{"id":"crushed-ticagrelor-morphine-metoclopramide","safety":{"commonSideEffects":[{"rate":null,"effect":"Bleeding"},{"rate":null,"effect":"Bradycardia"},{"rate":null,"effect":"Respiratory depression"},{"rate":null,"effect":"Constipation"},{"rate":null,"effect":"Tardive dyskinesia (metoclopramide)"}]},"_chembl":{"chemblId":"CHEMBL398435","moleculeType":"Small molecule","molecularWeight":"522.58"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Ticagrelor is a P2Y12 receptor antagonist that prevents platelet activation and aggregation, reducing thrombotic events in acute coronary syndromes. Morphine is an opioid agonist providing analgesia and anxiolysis. Metoclopramide is a dopamine antagonist that increases gastric contractions and blocks chemoreceptor-mediated nausea, commonly used to counteract opioid-induced gastrointestinal effects and improve drug absorption.","oneSentence":"This combination uses ticagrelor to inhibit platelet aggregation, morphine for pain relief and anxiolysis, and metoclopramide to enhance gastric motility and reduce nausea.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:31:25.420Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute coronary syndrome with associated pain and nausea"}]},"trialDetails":[{"nctId":"NCT02939235","phase":"PHASE4","title":"Influence of Metoclopramide on Ticagrelor Pharmacokinetics and Pharmacodynamics in Patients With Unstable Angina Pectoris on Concomitant Treatment With Morphine","status":"COMPLETED","sponsor":"Collegium Medicum w Bydgoszczy","startDate":"2016-07","conditions":"Unstable Angina Pectoris","enrollment":32}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Brilique"],"phase":"marketed","status":"active","brandName":"Crushed ticagrelor, morphine,metoclopramide","genericName":"Crushed ticagrelor, morphine,metoclopramide","companyName":"Collegium Medicum w Bydgoszczy","companyId":"collegium-medicum-w-bydgoszczy","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This combination uses ticagrelor to inhibit platelet aggregation, morphine for pain relief and anxiolysis, and metoclopramide to enhance gastric motility and reduce nausea. Used for Acute coronary syndrome with associated pain and nausea.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}