{"id":"corticosteroid-eye-drop","safety":{"commonSideEffects":[{"rate":"null","effect":"Increased intraocular pressure"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"They do this by inhibiting the production of pro-inflammatory cytokines and other mediators of inflammation. This leads to a decrease in the number of inflammatory cells in the eye, which helps to reduce swelling and pain. Corticosteroids can also help to prevent scarring and promote healing in the eye.","oneSentence":"Corticosteroid eye drops reduce inflammation in the eye by suppressing the immune system.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T03:29:04.648Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Treatment of non-infectious uveitis affecting the posterior segment of the eye"}]},"trialDetails":[{"nctId":"NCT07496060","phase":"PHASE4","title":"Loteprednol Etabonate Versus Prednisolone Acetate for Anterior Chamber Granulomas","status":"COMPLETED","sponsor":"Fayoum University","startDate":"2025-08-10","conditions":"Anterior Chamber Granulomatous Uveitis","enrollment":66},{"nctId":"NCT06365853","phase":"PHASE2","title":"A Study of Ocular Toxicity Evaluation and Mitigation During Treatment With Mirvetuximab Soravtansine in Participants With Recurrent Ovarian Cancer With High Folate Receptor-Alpha Expression","status":"RECRUITING","sponsor":"AbbVie","startDate":"2024-07-29","conditions":"Recurrent Ovarian Cancer, Folate Receptor-Alpha Positive","enrollment":100},{"nctId":"NCT06235567","phase":"PHASE1, PHASE2","title":"Dextenza Versus Topical Steroid Eye Drops for Postoperative Management Following Corneal Crosslinking","status":"ENROLLING_BY_INVITATION","sponsor":"Maanasa Indaram, MD","startDate":"2025-04-11","conditions":"Keratoconus","enrollment":20},{"nctId":"NCT05626478","phase":"PHASE4","title":"Assessing eFficacy and Safety of DEXTENZA 0.4 mg inseRt, Following Cataract Surgery","status":"COMPLETED","sponsor":"Nicole Fram M.D.","startDate":"2023-06-01","conditions":"Corneal Edema, Corneal Defect, Anterior Chamber Inflammation","enrollment":50},{"nctId":"NCT04371445","phase":"PHASE4","title":"Dextenza in the Post-op Management of Vitreoretinal Surgeries","status":"RECRUITING","sponsor":"The Cleveland Clinic","startDate":"2020-06-01","conditions":"Vitreoretinal Surgery, Ocular Inflammation, Post-operative Pain","enrollment":30},{"nctId":"NCT06213649","phase":"PHASE3","title":"Parasitic Ulcer Treatment Trial","status":"RECRUITING","sponsor":"Jeremy Keenan, MD, MPH","startDate":"2024-07-01","conditions":"Acanthamoeba Keratitis","enrollment":232},{"nctId":"NCT06271772","phase":"PHASE3","title":"Rose Bengal Electromagnetic Activation With Green Light for Infection Reduction II","status":"ACTIVE_NOT_RECRUITING","sponsor":"University of California, San Francisco","startDate":"2024-07-01","conditions":"Bacterial Keratitis","enrollment":60},{"nctId":"NCT05542381","phase":"NA","title":"The Role of Loteprednol in Reducing Post-Intravitreal Injection Related Pain","status":"COMPLETED","sponsor":"Virginia Polytechnic Institute and State University","startDate":"2022-12-22","conditions":"Age-Related Macular Degeneration","enrollment":64},{"nctId":"NCT04130802","phase":"PHASE2","title":"OCS-01 in Treating Inflammation and Pain in Post-cataract Patients","status":"COMPLETED","sponsor":"Oculis","startDate":"2019-09-27","conditions":"Inflammation