{"id":"cryotherapy-with-liquid-nitrogen","safety":{"commonSideEffects":[{"rate":null,"effect":"Blistering and edema"},{"rate":null,"effect":"Pain and discomfort during/after procedure"},{"rate":null,"effect":"Hypopigmentation or hyperpigmentation"},{"rate":null,"effect":"Scarring"},{"rate":null,"effect":"Infection"}]},"_chembl":{"chemblId":"CHEMBL142438","moleculeType":"Small molecule","molecularWeight":"28.01"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Liquid nitrogen at extremely low temperatures (−196°C) is applied directly to target tissue, causing intracellular and extracellular ice formation that damages cell membranes and organelles. This leads to immediate cell death (necrosis) and subsequent immune-mediated destruction of treated lesions. The procedure is used primarily for localized skin lesions and superficial tumors.","oneSentence":"Cryotherapy with liquid nitrogen destroys tissue by rapid freezing, causing ice crystal formation and cellular death.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:07:56.310Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Skin cancer and precancerous lesions (actinic keratosis, basal cell carcinoma, squamous cell carcinoma)"},{"name":"Warts and benign skin growths"}]},"trialDetails":[{"nctId":"NCT07336368","phase":"PHASE3","title":"Topical Cryotherapy and Keloid/Hypertrophic Scars","status":"RECRUITING","sponsor":"Sonal Choudhary","startDate":"2026-03","conditions":"Keloid Scars, Hypertrophic Scars","enrollment":30},{"nctId":"NCT04996173","phase":"NA","title":"Cryospray Therapy Versus Standard of Care for Benign Airway Stenosis (CryoStasis)","status":"ACTIVE_NOT_RECRUITING","sponsor":"Vanderbilt University Medical Center","startDate":"2021-10-25","conditions":"Pulmonary Disease","enrollment":40},{"nctId":"NCT06085209","phase":"PHASE1","title":"Cryospray Therapy for Benign Airway Stenosis","status":"RECRUITING","sponsor":"Virginia Commonwealth University","startDate":"2023-10-12","conditions":"Stenosis Trachea","enrollment":12},{"nctId":"NCT07222657","phase":"PHASE2","title":"Liquid Nitrogen Spray Cryotherapy Prior to Neoadjuvant Systemic Therapy in Esophageal Adenocarcinoma","status":"NOT_YET_RECRUITING","sponsor":"Case Comprehensive Cancer Center","startDate":"2025-11","conditions":"Esophageal Adenocarcinoma, Esophageal Cancer","enrollment":40},{"nctId":"NCT07016360","phase":"PHASE4","title":"Comparison of Effectiveness of Topical Retinoids Versus Liquid Nitrogen in Treatment of Plantar Warts(Viral Infection)","status":"RECRUITING","sponsor":"Khyber Teaching Hospital","startDate":"2025-06-15","conditions":"Viral Warts","enrollment":98},{"nctId":"NCT06812819","phase":"","title":"Effect of Cryostimulation on Selected Motor Skills in Soccer Players","status":"APPROVED_FOR_MARKETING","sponsor":"Poznan University of Physical Education","startDate":"","conditions":"Particularly Partial-body Cryostimulation","enrollment":""},{"nctId":"NCT06718192","phase":"PHASE1, PHASE2","title":"A Randomized Controlled Trial to Evaluate the Effectiveness of Bleomycin and Cryotherapy in Treating Plantar Warts.","status":"RECRUITING","sponsor":"The Fourth Affiliated Hospital of Zhejiang University School of Medicine","startDate":"2024-12-25","conditions":"Verruca Plantaris","enrollment":70},{"nctId":"NCT05825547","phase":"NA","title":"Evaluation of Changes in the Immunological Microenvironment Surrounding Subcutaneous Breast Cancer Metastases After Liquid Nitrogen Cryotherapy","status":"COMPLETED","sponsor":"Centre Hospitalier Universitaire de Nīmes","startDate":"2022-02-16","conditions":"Breast Cancer","enrollment":5},{"nctId":"NCT06839638","phase":"NA","title":"Efficacy of 100% Trichloroacetic Acid Vs. 