edema, maintains cellular metabolism, and protects against reperfusion injury during the cold ischemic period before organ transplantation.","oneSentence":"Custodiol HTK is an organ preservation solution that maintains cellular viability during cold storage by providing essential electrolytes, buffers, and metabolic substrates while minimizing ischemic injury.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:31:37.954Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Cold preservation of donor organs (heart, kidney, liver, pancreas) for transplantation"}]},"trialDetails":[{"nctId":"NCT06530641","phase":"PHASE4","title":"Evaluation of Clinical Impact of the Type of Cardioplegia Used in the Patient Undergoing Major Cardiac Surgery.","status":"RECRUITING","sponsor":"Lourdes Montero Cruces","startDate":"2024-12-01","conditions":"Cardiac Surgery, Cardioplegia, Heart Arrest","enrollment":600}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Custodiol HTK solution. ACT: K944866"],"phase":"marketed","status":"active","brandName":"Custodiol Htk Soln","genericName":"Custodiol Htk Soln","companyName":"Lourdes Montero Cruces","companyId":"lourdes-montero-cruces","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Custodiol HTK is an organ preservation solution that maintains cellular viability during cold storage by providing essential electrolytes, buffers, and metabolic substrates while minimizing ischemic injury. Used for Cold preservation of donor organs (heart, kidney, liver, pancreas) for transplantation.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":true,"score":3}}