{"id":"creon-35-000-ph-u-r","safety":{"commonSideEffects":[{"rate":null,"effect":"Abdominal pain"},{"rate":null,"effect":"Diarrhea"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Constipation"},{"rate":null,"effect":"Fibrosing colonopathy (rare, high-dose)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Creon contains pancreatic enzymes derived from porcine pancreas that are enteric-coated to survive stomach acid and release in the small intestine. These enzymes compensate for insufficient endogenous pancreatic enzyme production, enabling proper breakdown and absorption of dietary macronutrients in patients with conditions causing pancreatic insufficiency.","oneSentence":"Creon is a pancreatic enzyme replacement therapy that supplies lipase, amylase, and protease to aid digestion of fats, carbohydrates, and proteins in patients with pancreatic insufficiency.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:44:05.248Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Pancreatic insufficiency due to cystic fibrosis"},{"name":"Pancreatic insufficiency due to chronic pancreatitis"},{"name":"Pancreatic insufficiency following pancreatic surgery"}]},"trialDetails":[{"nctId":"NCT06099119","phase":"PHASE4","title":"Efficacy of PERT for PEI in Unresectable Pancreatic Cancer.","status":"RECRUITING","sponsor":"Hospital Clinico Universitario de Santiago","startDate":"2024-02-20","conditions":"Unresectable Pancreatic Cancer","enrollment":100}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"creon 35.000 Ph.U (R)","genericName":"creon 35.000 Ph.U (R)","companyName":"Hospital Clinico Universitario de Santiago","companyId":"hospital-clinico-universitario-de-santiago","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Creon is a pancreatic enzyme replacement therapy that supplies lipase, amylase, and protease to aid digestion of fats, carbohydrates, and proteins in patients with pancreatic insufficiency. Used for Pancreatic insufficiency due to cystic fibrosis, Pancreatic insufficiency due to chronic pancreatitis, Pancreatic insufficiency following pancreatic surgery.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}