{"id":"cryopreserved-platelets","safety":{"commonSideEffects":[{"rate":null,"effect":"Transfusion reaction"},{"rate":null,"effect":"Alloimmunization"},{"rate":null,"effect":"Platelet refractoriness"},{"rate":null,"effect":"Infection risk (if contamination occurs)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Cryopreservation uses cryoprotectants and controlled freezing to maintain platelet viability during long-term storage at ultra-low temperatures, extending shelf life beyond the standard 5-day room-temperature storage. Upon thawing and transfusion, these platelets restore platelet count and function to support hemostasis in critically ill or bleeding patients. This approach addresses the logistical challenges of platelet inventory management and availability in emergency and intensive care settings.","oneSentence":"Cryopreserved platelets are platelets that have been frozen and stored for extended periods, then thawed for transfusion to restore hemostatic function in patients with thrombocytopenia or platelet dysfunction.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:07:57.117Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Thrombocytopenia in critically ill patients requiring platelet transfusion"},{"name":"Perioperative bleeding management in patients with platelet dysfunction or deficiency"}]},"trialDetails":[{"nctId":"NCT06859424","phase":"PHASE2","title":"A Platform Protocol to Investigate Post-Transplant Cyclophosphamide-Based Graft-Versus-Host Disease Prophylaxis in Patients With Hematologic Malignancies Undergoing Mismatched Unrelated Donor Peripheral Blood Stem Cell Transplantation","status":"RECRUITING","sponsor":"Center for International Blood and Marrow Transplant Research","startDate":"2025-07-25","conditions":"AML (Acute Myelogenous Leukemia), Acute Lymphoid Leukemia (ALL), Acute Leukemia (Category)","enrollment":358},{"nctId":"NCT06147531","phase":"PHASE2","title":"Delayed Cold-Stored Platelets -PLTS-1","status":"RECRUITING","sponsor":"University Health Network, Toronto","startDate":"2024-06-05","conditions":"Platelets, Bleeding, Cardiopulmonary Bypass","enrollment":150},{"nctId":"NCT07235436","phase":"","title":"Platelet Cryopreservation","status":"COMPLETED","sponsor":"Azienda USL Reggio Emilia - IRCCS","startDate":"2020-12-31","conditions":"Platelet Cryopreservation","enrollment":10},{"nctId":"NCT04709705","phase":"PHASE2, PHASE3","title":"DMSO Cryopreserved Platelets in Cardiopulmonary Bypass Surgery (CRYPTICS)","status":"COMPLETED","sponsor":"Cellphire Therapeutics, Inc.","startDate":"2021-10-27","conditions":"Cardiac Surgery","enrollment":161},{"nctId":"NCT03991481","phase":"PHASE3","title":"The Cryopreserved vs. Liquid Platelets Trial","status":"ACTIVE_NOT_RECRUITING","sponsor":"Australian and New Zealand Intensive Care Research Centre","startDate":"2021-08-17","conditions":"Surgical Blood Loss, Hemorrhage","enrollment":388},{"nctId":"NCT01892670","phase":"NA","title":"Storage Temperature and Quality of Leucoreduced Whole Blood","status":"COMPLETED","sponsor":"Haukeland University Hospital","startDate":"2013-03","conditions":"Trauma, Austere Environment, Blood Bank","enrollment":87},{"nctId":"NCT06261658","phase":"NA","title":"Improving the Quality of Cryopreserved Ovarian Tissue Reimplantation Using Platelet-enriched Autologous Plasma","status":"RECRUITING","sponsor":"IRCCS Azienda Ospedaliero-Universitaria di Bologna","startDate":"2024-03-01","conditions":"Cryopreservation, Ovary Injury, Infertility, Female","enrollment":45},{"nctId":"NCT06258759","phase":"NA","title":"The Effects of Autologous Platelet-rich Plasma Supplement During Sperm Cryopreservation on Post-cryopreserved Sperm Quality","status":"UNKNOWN","sponsor":"Department of Medical Services Ministry of Public Health of Thailand","startDate":"2024-01-01","conditions":"Autologous Platelet-rich Plasma Supplement, Sperm Cryopreservation, Post-cryopreserved Sperm