{"id":"crofab","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypersensitivity reactions"},{"rate":null,"effect":"Serum sickness"},{"rate":null,"effect":"Coagulopathy recurrence"}]},"_chembl":null,"_dailymed":{"setId":"77abd784-3387-420d-abdc-4fe97215d233","title":"CROFAB (OVINE CROTALIDAE VENOMS IMMUNE FAB) INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION [BTG INTERNATIONAL INC.]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"CroFab contains immunoglobulin fragments (Fab) derived from sheep immunized with crotalid snake venoms. These Fab fragments bind to and neutralize multiple venom components including phospholipase A2, serine proteases, and metalloproteinases, preventing their pathological effects on coagulation, hemolysis, and tissue damage. The drug is administered intravenously to treat envenomation by North American pit vipers.","oneSentence":"CroFab is a polyclonal antivenom that binds and neutralizes venom toxins from North American crotalid snakes (rattlesnakes, cottonmouths, and copperheads).","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T03:29:35.306Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Envenomation by North American crotalid snakes (rattlesnakes, cottonmouths, copperheads)"}]},"trialDetails":[{"nctId":"NCT04210141","phase":"PHASE2","title":"Optimal Dose of Antivenom for Daboia Siamensis Envenomings","status":"SUSPENDED","sponsor":"Myanmar Oxford Clinical Research Unit","startDate":"2025-04","conditions":"Daboia Siamensis Envenoming","enrollment":200},{"nctId":"NCT00303303","phase":"PHASE4","title":"The Efficacy of Crotaline Fab Antivenom for Copperhead Snake Envenomations","status":"TERMINATED","sponsor":"Wake Forest University Health Sciences","startDate":"2005-04","conditions":"Snake Envenomation","enrollment":13},{"nctId":"NCT00927381","phase":"","title":"Retrospective Evaluation of CroFab - Efficacy in Severe Envenomation","status":"COMPLETED","sponsor":"BTG International Inc.","startDate":"2005-01","conditions":"Snake Envenomation","enrollment":247},{"nctId":"NCT01864200","phase":"PHASE4","title":"Randomized, Double-Blind, Placebo-Controlled Study: CroFab® vs Placebo for Copperhead Snake Envenomation","status":"COMPLETED","sponsor":"BTG International Inc.","startDate":"2013-07","conditions":"Snake Bites","enrollment":74},{"nctId":"NCT00868309","phase":"PHASE2","title":"A Comparison of Crotalinae Equine Immune F(ab)2 Antivenom (Anavip) and Crotalidae Polyvalent Immune Fab,","status":"COMPLETED","sponsor":"Instituto Bioclon S.A. de C.V.","startDate":"2005-01","conditions":"Snake Bite, Blood Coagulation Disorders","enrollment":12},{"nctId":"NCT00636116","phase":"PHASE3","title":"Phase 3 Multicenter Comparative Study to Confirm Safety and Effectiveness of the F(ab)2 Antivenom Anavip.","status":"COMPLETED","sponsor":"Instituto Bioclon S.A. de C.V.","startDate":"2008-05","conditions":"Snake Bite","enrollment":121}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"CroFab","genericName":"CroFab","companyName":"Instituto Bioclon S.A. de C.V.","companyId":"instituto-bioclon-s-a-de-c-v","modality":"Biologic","firstApprovalDate":"","aiSummary":"CroFab is a polyclonal antivenom that binds and neutralizes venom toxins from North American crotalid snakes (rattlesnakes, cottonmouths, and copperheads). Used for Envenomation by North American crotalid snakes (rattlesnakes, cottonmouths, copperheads).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}