{"id":"cultured-thymus-tissue","safety":{"commonSideEffects":[]},"_chembl":{"chemblId":"CHEMBL5315092","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Thymus tissue contains thymic epithelial cells and produces thymic hormones (such as thymosin and thymopoietin) that are essential for T-lymphocyte differentiation and maturation. By providing these factors, the cultured tissue aims to restore or enhance immune function, particularly in conditions characterized by thymic insufficiency or immune deficiency. This approach represents a form of cellular/tissue-based immunotherapy.","oneSentence":"Cultured thymus tissue provides thymic factors and hormones that support immune system development and T-cell maturation.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T00:31:31.233Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Immunodeficiency disorders"},{"name":"Thymic insufficiency"}]},"trialDetails":[{"nctId":"NCT05329935","phase":"","title":"Congenital Athymia Patient Registry","status":"RECRUITING","sponsor":"Sumitomo Pharma Switzerland GmbH","startDate":"2022-05-25","conditions":"Complete DiGeorge Anomaly, Complete DiGeorge Syndrome, Congenital Athymia","enrollment":75},{"nctId":"NCT02274662","phase":"PHASE4","title":"Expanded Access Protocol Thymus Transplantation","status":"COMPLETED","sponsor":"Sumitomo Pharma Switzerland GmbH","startDate":"2014-08","conditions":"Poor Thymic Function, Immunodeficiency, Athymia","enrollment":11},{"nctId":"NCT01220531","phase":"NA","title":"Thymus Transplantation Safety-Efficacy","status":"COMPLETED","sponsor":"Sumitomo Pharma Switzerland GmbH","startDate":"2010-12","conditions":"Complete DiGeorge Anomaly, DiGeorge Syndrome, DiGeorge Anomaly","enrollment":29},{"nctId":"NCT00849888","phase":"PHASE1","title":"Serum-Free Thymus Transplantation in DiGeorge Anomaly","status":"TERMINATED","sponsor":"Sumitomo Pharma Switzerland GmbH","startDate":"2008-04","conditions":"DiGeorge Anomaly","enrollment":2},{"nctId":"NCT00576836","phase":"PHASE2","title":"Thymus Transplantation Dose in DiGeorge #932","status":"COMPLETED","sponsor":"Sumitomo Pharma Switzerland GmbH","startDate":"2004-09-02","conditions":"DiGeorge Anomaly, DiGeorge Syndrome, Complete DiGeorge Anomaly","enrollment":7},{"nctId":"NCT00576407","phase":"PHASE2","title":"Thymus Transplantation in DiGeorge Syndrome #668","status":"COMPLETED","sponsor":"Sumitomo Pharma Switzerland GmbH","startDate":"1991-10","conditions":"DiGeorge Syndrome, Complete Typical DiGeorge Anomaly","enrollment":26},{"nctId":"NCT00579527","phase":"PHASE1, PHASE2","title":"Phase I/II Thymus Transplantation With Immunosuppression #950","status":"COMPLETED","sponsor":"Sumitomo Pharma Switzerland GmbH","startDate":"2005-12-19","conditions":"DiGeorge Anomaly, Complete DiGeorge Anomaly, Complete Atypical DiGeorge Anomaly","enrollment":14}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":16,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["RETHYMIC","allogeneic cultured thymus tissue-agdc","Thymus Tissue Transplant"],"phase":"marketed","status":"active","brandName":"Cultured Thymus Tissue","genericName":"Cultured Thymus Tissue","companyName":"Sumitomo Pharma Switzerland GmbH","companyId":"sumitomo-pharma-switzerland-gmbh","modality":"Biologic","firstApprovalDate":"","aiSummary":"Cultured thymus tissue provides thymic factors and hormones that support immune system development and T-cell maturation. Used for Immunodeficiency disorders, Thymic insufficiency.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":true,"score":3}}