{"id":"counseling-otp","safety":{"commonSideEffects":[{"rate":null,"effect":"Withdrawal symptoms (if inadequately dosed)"},{"rate":null,"effect":"Constipation"},{"rate":null,"effect":"Sedation"},{"rate":null,"effect":"Nausea"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This is a combined psychosocial and pharmacological intervention for opioid use disorder. Counseling addresses behavioral, psychological, and social factors driving opioid dependence, while OTP (typically involving methadone or buprenorphine) reduces cravings and withdrawal symptoms. Together, they aim to improve treatment retention and long-term abstinence or controlled use outcomes.","oneSentence":"Counseling combined with opioid treatment program (OTP) provides behavioral therapy and medication-assisted treatment to reduce opioid use and support recovery.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:45:28.205Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Opioid use disorder"}]},"trialDetails":[{"nctId":"NCT06380504","phase":"NA","title":"Increasing the Coverage of Severe Acute Malnutrition (SAM) Treatment in Ethiopia","status":"RECRUITING","sponsor":"International Food Policy Research Institute","startDate":"2024-05-02","conditions":"Acute Malnutrition, Severe, Malnutrition, Child, Wasting","enrollment":1080},{"nctId":"NCT04308694","phase":"EARLY_PHASE1","title":"Opioid Treatment Program (OTP)-Pharmacy Collaboration for Methadone Maintenance Treatment","status":"COMPLETED","sponsor":"Friends Research Institute, Inc.","startDate":"2020-08-06","conditions":"Opioid-use Disorder","enrollment":20},{"nctId":"NCT00574067","phase":"PHASE3","title":"Buprenorphine for Prisoners","status":"COMPLETED","sponsor":"Friends Research Institute, Inc.","startDate":"2008-09","conditions":"Heroin Addiction","enrollment":213},{"nctId":"NCT02460848","phase":"NA","title":"Effects of Cash Transfers on Severe Acute Malnutrition","status":"COMPLETED","sponsor":"UNICEF","startDate":"2015-07","conditions":"Severe Malnutrition","enrollment":1600}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":31,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Suboxone"],"phase":"phase_3","status":"active","brandName":"Counseling +OTP","genericName":"Counseling +OTP","companyName":"Friends Research Institute, Inc.","companyId":"friends-research-institute-inc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Counseling +OTP is an intervention studied in clinical trials for conditions such as heroin addiction and opioid-use disorder. Docusate, a small molecule surfactant laxative, is the active ingredient in OTP.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}