{"id":"croconazole","rwe":[{"pmid":"37583758","year":"2023","title":"Advances of liposomal mediated nanocarriers for the treatment of dermatophyte infections.","finding":"","journal":"Heliyon","studyType":"Clinical Study"},{"pmid":"34553102","year":"2021","title":"Nanoliposome-loaded antifungal drugs for dermal administration: A review.","finding":"","journal":"Current medical mycology","studyType":"Clinical Study"},{"pmid":"24116896","year":"2014","title":"Comparative topical delivery of antifungal drug croconazole using liposome and micro-emulsion-based gel formulations.","finding":"","journal":"Drug delivery","studyType":"Clinical Study"},{"pmid":"23006761","year":"2012","title":"Screening of antifungal azole drugs and agrochemicals with an adapted alamarBlue-based assay demonstrates antibacterial activity of croconazole against Mycobacterium ulcerans.","finding":"","journal":"Antimicrobial agents and chemotherapy","studyType":"Clinical Study"},{"pmid":"21920030","year":"2011","title":"Synthesis and antifungal activity of 1-[(2-benzyloxy)phenyl]-2-(azol-1-yl)ethanone derivatives: exploring the scaffold flexibility.","finding":"","journal":"Chemical biology & drug design","studyType":"Clinical Study"}],"tags":[{"label":"croconazole","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"},{"label":"Candidiasis of skin","category":"indication"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"viniconazole","offLabel":[],"synonyms":["croconazole hydrochloride","croconazole HCl","croconazole","viniconazole"],"timeline":[],"approvals":[],"brandName":"Viniconazole","ecosystem":[{"indication":"Candidiasis of skin","otherDrugs":[{"name":"amphotericin B","slug":"amphotericin-b","company":"Apothecon"},{"name":"ciclopirox","slug":"ciclopirox","company":"Medimetriks Pharms"},{"name":"clotrimazole","slug":"clotrimazole","company":""},{"name":"econazole","slug":"econazole","company":""}],"globalPrevalence":null}],"mechanism":{"modality":"Small Molecule","drugClass":"croconazole","explanation":"Imagine your body is a garden, and the fungi are weeds. Viniconazole is like a weed killer that stops the weeds from growing and spreading. It does this by interfering with the way the fungi make energy, which ultimately kills the fungus.","oneSentence":"Viniconazole works by inhibiting the growth of fungi.","technicalDetail":"Viniconazole exerts its antifungal effects by inhibiting the synthesis of ergosterol, an essential component of fungal cell membranes, through the inhibition of the enzyme lanosterol 14α-demethylase."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/740","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=CROCONAZOLE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T10:19:26.670206","biosimilars":[],"competitors":[],"genericName":"croconazole","indications":{"approved":[{"name":"Candidiasis of skin","source":"DrugCentral","snomedId":49883006,"regulator":"FDA"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"007031","UNII":"446254H55G","CHEBI":"CHEBI:3920","INN_ID":"5932","RXNORM":"21753","UMLSCUI":"C0056504","ChEMBL_ID":"CHEMBL27289","KEGG_DRUG":"D07752","PUBCHEM_CID":"2880","SECONDARY_CAS_RN":"77174-66-4","MESH_SUPPLEMENTAL_RECORD_UI":"C038008"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":22,"therapeuticAreas":["Dermatology"],"biosimilarFilings":[],"recentPublications":[{"date":"2023 Aug","pmid":"37583758","title":"Advances of liposomal mediated nanocarriers for the treatment of dermatophyte infections.","journal":"Heliyon"},{"date":"2021 Mar","pmid":"34553102","title":"Nanoliposome-loaded antifungal drugs for dermal administration: A review.","journal":"Current medical mycology"},{"date":"2014 Feb","pmid":"24116896","title":"Comparative topical delivery of antifungal drug croconazole using liposome and micro-emulsion-based gel formulations.","journal":"Drug delivery"},{"date":"2012 Dec","pmid":"23006761","title":"Screening of antifungal azole drugs and agrochemicals with an adapted alamarBlue-based assay demonstrates antibacterial activity of croconazole against Mycobacterium ulcerans.","journal":"Antimicrobial agents and chemotherapy"},{"date":"2011 Dec","pmid":"21920030","title":"Synthesis and antifungal activity of 1-[(2-benzyloxy)phenyl]-2-(azol-1-yl)ethanone derivatives: exploring the scaffold flexibility.","journal":"Chemical biology & drug design"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Viniconazole, also known as Croconazole, is a small molecule drug in the croconazole class. It is used to treat Candidiasis of the skin, a fungal infection. The commercial status of Viniconazole is not specified, but it is likely patented as its original developer and current owner are not provided. Key safety considerations are not available. Viniconazole works by inhibiting the growth of fungi.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":false,"score":2}}