{"id":"curare-atracurium","safety":{"commonSideEffects":[{"rate":null,"effect":"Histamine release (flushing, hypotension, tachycardia)"},{"rate":null,"effect":"Prolonged neuromuscular blockade"},{"rate":null,"effect":"Anaphylaxis"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Atracurium binds to nicotinic acetylcholine receptors at the motor end plate, preventing acetylcholine from binding and triggering muscle contraction. This results in flaccid paralysis of skeletal muscles. Atracurium is metabolized by Hofmann elimination (temperature and pH-dependent degradation) and ester hydrolysis, making it suitable for patients with hepatic or renal impairment.","oneSentence":"Atracurium is a non-depolarizing neuromuscular blocking agent that competitively antagonizes acetylcholine at the neuromuscular junction, causing paralysis.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:40:09.730Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Skeletal muscle relaxation during anesthesia and mechanical ventilation"},{"name":"Facilitation of endotracheal intubation"}]},"trialDetails":[{"nctId":"NCT04459533","phase":"","title":"Sparing in Neuromuscular Blockade in COVID 19 ICU","status":"COMPLETED","sponsor":"Hospices Civils de Lyon","startDate":"2020-06-01","conditions":"Neuromuscular Blockade, Human Characteristics, Complication of Medical Care","enrollment":250},{"nctId":"NCT03701256","phase":"PHASE4","title":"Bilateral Transversus Abdominis Plane Block Versus Atracurium During Laparoscopic Gynecology Procedures.","status":"COMPLETED","sponsor":"University Tunis El Manar","startDate":"2015-02-01","conditions":"Neuromuscular Blockade, Regional Anesthesia","enrollment":100},{"nctId":"NCT02404142","phase":"PHASE4","title":"Curarisation and Intubation Conditions During Videolaryngoscopy With Glidescope Titanium","status":"COMPLETED","sponsor":"CHU de Reims","startDate":"2015-02-20","conditions":"Tracheal Intubation","enrollment":64},{"nctId":"NCT02880787","phase":"NA","title":"Comparison of Two Neuromuscular Transmission Monitors Based on Acceleromyography: TOF-Watch SX® and TOFScan®","status":"UNKNOWN","sponsor":"Central Hospital, Nancy, France","startDate":"2014-11","conditions":"Curarisation, Neuromuscular Monitoring","enrollment":142},{"nctId":"NCT02505841","phase":"NA","title":"Transversus Abdominis Plane Block for Laparoscopic Appendicectomy in Children","status":"UNKNOWN","sponsor":"University Hospital, Montpellier","startDate":"2015-05","conditions":"Laparoscopic Appendectomy","enrollment":240}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":42,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Curare (Atracurium)","genericName":"Curare (Atracurium)","companyName":"CHU de Reims","companyId":"chu-de-reims","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Atracurium is a non-depolarizing neuromuscular blocking agent that competitively antagonizes acetylcholine at the neuromuscular junction, causing paralysis. Used for Skeletal muscle relaxation during anesthesia and mechanical ventilation, Facilitation of endotracheal intubation.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}