{"id":"cotadutide-100-micrograms","safety":{"commonSideEffects":[{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Vomiting"},{"rate":null,"effect":"Diarrhea"},{"rate":null,"effect":"Injection site reactions"}]},"_chembl":{"chemblId":"CHEMBL4297630","moleculeType":"Protein","molecularWeight":"3728.09"},"_dailymed":null,"mechanism":{"_ai_source":"anthropic-haiku","explanation":"By simultaneously activating GLP-1 and glucagon receptors, cotadutide enhances insulin secretion, reduces glucagon when appropriate, slows gastric emptying, and increases energy expenditure. This dual mechanism is designed to provide superior glycemic control and weight reduction compared to GLP-1 monotherapy, particularly in patients with type 2 diabetes and obesity.","oneSentence":"Cotadutide is a dual GLP-1/GCG receptor agonist that activates both glucagon-like peptide-1 and glucagon receptors to improve glucose control and promote weight loss.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T03:29:00.062Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Type 2 diabetes mellitus"},{"name":"Obesity or overweight with weight-related comorbidities"}]},"trialDetails":[],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["MEDI0382"],"phase":"phase_2","status":"active","brandName":"Cotadutide 100 micrograms","genericName":"Cotadutide 100 micrograms","companyName":"AstraZeneca","companyId":"astrazeneca","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Cotadutide is a dual GLP-1/GCG receptor agonist that activates both glucagon-like peptide-1 and glucagon receptors to improve glucose control and promote weight loss. Used for Type 2 diabetes mellitus, Obesity or overweight with weight-related comorbidities.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":false,"score":3}}