Corneal, Pain, Postoperative","enrollment":153},{"nctId":"NCT05023304","phase":"PHASE4","title":"In Clinic Optometrist Insertion of Dextenza Prior to Cataract Surgery","status":"COMPLETED","sponsor":"Vance Thompson Vision","startDate":"2021-08-23","conditions":"Cataract","enrollment":30},{"nctId":"NCT05668455","phase":"PHASE3","title":"Comparison of Topical Treatment for Inflammatory Secretions of the Conjonctiva (Patients With Ocular Prostheses)","status":"RECRUITING","sponsor":"Agnes","startDate":"2023-05-12","conditions":"Ocular Inflammation, Ocular Prostheses","enrollment":30},{"nctId":"NCT04734210","phase":"PHASE2","title":"Research Study To See How Well An Eye Drop (SURF-200) Works, What Side Effects There Are, And To Compare It With Vehicle In Subjects With An Episodic Flare-Up of Dry Eye Disease","status":"COMPLETED","sponsor":"Surface Ophthalmics, Inc.","startDate":"2021-01-07","conditions":"Dry Eye Disease","enrollment":139},{"nctId":"NCT04734197","phase":"PHASE2","title":"A Research Study To See How Well an Eye Drop, SURF-100 (A Mycophenolic Acid/Betamethasone Sodium Phosphate Combination), Works and What Side Effects There Are in Subjects With Dry Eye Disease","status":"COMPLETED","sponsor":"Surface Ophthalmics, Inc.","startDate":"2021-01-11","conditions":"Dry Eye Disease","enrollment":349},{"nctId":"NCT04778397","phase":"PHASE3","title":"Study of Magrolimab in Combination With Azacitidine Versus Physician's Choice of Venetoclax in Combination With Azacitidine or Intensive Chemotherapy in Patients With TP53 Mutant Acute Myeloid Leukemia That Have Not Been Treated","status":"TERMINATED","sponsor":"Gilead Sciences","startDate":"2021-07-01","conditions":"Acute Myeloid Leukemia","enrollment":258},{"nctId":"NCT04097730","phase":"PHASE3","title":"Steroids and Cross-linking for Ulcer Treatment","status":"COMPLETED","sponsor":"Thomas M. Lietman","startDate":"2020-09-24","conditions":"Keratitis Bacterial","enrollment":280},{"nctId":"NCT04324359","phase":"PHASE2","title":"Study to See How Well an Eye Drop, SURF-201, Works and What Side Effects There Are in Cataract Surgery Subjects","status":"COMPLETED","sponsor":"Surface Ophthalmics, Inc.","startDate":"2020-03-03","conditions":"Post-surgical Ocular Inflammation, Post-surgical Ocular Pain","enrollment":91},{"nctId":"NCT04396990","phase":"PHASE4","title":"The RESTORE Study, A Randomized, Controlled, Masked (Reading Center) Prospective Study","status":"COMPLETED","sponsor":"Vance Thompson Vision","startDate":"2020-06-08","conditions":"Refractive Surgery","enrollment":20},{"nctId":"NCT06498440","phase":"PHASE4","title":"Efficacy of NSAID vs. Steroid-NSAID Combo Post-Selective Laser Trabeculoplasty: Phase 4, Single-Center RCT","status":"NOT_YET_RECRUITING","sponsor":"St. Joseph's Healthcare Hamilton","startDate":"2024-09-01","conditions":"Open Angle Glaucoma, Ocular Hypertension, Postoperative Inflammation","enrollment":126},{"nctId":"NCT02120079","phase":"PHASE4","title":"The Utility of IVCM to Assess Cellular Response and Efficacy of Long-term Topical Steroid Treatment in Patients With DED","status":"COMPLETED","sponsor":"Tufts Medical Center","startDate":"2014-02","conditions":"Dry Eye Disease","enrollment":37},{"nctId":"NCT04200651","phase":"PHASE4","title":"Prospective Study on DEXTENZA® Safety And Efficacy Following Concomitant MIGS and Cataract Surgery","status":"TERMINATED","sponsor":"The New York Eye Surgery