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an Alternative Home Cryotherapy Device for Wart Treatment","status":"COMPLETED","sponsor":"Mahidol University","startDate":"2020-11-12","conditions":"Cryotherapy Effect, Warts","enrollment":22},{"nctId":"NCT06193226","phase":"NA","title":"Is Cryotherapy Effective as a Therapeutic Option for Oral Lesion","status":"COMPLETED","sponsor":"October 6 University","startDate":"2023-02-01","conditions":"Cryotherapy, Oral Lesions","enrollment":15},{"nctId":"NCT06005389","phase":"","title":"Serum Galectin-3 as a Marker of Human Papillomavirus Infection","status":"COMPLETED","sponsor":"Assiut University","startDate":"2021-12-01","conditions":"Human Papillomavirus Infection","enrollment":100},{"nctId":"NCT05897112","phase":"PHASE1","title":"Comparative Efficacy of 10% Potassium Hydroxide Solution Versus Cryotherapy in Molluscum Contagiosum","status":"COMPLETED","sponsor":"Combined Military Hospital Abbottabad","startDate":"2022-11-01","conditions":"Molluscum Contagiosum","enrollment":60},{"nctId":"NCT05895071","phase":"PHASE1","title":"Comparison of Topical 5%Potassium Hydroxide vs Liquid Nitrogen in the Treatment of Plane Warts","status":"COMPLETED","sponsor":"Combined Military Hospital Abbottabad","startDate":"2022-11-01","conditions":"Plan Warts","enrollment":60},{"nctId":"NCT02572557","phase":"NA","title":"TruFreeze Cryotherapy Central Airway Disease","status":"COMPLETED","sponsor":"University Medical Center Groningen","startDate":"2016-12","conditions":"Airway Obstruction","enrollment":20},{"nctId":"NCT05165082","phase":"NA","title":"The Efficacy of Topical Timolol Combined With Cryotherapy in EGFR Inhibitors-induced Paronychia - a Double-blinded, Intrapatient Left-to-right Controlled Study","status":"COMPLETED","sponsor":"Taipei Medical University WanFang Hospital","startDate":"2021-12-21","conditions":"Paronychia, Epidermal Growth Factor Receptor Inhibitor","enrollment":8},{"nctId":"NCT05712811","phase":"NA","title":"Comparison of Cryotherapy and Peeling Agent in the Treatment of Common Warts","status":"COMPLETED","sponsor":"Combined Military Hospital Abbottabad","startDate":"2022-06-01","conditions":"Warts","enrollment":60},{"nctId":"NCT05616078","phase":"NA","title":"Laser Versus Cryotherapy for the Treatment of Recalcitrant Warts","status":"UNKNOWN","sponsor":"The 306 Hospital of People's Liberation Army","startDate":"2022-11","conditions":"Warts","enrollment":110},{"nctId":"NCT05588999","phase":"PHASE1","title":"Comparative Study Between Treatment With Cryotherapy Alone Versus Cryotherapy Plus Salicylic Acid Dressing for Planter Warts","status":"COMPLETED","sponsor":"Combined Military Hospital Abbottabad","startDate":"2022-03-01","conditions":"Plantar Wart","enrollment":70},{"nctId":"NCT05300009","phase":"NA","title":"Efficacy and Safety of Topical Methotrexate Gel 1% Coupled With Microneedling in Treatment of Warts","status":"UNKNOWN","sponsor":"Assiut University","startDate":"2022-06-15","conditions":"Warts","enrollment":68},{"nctId":"NCT01868139","phase":"NA","title":"Spray Cryotherapy for Esophageal Cancer (ICE-CANCER)","status":"TERMINATED","sponsor":"University of Maryland, Baltimore","startDate":"2013-06","conditions":"Esophageal Cancer","enrollment":1},{"nctId":"NCT03734003","phase":"NA","title":"Infrared Bioeffect System for the Treatment of Cutaneous Warts","status":"COMPLETED","sponsor":"First Hospital