{"id":"csl300","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Headache"},{"rate":"10-20%","effect":"Nausea"},{"rate":"5-10%","effect":"Infusion-related reactions"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"CSL300 works by inhibiting the complement system, specifically the C5 component, to prevent excessive inflammation and tissue damage. This mechanism is thought to be beneficial in treating conditions associated with complement system dysregulation.","oneSentence":"CSL300 is a recombinant human monoclonal antibody that targets the complement system.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T03:29:41.353Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Paroxysmal nocturnal hemoglobinuria (PNH)"}]},"trialDetails":[{"nctId":"NCT05485961","phase":"PHASE2, PHASE3","title":"Combined Dose-Finding and CV Outcomes Study With CSL300 (Clazakizumab) in Adult Subjects With ESKD Undergoing Dialysis","status":"RECRUITING","sponsor":"CSL Behring","startDate":"2022-10-21","conditions":"Atherosclerotic Cardiovascular Disease, End Stage Kidney Disease, Atherosclerotic Cardiovascular Disease in Patients With ESKD","enrollment":2310}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Clazakizumab"],"phase":"phase_2","status":"active","brandName":"CSL300","genericName":"CSL300","companyName":"CSL Behring","companyId":"csl-behring","modality":"Small molecule","firstApprovalDate":"","aiSummary":"CSL300 is a recombinant human monoclonal antibody that targets the complement system. Used for Paroxysmal nocturnal hemoglobinuria (PNH).","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}