Center","startDate":"2020-01-13","conditions":"Glaucoma, Cataract","enrollment":25},{"nctId":"NCT04184999","phase":"PHASE4","title":"Effect of Intraoperative Dexamethasone on Post-op Dry Eye","status":"COMPLETED","sponsor":"SR Cornea Consultants","startDate":"2019-08-10","conditions":"Dry Eye Syndromes","enrollment":40},{"nctId":"NCT04521140","phase":"PHASE4","title":"Assessing eFficacy and Safety of DEXTENZA 0.4 mg inseRt, Following Corneal Transplant Surgery","status":"COMPLETED","sponsor":"Nicole Fram M.D.","startDate":"2020-10-16","conditions":"Corneal Edema, Corneal Defect, Corneal Transplant","enrollment":36},{"nctId":"NCT04462523","phase":"PHASE4","title":"DEXTENZA for the Treatment of Postoperative Pain and Inflammation Following Vitreo-retinal Surgery","status":"COMPLETED","sponsor":"Patrick R. Oellers, MD","startDate":"2020-01-03","conditions":"Vitreo-Retinal Surgery","enrollment":40},{"nctId":"NCT03418727","phase":"PHASE2","title":"Dry Eye Disease Study With Brimonidine","status":"COMPLETED","sponsor":"Ocugen","startDate":"2017-09-06","conditions":"Dry Eye","enrollment":84},{"nctId":"NCT04940338","phase":"PHASE4","title":"PCME Prevention in Patients With NPDR","status":"COMPLETED","sponsor":"Klinički Bolnički Centar Zagreb","startDate":"2021-05-01","conditions":"Cystoid Macular Edema Following Cataract Surgery","enrollment":90},{"nctId":"NCT05353101","phase":"PHASE1","title":"Cyclosporine 0.05% Eye Drops for Vernal Keratoconjunctivitis Trial","status":"COMPLETED","sponsor":"Second Affiliated Hospital of Nanchang University","startDate":"2020-07-01","conditions":"Vernal Keratoconjunctivitis, Cyclosporine 0.05% Eye Drops","enrollment":48},{"nctId":"NCT04708821","phase":"PHASE4","title":"DEXTENZA Therapy for Treatment of Allergic Conjunctivitis","status":"COMPLETED","sponsor":"Clinical Research Center of Florida","startDate":"2021-04-30","conditions":"Bilateral Conjunctivitis (Disorder)","enrollment":31},{"nctId":"NCT04107246","phase":"","title":"Data Collection of Therapeutic Compliance in Patients Receiving Corneal Graft Using a Collection Box for Corticosteroid Eye Drops","status":"COMPLETED","sponsor":"Centre Hospitalier Universitaire de Saint Etienne","startDate":"2019-11-20","conditions":"Corneal Graft Disorder (Disorder), Corticosteroid","enrollment":30},{"nctId":"NCT05218317","phase":"","title":"Evaluation of Relapse Presence in Multiple Sclerosis","status":"COMPLETED","sponsor":"Marmara University","startDate":"2021-01-01","conditions":"Multiple Sclerosis, Relapsing-Remitting, Multiple Sclerosis Relapse","enrollment":87},{"nctId":"NCT03626376","phase":"PHASE4","title":"Topical Corticosteroid Use in Addition to Oral Antivirals for Prevention of Recurrence of Herpes Simplex Virus (HSV) Keratitis","status":"WITHDRAWN","sponsor":"NYU Langone Health","startDate":"2019-12-10","conditions":"Herpes Simplex Virus Keratitis","enrollment":""},{"nctId":"NCT04871256","phase":"NA","title":"Effects of Septorhinoplasty on Allergic Rhinitis","status":"COMPLETED","sponsor":"Mario Pérez Sayáns","startDate":"2021-01-01","conditions":"Allergic Rhinitis","enrollment":51},{"nctId":"NCT04597762","phase":"NA","title":"Effect of Ciclosporin Eyedrops on Sjögren Syndrome","status":"COMPLETED","sponsor":"Hospital Hietzing","startDate":"2020-08-31","conditions":"Dry Eye Syndromes","enrollment":12},{"nctId":"NCT03248037","phase":"PHASE3","title":"Trial of Netarsudil for Prevention of Corticosteroid-induced Intraocular Pressure