{"id":"corticosteroids-therapy","safety":{"commonSideEffects":[{"rate":"null","effect":"Gastrointestinal bleeding"},{"rate":"null","effect":"Osteoporosis"},{"rate":"null","effect":"Glaucoma"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"This is achieved through the binding of corticosteroids to glucocorticoid receptors, which then translocate to the nucleus and regulate the expression of genes involved in inflammation. As a result, corticosteroids reduce the production of pro-inflammatory cytokines and increase the production of anti-inflammatory cytokines, leading to a decrease in inflammation and immune response.","oneSentence":"Corticosteroids suppress the immune system by inhibiting the production of inflammatory cytokines.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:07:21.437Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Rheumatoid arthritis"},{"name":"Asthma"},{"name":"Multiple sclerosis"}]},"trialDetails":[{"nctId":"NCT03790293","phase":"PHASE3","title":"Clinical and Immunological Long-term Follow-up of Patients With Pemphigus Included in the \"RITUXIMAB 3\" Trial","status":"COMPLETED","sponsor":"University Hospital, Rouen","startDate":"2018-11-17","conditions":"Autoimmune Diseases","enrollment":80}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":336,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"corticosteroids'therapy","genericName":"corticosteroids'therapy","companyName":"University Hospital, Rouen","companyId":"university-hospital-rouen","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Corticosteroids suppress the immune system by inhibiting the production of inflammatory cytokines. Used for Rheumatoid arthritis, Asthma, Multiple sclerosis.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}