{"id":"cq-coadministered-with-pq","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal disturbance (nausea, vomiting, abdominal pain)"},{"rate":null,"effect":"Hemolysis (in G6PD-deficient patients from primaquine)"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Pruritus"},{"rate":null,"effect":"Dizziness"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Chloroquine inhibits heme polymerization in the parasite's digestive vacuole, killing asexual blood stages of malaria parasites. Primaquine acts on hypnozoites in the liver, preventing relapse by eliminating the dormant tissue stages, particularly in P. vivax and P. ovale infections. The combination provides comprehensive parasite clearance across all life cycle stages.","oneSentence":"CQ (chloroquine) and PQ (primaquine) work together as antimalarial agents that disrupt parasite metabolism and eliminate both blood and tissue stages of Plasmodium infection.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:07:52.939Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Malaria (mixed species or P. vivax/P. ovale with relapse prevention)"},{"name":"Uncomplicated malaria treatment and radical cure"}]},"trialDetails":[{"nctId":"NCT03208907","phase":"PHASE3","title":"DHA-PQP vs Chloroquine and Primaquine for Radical Cure of Vivax Malaria in Brazil","status":"COMPLETED","sponsor":"Fundação de Medicina Tropical Dr. Heitor Vieira Dourado","startDate":"2018-07-05","conditions":"Malaria, Vivax, Therapeutics","enrollment":419}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":4,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Standard treatment with potential synergy"],"phase":"phase_3","status":"active","brandName":"CQ coadministered with PQ","genericName":"CQ coadministered with PQ","companyName":"Fundação de Medicina Tropical Dr. Heitor Vieira Dourado","companyId":"funda-o-de-medicina-tropical-dr-heitor-vieira-dourado","modality":"Small molecule","firstApprovalDate":"","aiSummary":"CQ (chloroquine) and PQ (primaquine) work together as antimalarial agents that disrupt parasite metabolism and eliminate both blood and tissue stages of Plasmodium infection. Used for Malaria (mixed species or P. vivax/P. ovale with relapse prevention), Uncomplicated malaria treatment and radical cure.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}