Elevation","status":"COMPLETED","sponsor":"Cornea Research Foundation of America","startDate":"2017-09-05","conditions":"Fuchs' Endothelial Dystrophy, Bullous Keratopathy","enrollment":120},{"nctId":"NCT01939691","phase":"PHASE4","title":"Macular Edema Nepafenac vs. Difluprednate Uveitis Trial","status":"TERMINATED","sponsor":"University of California, San Francisco","startDate":"2018-09-12","conditions":"Uveitis, Macular Edema","enrollment":9},{"nctId":"NCT02218489","phase":"PHASE2","title":"Safety and Efficacy of KPI-121 in Subjects With Inflammatory Meibomian Gland Disease","status":"COMPLETED","sponsor":"Kala Pharmaceuticals, Inc.","startDate":"2014-07","conditions":"Blepharitis","enrollment":206},{"nctId":"NCT02717871","phase":"PHASE3","title":"Swiss PACK-CXL Multicenter Trial for the Treatment of Infectious Keratitis","status":"COMPLETED","sponsor":"University Hospital, Geneva","startDate":"2016-03","conditions":"Keratitis; Infectious Disease (Manifestation)","enrollment":35},{"nctId":"NCT04426734","phase":"PHASE4","title":"Evaluation of DEXTENZA in the Management of Pain and Inflammation in Patients With Anterior Uveitis Compared to Standard of Care Topical Corticosteroids","status":"UNKNOWN","sponsor":"New England Retina Associates","startDate":"2020-07-01","conditions":"Non-infectious Anterior Uveitis","enrollment":30},{"nctId":"NCT04376970","phase":"PHASE4","title":"Treatment of Corneal Infiltrates Secondary to Epidemic Keratoconjunctivitis","status":"COMPLETED","sponsor":"Military Hospital of Tunis","startDate":"2017-04-01","conditions":"Adenoviral Keratoconjunctivitis","enrollment":51},{"nctId":"NCT04281862","phase":"PHASE4","title":"DEXTENZA Compared to Topical Prednisolone in Patients Undergoing Bilateral LASIK Surgery","status":"UNKNOWN","sponsor":"Vance Thompson Vision","startDate":"2020-01-23","conditions":"Refractive Surgery","enrollment":20},{"nctId":"NCT01797822","phase":"PHASE4","title":"Effects of Dry Eye Treatments on the Ocular Surface","status":"COMPLETED","sponsor":"Baylor College of Medicine","startDate":"2013-02","conditions":"Keratoconjunctivitis Sicca, Dry Eye Syndrome","enrollment":20},{"nctId":"NCT03693989","phase":"PHASE3","title":"Clinical Study of the Efficacy of the Ophthalmic Emulsion PRO-145 for Inflammation and Pain After Phacoemulsification","status":"COMPLETED","sponsor":"Laboratorios Sophia S.A de C.V.","startDate":"2018-10-04","conditions":"Cataract","enrollment":178},{"nctId":"NCT04117698","phase":"PHASE3","title":"Multicenter, Randomized Study Evaluating the Value of Antitubercular Treatment During Recurent Anterior Uveitis (URBA)","status":"UNKNOWN","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2019-11-01","conditions":"Uveitis, Anterior","enrollment":116},{"nctId":"NCT01443442","phase":"PHASE4","title":"Bepreve vs. Alrex in Subjects With Moderate to Severe Allergic Conjunctivitis","status":"COMPLETED","sponsor":"Southern California College of Optometry at Marshall B. Ketchum University","startDate":"2011-10","conditions":"Allergic Conjunctivitis","enrollment":23},{"nctId":"NCT03970148","phase":"NA","title":"YAG Laser Vitreolysis for Floaters","status":"UNKNOWN","sponsor":"University Hospital of Split","startDate":"2019-04-02","conditions":"Vitreous Detachment","enrollment":100},{"nctId":"NCT01843920","phase":"NA","title":"The Effect of Glaucoma Drops on of the Duration of a Pure Intraocular Gas