Quality","enrollment":20},{"nctId":"NCT05761457","phase":"NA","title":"Efficacy and Safety of Autologous Cryopreserved Platelets in Patients With PTR","status":"UNKNOWN","sponsor":"The First Affiliated Hospital of Soochow University","startDate":"2023-03-01","conditions":"Platelet Transfusion Refractoriness","enrollment":25},{"nctId":"NCT05502809","phase":"PHASE3","title":"Frozen Platelets in the Treatmentof Traumatic or Vascular Bleeding","status":"UNKNOWN","sponsor":"Alrijne Ziekenhuis Leiderdorp","startDate":"2023-06-01","conditions":"Trauma, Bleeding","enrollment":158},{"nctId":"NCT05067608","phase":"PHASE1, PHASE2","title":"Study on the Safety and Efficacy of Cryopreserved Platelets in Hypoproliferative Thrombocytopenic Patients","status":"COMPLETED","sponsor":"Singapore General Hospital","startDate":"2019-10-25","conditions":"Hypoproliferative Thrombocytopenia","enrollment":17},{"nctId":"NCT04754841","phase":"NA","title":"STUDY OF SURVIVAL AND FUNCTIONALITY IN CRYOPRESERVED PLATELETS","status":"UNKNOWN","sponsor":"HOSPITAL BRITANICO DE BUENOS AIRES","startDate":"2021-02-03","conditions":"Platelet Cryopreservation, Platelet Survival","enrollment":281},{"nctId":"NCT02078284","phase":"PHASE1","title":"Phase 1 Safety Study of Dimethyl Sulfoxide Cryopreserved Platelets","status":"COMPLETED","sponsor":"U.S. Army Medical Research and Development Command","startDate":"2014-11-05","conditions":"Thrombocytopenia","enrollment":28},{"nctId":"NCT00038012","phase":"NA","title":"rhTPO Mobilized Auto Cryo Platelets For GYN Patients Receiving Carboplatin","status":"COMPLETED","sponsor":"M.D. Anderson Cancer Center","startDate":"1999-07-23","conditions":"Neoplasms, Gynecologic","enrollment":33},{"nctId":"NCT02754414","phase":"PHASE1","title":"Cold Apheresis Platelets in PAS","status":"UNKNOWN","sponsor":"Bloodworks","startDate":"2016-04","conditions":"Platelet Transfusion","enrollment":80},{"nctId":"NCT02032134","phase":"PHASE4","title":"Protocol for the Infusion of Buffy Coat-derived Cryopreserved Platelets in Patients With Severe Thrombocytopenia","status":"TERMINATED","sponsor":"Napolitano Mariasanta","startDate":"2015-07","conditions":"Thrombocytopenia, Primary Thrombocytopenia,Unspecified, Thrombocytopenia Chemotherapy Induced","enrollment":5},{"nctId":"NCT02389010","phase":"PHASE3","title":"Clinical Efficacy of Platelet Gel From Cord Blood for the Treatment of Diabetic Foot Ulcers","status":"COMPLETED","sponsor":"Centro Nazionale Sangue","startDate":"2015-01","conditions":"Diabetic Foot Ulcers","enrollment":50},{"nctId":"NCT03113747","phase":"PHASE1, PHASE2","title":"Allogeneic ADSCs and Platelet-Poor Plasma Fibrin Hydrogel to Treat the Patients With Burn Wounds (ADSCs-BWs)","status":"UNKNOWN","sponsor":"A.A. Partners, LLC","startDate":"2015-03-25","conditions":"Second- or Third-degree Burns","enrollment":20},{"nctId":"NCT00074763","phase":"PHASE3","title":"Comparing Fresh Random Platelets and Autologous Cryopreserved Thrombosol Treated Autologous Platelets","status":"TERMINATED","sponsor":"M.D. Anderson Cancer Center","startDate":"2003-07","conditions":"Leukemia, Lymphoma","enrollment":4}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":122,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Cryopreserved platelets","genericName":"Cryopreserved platelets","companyName":"Australian and New Zealand Intensive Care Research Centre","companyId":"australian-and-new-zealand-intensive-care-research-centre","modality":"Biologic","firstApprovalDate":"","aiSummary":"Cryopreserved platelets are platelets that have been frozen and stored for extended periods, then thawed for transfusion to restore hemostatic function in patients with thrombocytopenia or platelet dysfunction. Used for Thrombocytopenia in critically ill patients requiring platelet transfusion, Perioperative bleeding management in patients with platelet dysfunction or deficiency.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}