{"id":"creatinolfosfate","rwe":[{"pmid":"6542374","year":"1984","title":"Action of creatinol-O-phosphate on the contractility changes evoked by hypoxia and ischemia in rat isolated heart.","finding":"","journal":"Arzneimittel-Forschung","studyType":"Clinical Study"}],"tags":[{"label":"creatinolfosfate","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"C01EB05","category":"atc"},{"label":"Active","category":"status"}],"phase":"phase_3","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"aplodan","offLabel":[],"synonyms":["creatinolfosfate","creatinol phosphate","aplodan"],"timeline":[],"approvals":[],"brandName":"Aplodan","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"creatinolfosfate","explanation":"Think of creatine like a fuel source for your muscles. When you exercise, your muscles use up energy stores, but with Aplodan, you have more fuel available to help you power through your workout. This can be especially helpful for people who engage in high-intensity activities or have muscle weakness.","oneSentence":"Aplodan works by increasing the levels of creatine in the body, which can help to improve muscle strength and endurance.","technicalDetail":"Aplodan, as a creatinolfosfate, is thought to work by increasing the levels of phosphocreatine in the muscle, which can help to rapidly replenish ATP stores during high-intensity exercise."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/739","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=CREATINOLFOSFATE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T10:18:55.561691","_validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T08:41:09.484559+00:00","fieldsConflicting":0,"overallConfidence":0.95},"biosimilars":[],"competitors":[{"drugName":"camphor","drugSlug":"camphor","fdaApproval":"","relationship":"same-class"},{"drugName":"indomethacin","drugSlug":"indomethacin","fdaApproval":"1965-06-10","patentExpiry":"Apr 23, 2030","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"ubidecarenone","drugSlug":"ubidecarenone","fdaApproval":"","relationship":"same-class"},{"drugName":"adenosine","drugSlug":"adenosine","fdaApproval":"1989-10-30","genericCount":15,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"ibuprofen","drugSlug":"ibuprofen","fdaApproval":"1974-09-19","patentExpiry":"Sep 30, 2029","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"ivabradine","drugSlug":"ivabradine","fdaApproval":"2015-04-15","patentExpiry":"Feb 22, 2026","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"ranolazine","drugSlug":"ranolazine","fdaApproval":"2006-01-27","patentExpiry":"Jan 24, 2038","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"regadenoson","drugSlug":"regadenoson","fdaApproval":"2008-04-10","patentExpiry":"Feb 2, 2027","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"mavacamten","drugSlug":"mavacamten","fdaApproval":"2022-04-28","patentExpiry":"Jun 19, 2034","patentStatus":"Patent protected","relationship":"same-class"}],"genericName":"creatinolfosfate","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"camphor","brandName":"camphor","genericName":"camphor","approvalYear":"","relationship":"same-class"},{"drugId":"indomethacin","brandName":"indomethacin","genericName":"indomethacin","approvalYear":"1965","relationship":"same-class"},{"drugId":"ubidecarenone","brandName":"ubidecarenone","genericName":"ubidecarenone","approvalYear":"","relationship":"same-class"},{"drugId":"adenosine","brandName":"adenosine","genericName":"adenosine","approvalYear":"1989","relationship":"same-class"},{"drugId":"ibuprofen","brandName":"ibuprofen","genericName":"ibuprofen","approvalYear":"1974","relationship":"same-class"},{"drugId":"ivabradine","brandName":"ivabradine","genericName":"ivabradine","approvalYear":"2015","relationship":"same-class"},{"drugId":"ranolazine","brandName":"ranolazine","genericName":"ranolazine","approvalYear":"2006","relationship":"same-class"},{"drugId":"regadenoson","brandName":"regadenoson","genericName":"regadenoson","approvalYear":"2008","relationship":"same-class"},{"drugId":"mavacamten","brandName":"mavacamten","genericName":"mavacamten","approvalYear":"2022","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"5O564RN1QD","CHEBI":"CHEBI:134856","INN_ID":"2460","UMLSCUI":"C0056471","ChEMBL_ID":"CHEMBL2104114","KEGG_DRUG":"D07162","DRUGBANK_ID":"DB13071","PUBCHEM_CID":"23342","MESH_SUPPLEMENTAL_RECORD_UI":"C100173"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":1,"therapeuticAreas":["Other"],"atcClassification":{"source":"DrugCentral","atcCode":"C01EB05","allCodes":["C01EB05"]},"biosimilarFilings":[],"recentPublications":[{"date":"1984","pmid":"6542374","title":"Action of creatinol-O-phosphate on the contractility changes evoked by hypoxia and ischemia in rat isolated heart.","journal":"Arzneimittel-Forschung"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Aplodan, also known as creatinolfosfate, is a small molecule drug in the creatinolfosfate class. Unfortunately, there is limited information available on this compound, including its target, approved indications, and commercial status. As a result, it is difficult to provide a comprehensive summary of its use and safety profile. Further research is needed to determine the potential benefits and risks of Aplodan. Its development and current status are unclear.","enrichmentLevel":5,"visitCount":0,"trialStats":{"total":0,"withResults":0},"validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T08:41:09.484559+00:00","fieldsConflicting":0,"overallConfidence":0.95},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}