{"id":"cox-2-inhibitor","safety":{"commonSideEffects":[{"rate":null,"effect":"Cardiovascular events (myocardial infarction, stroke)"},{"rate":null,"effect":"Gastrointestinal ulceration"},{"rate":null,"effect":"Hypertension"},{"rate":null,"effect":"Edema"},{"rate":null,"effect":"Dyspepsia"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"COX-2 is an inducible enzyme upregulated during inflammation and produces prostaglandins that drive pain, fever, and inflammatory responses. By selectively inhibiting COX-2 while sparing COX-1, these drugs reduce inflammatory prostaglandins while theoretically preserving the protective prostaglandins in the gastrointestinal tract. 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