of China Medical University","startDate":"2018-08-08","conditions":"Cutaneous Warts, Human Papilloma Virus","enrollment":88},{"nctId":"NCT03982004","phase":"PHASE1","title":"Epicutaneous Cryoimmunotherapy Combined With Pembrolizumab for Cutaneous Metastatic Breast Cancer","status":"TERMINATED","sponsor":"Washington University School of Medicine","startDate":"2020-09-14","conditions":"Metastatic Breast Cancer","enrollment":1},{"nctId":"NCT01300975","phase":"PHASE2","title":"Intralesional Antimony for Bolivian Cutaneous Leishmaniasis","status":"COMPLETED","sponsor":"Fundacion Nacional de Dermatologia","startDate":"2011-01","conditions":"Leishmaniasis, Cutaneous Leishmaniasis","enrollment":90},{"nctId":"NCT04654091","phase":"NA","title":"Cryotherapy VS. Nitric-zinc Complex in the Treatment of Plantar Warts.","status":"UNKNOWN","sponsor":"Universidad Complutense de Madrid","startDate":"2021-01-01","conditions":"Plantar Wart","enrollment":18},{"nctId":"NCT04161274","phase":"NA","title":"Randomized Clinical Trial on Skin Tags Approachment.","status":"COMPLETED","sponsor":"Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina","startDate":"2019-01-01","conditions":"Skin Tags","enrollment":275},{"nctId":"NCT03183765","phase":"PHASE4","title":"Intralesional Measles, Mumps, Rubella (MMR) Vaccine Versus Cryotherapy in Treatment of Multiple Common and Planter Warts","status":"COMPLETED","sponsor":"Assiut University","startDate":"2017-08-01","conditions":"Common Wart, Plantar Wart","enrollment":48},{"nctId":"NCT04372784","phase":"NA","title":"Cryoablation for Benign Gastrointestinal Anastomotic Strictures","status":"UNKNOWN","sponsor":"University of Southern California","startDate":"2020-09","conditions":"Esophageal Stricture, Duodenal Stricture, Jejunal Stricture","enrollment":124},{"nctId":"NCT03285035","phase":"","title":"Quality of Life Assessment of Cryotherapy in Esophageal or Gastroesophageal Cancer","status":"UNKNOWN","sponsor":"Western Regional Medical Center","startDate":"2017-07-13","conditions":"Esophageal Cancer","enrollment":50},{"nctId":"NCT02847663","phase":"NA","title":"The Effect of Whole Body Cryotherapy on Recovery and Performance: a Randomized Controlled Trial","status":"COMPLETED","sponsor":"University of Applied Sciences and Arts of Southern Switzerland","startDate":"2016-04","conditions":"Cold","enrollment":30},{"nctId":"NCT00695578","phase":"PHASE4","title":"Clinical Trial to Evaluate Biafine Cream Versus Standard Care in Subjects With Actinic Keratosis Post Cryotherapy","status":"COMPLETED","sponsor":"Wake Forest University","startDate":"2006-10","conditions":"Actinic Keratosis","enrollment":20},{"nctId":"NCT02239679","phase":"PHASE2","title":"Controlled Study of the Occurrence of Actinic Keratosis on the Face After Cryotherapy + Aminolevulinic Acid (ALA) Photodynamic Therapy","status":"COMPLETED","sponsor":"DUSA Pharmaceuticals, Inc.","startDate":"2014-09","conditions":"Actinic Keratosis","enrollment":166},{"nctId":"NCT03473600","phase":"PHASE4","title":"Cryotherapy Versus Steroids In Alopecia Areata:Trichoscopic Evaluation","status":"UNKNOWN","sponsor":"Assiut University","startDate":"2018-11","conditions":"Alopecia Areata","enrollment":40},{"nctId":"NCT01609530","phase":"NA","title":"Pulsed 1064nm Nd:YAG in the Treatment of Verruca Vulgaris Versus Conventional Therapy With Liquid Nitrogen Cryotherapy","status":"TERMINATED","sponsor":"Trinity Health Michigan","startDate":"2012-01","conditions":"Verruca Vulgaris","enrollment":31},{"nctId":"NCT03425903","phase":"NA","title":"Evaluate