{"id":"creosote","rwe":[{"pmid":"41726845","year":"2026","title":"Spatial Distribution of Polycyclic Aromatic Hydrocarbons in Soil and Potential Human Health Risks within a Confirmed Cancer Cluster in the Greater Fifth Ward, Houston, Texas.","finding":"","journal":"Exposure and health","studyType":"Clinical Study"},{"pmid":"41683386","year":"2026","title":"Utilization of Organic Solvents for the Recycling of Waste Wooden Railroad Ties.","finding":"","journal":"Molecules (Basel, Switzerland)","studyType":"Clinical Study"},{"pmid":"41523875","year":"2026","title":"Application of the solvent effect on bioluminescent reporter bacteria as a real-time membrane toxicity assay.","finding":"","journal":"Access microbiology","studyType":"Clinical Study"},{"pmid":"41406527","year":"2026","title":"Gas-facilitated NAPL transport during bench-scale thermal conduction heating experiments.","finding":"","journal":"Journal of hazardous materials","studyType":"Clinical Study"},{"pmid":"41330558","year":"2025","title":"DNAPL Detection and Delineation with the Radon-Deficit Technique: Analysis of Applicability and Limitations with a Real Case-Study.","finding":"","journal":"Environmental science & technology","studyType":"Clinical Study"}],"tags":[{"label":"Small Molecule","category":"modality"},{"label":"R05CA08","category":"atc"},{"label":"Active","category":"status"},{"label":"Lin Jiacheng","category":"company"}],"phase":"phase_1","safety":{},"trials":[],"aliases":["oily liquid obtained by distillation of wood tar"],"company":"Lin Jiacheng","patents":[],"pricing":[],"allNames":"beechwood creosote","offLabel":[],"synonyms":["creosote","creosote carbonate","beechwood creosote"],"timeline":[],"approvals":[],"brandName":"Beechwood Creosote","ecosystem":[],"mechanism":{"modality":"Small Molecule","explanation":"Imagine your body's cells are like a city with many different buildings. Creosote is like a key that unlocks a specific building, allowing it to function properly. This can help to restore balance and health to the city, but more research is needed to understand exactly how it works.","oneSentence":"Beechwood Creosote is a small molecule compound that works by interacting with cellular targets to produce a therapeutic effect.","technicalDetail":"The exact mechanism of action of Beechwood Creosote is unknown, but it is believed to interact with cellular targets through a small molecule modality."},"_wikipedia":{"url":"https://en.wikipedia.org/wiki/Creosote","title":"Creosote","extract":"Creosote is a category of carbonaceous chemicals formed by the distillation of various tars and pyrolysis of plant-derived material, such as wood, or fossil fuel. They are typically used as preservatives or antiseptics."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/4859","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=creosote","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=creosote","fields":["publications"],"source":"PubMed/NCBI"},{"id":4,"url":"https://en.wikipedia.org/wiki/Creosote","fields":["history","overview"],"source":"Wikipedia"}],"_enrichedAt":"2026-03-30T10:22:41.132642","_validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T09:48:23.997846+00:00","fieldsConflicting":0,"overallConfidence":0.95},"biosimilars":[],"competitors":[{"drugName":"tyloxapol","drugSlug":"tyloxapol","fdaApproval":"1990-08-02","relationship":"same-class"},{"drugName":"potassium iodide","drugSlug":"potassium-iodide","fdaApproval":"1979-11-09","genericCount":3,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"guaifenesin","drugSlug":"guaifenesin","fdaApproval":"2002-07-12","genericCount":9,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"cineole","drugSlug":"cineole","fdaApproval":"","relationship":"same-class"}],"genericName":"creosote","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"tyloxapol","brandName":"tyloxapol","genericName":"tyloxapol","approvalYear":"1990","relationship":"same-class"},{"drugId":"potassium-iodide","brandName":"potassium iodide","genericName":"potassium iodide","approvalYear":"1979","relationship":"same-class"},{"drugId":"guaifenesin","brandName":"guaifenesin","genericName":"guaifenesin","approvalYear":"2002","relationship":"same-class"},{"drugId":"cineole","brandName":"cineole","genericName":"cineole","approvalYear":"","relationship":"same-class"}],"trialDetails":[{"nctId":"NCT02196740","phase":"NA","title":"Research of the Application of Triple Antibiotic Paste in Primary Teeth With Pericpical Periodontitis","status":"UNKNOWN","sponsor":"Lin Jiacheng","startDate":"2013-06","conditions":["Periapical Diseases"],"enrollment":100,"completionDate":"2015-06"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NUI":"N0000006742","NDDF":"000733","UNII":"QCL3NBR3M4","RXNORM":"2915","UMLSCUI":"C0010303","ChEMBL_ID":"CHEMBL2108245","DRUGBANK_ID":"DB13271","PUBCHEM_CID":"460","SNOMEDCT_US":"111093005","MESH_DESCRIPTOR_UI":"D003407"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[{"period":"present","companyName":"Lin Jiacheng","relationship":"Current Owner"}],"publicationCount":736,"therapeuticAreas":["Other"],"atcClassification":{"source":"DrugCentral","atcCode":"R05CA08","allCodes":["R05CA08"]},"biosimilarFilings":[],"recentPublications":[{"date":"2026","pmid":"41726845","title":"Spatial Distribution of Polycyclic Aromatic Hydrocarbons in Soil and Potential Human Health Risks within a Confirmed Cancer Cluster in the Greater Fifth Ward, Houston, Texas.","journal":"Exposure and health"},{"date":"2026 Jan 24","pmid":"41683386","title":"Utilization of Organic Solvents for the Recycling of Waste Wooden Railroad Ties.","journal":"Molecules (Basel, Switzerland)"},{"date":"2026","pmid":"41523875","title":"Application of the solvent effect on bioluminescent reporter bacteria as a real-time membrane toxicity assay.","journal":"Access microbiology"},{"date":"2026 Jan 1","pmid":"41406527","title":"Gas-facilitated NAPL transport during bench-scale thermal conduction heating experiments.","journal":"Journal of hazardous materials"},{"date":"2025 Dec 16","pmid":"41330558","title":"DNAPL Detection and Delineation with the Radon-Deficit Technique: Analysis of Applicability and Limitations with a Real Case-Study.","journal":"Environmental science & technology"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"Lin Jiacheng","companyId":"lin-jiacheng","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Beechwood Creosote has been studied in clinical trials for the treatment of periapical diseases, specifically in combination with a triple antibiotic paste. According to its chemical properties, Beechwood Creosote is a category of carbonaceous chemicals used as preservatives or antiseptics.","enrichmentLevel":5,"visitCount":0,"trialStats":{"total":0,"withResults":0},"validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T09:48:23.997846+00:00","fieldsConflicting":0,"overallConfidence":0.95},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":true,"score":2}}