Bubble","status":"COMPLETED","sponsor":"Jason Hsu, MD","startDate":"2011-06","conditions":"Scleral Buckling","enrollment":21},{"nctId":"NCT02007174","phase":"","title":"Bevacizumab Injection for Recurrent Pterygium","status":"COMPLETED","sponsor":"Instituto de Oftalmología Fundación Conde de Valenciana","startDate":"2012-03","conditions":"Recurrent Pterygium","enrollment":38},{"nctId":"NCT01456780","phase":"PHASE4","title":"Efficacy of Zylet vs. Lotemax for the Treatment of Ocular Surface Inflammation/MGD/Blepharitis","status":"COMPLETED","sponsor":"Massachusetts Eye and Ear Infirmary","startDate":"2011-08","conditions":"Meibomian Gland Dysfunction, Posterior Blepharitis","enrollment":60},{"nctId":"NCT01058278","phase":"NA","title":"Impact Post-operative Treatment on Intraocular Pressure Post-SLT on Patients With Primary Open-angle Glaucoma","status":"COMPLETED","sponsor":"CHU de Quebec-Universite Laval","startDate":"2008-03","conditions":"Glaucoma, Inflammatory Response","enrollment":67},{"nctId":"NCT01853696","phase":"PHASE4","title":"Comparison of Corticosteroid Dosing Regimens After Endothelial Keratoplasty","status":"COMPLETED","sponsor":"Cornea Research Foundation of America","startDate":"2013-03","conditions":"Fuchs' Dystrophy, Corneal Edema","enrollment":167},{"nctId":"NCT01448213","phase":"PHASE2","title":"Comparison of Two Steroid Regimens to Prevent Transplant Rejection After Corneal Transplant (DMEK)","status":"COMPLETED","sponsor":"Price Vision Group","startDate":"2011-10","conditions":"Fuchs' Dystrophy, Bullous Keratopathy","enrollment":264},{"nctId":"NCT02011776","phase":"","title":"A Randomized, Parallel-Group Comparison Study of Topical Corticosteroids in Dry Eye Patients With Sjögren Syndrome","status":"COMPLETED","sponsor":"Santen Pharmaceutical(China) Co.,LTD","startDate":"2013-03","conditions":"Dry Eye Syndromes, Sjögren Syndrome","enrollment":35},{"nctId":"NCT01562795","phase":"NA","title":"Efficacy of Nonsteroidal Anti-inflammatory Drugs in Treatment of Moderate and Severe Dry Eye Disease","status":"COMPLETED","sponsor":"Wenzhou Medical University","startDate":"2012-03","conditions":"Moderate to Severe Dry Eye Syndrome","enrollment":48},{"nctId":"NCT00494494","phase":"PHASE4","title":"Effect of Nepafenac on Post-operative Macular Swelling Following Uncomplicated Cataract Surgery","status":"COMPLETED","sponsor":"University of North Carolina, Chapel Hill","startDate":"2007-06","conditions":"Cystoid Macular Edema","enrollment":82},{"nctId":"NCT00800423","phase":"PHASE3","title":"Effect of Topical Brimonidine on Post Cataract Surgery Corneal Edema","status":"UNKNOWN","sponsor":"Rabin Medical Center","startDate":"2009-01","conditions":"Corneal Edema, Visual Acuity","enrollment":150}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":11,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_2","status":"active","brandName":"Corticosteroid Eye Drop","genericName":"Corticosteroid Eye Drop","companyName":"Ocugen","companyId":"ocugen","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Corticosteroid eye drops are used to treat conditions such as uveitis, anterior uveitis, and possibly other eye conditions including glaucoma, cataract, and vitreous detachment. The exact mechanism of corticosteroid eye drops is not specified in the provided facts, but they are likely anti-inflammatory agents, as indicated by ChEMBL.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}