the Clinical Efficacy of Whole Body Cryotherapy in the Cryosense Cabin for the Treatment of Fibromyalgia","status":"COMPLETED","sponsor":"Tecnología e Innovación Médico Estética S.L.","startDate":"2016-11-16","conditions":"Fibromyalgia","enrollment":60},{"nctId":"NCT03225729","phase":"NA","title":"Assessment of CRYOBEAUTY MAINS ET DECOLLETE Versus Liquid Nitrogen Cryotherapy, in the Treatment of Solar Lentigines","status":"COMPLETED","sponsor":"Cryobeauty","startDate":"2017-10-25","conditions":"Solar Lentigo","enrollment":30},{"nctId":"NCT02606396","phase":"NA","title":"Cryotherapy for Malignant Dysphagia in Patients With Advanced Esophageal Cancer","status":"UNKNOWN","sponsor":"Hunter Holmes Mcguire Veteran Affairs Medical Center","startDate":"2015-11","conditions":"Esophageal Adenocarcinoma","enrollment":15},{"nctId":"NCT01459393","phase":"PHASE3","title":"Comparison Between 5-aminolevulinic Acid Photodynamic Therapy Versus Cryotherapy for Actinic Keratosis Treatment","status":"COMPLETED","sponsor":"Barretos Cancer Hospital","startDate":"2010-11","conditions":"Actinic Keratosis","enrollment":137},{"nctId":"NCT01059110","phase":"PHASE4","title":"Comparison of Five Treatments in Patients With Plantar Warts","status":"TERMINATED","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2010-02","conditions":"Plantar Warts","enrollment":358},{"nctId":"NCT01845454","phase":"NA","title":"A Dose-Optimization Study for the Initial Treatment of Dysplastic Barrett's Esophagus With trūFreeze™ Spray Cryotherapy","status":"TERMINATED","sponsor":"CSA Medical, Inc.","startDate":"2013-04","conditions":"Barrett's Esophagus","enrollment":36},{"nctId":"NCT01633515","phase":"NA","title":"Intralesional Cryosurgery for Basal Cell Carcinoma - a Feasibility Study","status":"UNKNOWN","sponsor":"Carmel Medical Center","startDate":"2012-07","conditions":"Basal Cell Carcinoma (BCC)","enrollment":10},{"nctId":"NCT00650988","phase":"EARLY_PHASE1","title":"Cryotherapy for Barrett's Esophagus and Early Esophageal Cancers","status":"COMPLETED","sponsor":"Case Comprehensive Cancer Center","startDate":"2005-09","conditions":"Barretts Esophagus, Esophageal Cancer","enrollment":37},{"nctId":"NCT01084824","phase":"NA","title":"A Trial Examining the Treatment of Common Warts With Combination Liquid Nitrogen (LN2) and Cantharidin","status":"COMPLETED","sponsor":"North Idaho Dermatology","startDate":"2007-06","conditions":"Verruca Vulgaris","enrollment":70},{"nctId":"NCT00628784","phase":"PHASE4","title":"Endoesophageal Cryotherapy For Ablating Barrett's Esophagus and Early Stage Esophageal Cancer","status":"UNKNOWN","sponsor":"Walter Reed Army Medical Center","startDate":"2007-03","conditions":"Barrett's Esophagus","enrollment":100}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":547,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Cry-ac ®"],"phase":"phase_3","status":"active","brandName":"Cryotherapy with liquid nitrogen","genericName":"Cryotherapy with liquid nitrogen","companyName":"Barretos Cancer Hospital","companyId":"barretos-cancer-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Liquid nitrogen is used as an intervention in cryotherapy for conditions such as Airway Obstruction, Molluscum Contagiosum, Esophageal Cancer, Actinic Keratosis, and Plantar Wart, as seen in clinical trials registered on ClinicalTrials.gov. Cryotherapy with liquid nitrogen is a small molecule modality, as classified by ChEMBL, which lists liquid nitrogen as a synonym for the compound E-941.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}