{"id":"coumetarol","rwe":[],"tags":[{"label":"coumetarol","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"dicumoxan","offLabel":[],"synonyms":["coumetarol","cumetharol","cumethoxaethane","dicoumoxyl","dicumoxan","dicumoxane"],"timeline":[],"approvals":[],"brandName":"Dicumoxan","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"coumetarol","explanation":"Think of it like a brake on your car's engine. Vitamin K epoxide reductase helps your body make blood clots, which can be useful in some situations, but also cause problems if they form too easily. Dicumoxan puts the brake on this process, helping to prevent excessive blood clotting.","oneSentence":"Dicumoxan works by inhibiting vitamin K epoxide reductase, which is involved in blood clotting.","technicalDetail":"Dicumoxan specifically inhibits VKOR, a flavoprotein enzyme responsible for the reduction of vitamin K epoxide to vitamin K hydroquinone, which is essential for the gamma-carboxylation of vitamin K-dependent clotting factors."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3721","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=COUMETAROL","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T10:18:49.286702","biosimilars":[],"competitors":[],"genericName":"coumetarol","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"UO1VQB3SPZ","CHEBI":"CHEBI:135591","INN_ID":"1520","UMLSCUI":"C0056425","ChEMBL_ID":"CHEMBL2106007","PUBCHEM_CID":"54716150","MESH_SUPPLEMENTAL_RECORD_UI":"C060966"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":0,"therapeuticAreas":["Hematology"],"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Dicumoxan, also known as Cumetarol, is a small molecule. Its exact mechanism and indications are not specified in the provided information.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}