{"id":"curodont-d-senz","safety":{"commonSideEffects":[{"rate":null,"effect":"Tooth sensitivity"},{"rate":null,"effect":"Local irritation at application site"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The drug contains a synthetic peptide (P 11-4) that self-assembles into a three-dimensional scaffold within demineralized dentin lesions. This scaffold guides the deposition of hydroxyapatite crystals and promotes the remineralization of carious lesions, effectively arresting or reversing early-stage dental caries without requiring traditional drilling and filling.","oneSentence":"Curodont D'senz is a self-assembling peptide that promotes dentin remineralization and repair by mimicking the natural extracellular matrix structure.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:31:35.932Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Treatment of early-stage dentin caries lesions (arrested caries management)"}]},"trialDetails":[{"nctId":"NCT05122312","phase":"PHASE4","title":"Comparative Study on the Efficacy of OliNano SEAL and Curodont D' Senz in Treatment of Dentin Hypersensitivity","status":"COMPLETED","sponsor":"Al-Azhar University","startDate":"2020-04-20","conditions":"Dentin Hypersensitivity","enrollment":70}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Self assembling peptide containing desensitizing agent"],"phase":"marketed","status":"active","brandName":"Curodont D'senz","genericName":"Curodont D'senz","companyName":"Al-Azhar University","companyId":"al-azhar-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Curodont D'senz is a treatment for dentin hypersensitivity, as indicated by a clinical trial on ClinicalTrials.gov. The mechanism of Curodont D'senz is not specified in the provided facts, but it is being compared to Olinanoseal in a study on its efficacy for treating dentin hypersensitivity.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}